Reactome | FFAR3 [plasma membrane]

FFAR3 [plasma membrane]

Stable Identifier

R-HSA-443951

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Free fatty acid receptor 3, FFAR3_HUMAN, GPR41

Locations in the PathwayBrowser for interactor UniProt:Q9Y2W7 KCNIP3

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External Reference Information

External Reference

UniProt:O14843 FFAR3

Gene Names

FFAR3, GPR41

Chain

chain:1-346

Reference Genes

BioGPS Gene:2865 FFAR3

COSMIC (genes):FFAR3 FFAR3

CTD Gene:2865 FFAR3

dbSNP Gene:2865 FFAR3

ENSEMBL:ENSG00000185897 FFAR3

HGNC:4499 FFAR3

KEGG:hsa:2865 FFAR3

Monarch:2865 FFAR3

NCBI Gene:2865 FFAR3

OMIM:603821 FFAR3

UCSC:O14843 FFAR3

Reference Transcript

RefSeq:NM_005304.4 FFAR3

Other Identifiers

11740236_at

16861012

221385_PM_s_at

221385_s_at

2865

3830421

3830422

3830423

3830424

3830425

3830431

3830432

8027856

8027860

A_33_P3298810

GE61014

GO:0002376

GO:0002385

GO:0002720

GO:0002879

GO:0004930

GO:0005515

GO:0005886

GO:0006954

GO:0007186

GO:0007193

GO:0008289

GO:0014061

GO:0016020

GO:0032722

GO:0045776

GO:0046626

GO:0046885

GO:0060089

GO:0071398

GO:0090276

HMNXSV003001570

ILMN_1671276

PH_hs_0027507

TC19000467.hg

TC19000468.hg

g4885330_3p_s_at

Participates

as an input of

Receptor FFAR3 binds carboxylates (Homo sapiens)

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)

as a component of

FFAR3:FFAR3 ligands [plasma membrane] (Homo sapiens)

Inferred To

si:dkey-211g8.7 [plasma membrane] (Danio rerio)

Ffar3 [plasma membrane] (Mus musculus)

Ffar3 [plasma membrane] (Rattus norvegicus)

FFAR3 [plasma membrane] (Canis familiaris)

GPR41 [plasma membrane] (Bos taurus)

FFAR1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_005295.1

Guide to Pharmacology - Targets

227

ENSEMBL

ENST00000327809, ENSP00000469522, ENSP00000328230, ENST00000594310

OpenTargets

ENSG00000185897

HPA

ENSG00000185897-FFAR3

ZINC - Substances

FFAR3_HUMAN

ZINC target

O14843

PRO

O14843

Pharos - Targets

O14843

GlyGen

O14843

HMDB Protein

HMDBP02025

PDB

8J20, 8J21

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6I9 TEX264	2	TEX264 [platelet alpha granule lumen] (R-HSA-8863000) TEX264 [extracellular region] (R-HSA-8863002)	0.556	3
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:P52803 EFNA5	3	EFNA5 (21-?) N-ter [extracellular region] (R-HSA-3928456) EFNA5 (?-203) C-ter [plasma membrane] (R-HSA-3928431) EFNA5 [plasma membrane] (R-HSA-2682331)	0.556	3
UniProt:Q4LDR2 CTXN3			0.556	3
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 P345Pfs103 [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 L230Afs188 [endoplasmic reticulum membrane] (R-HSA-9628869)	0.556	3
UniProt:Q96B49 TOMM6	1	TOMM6 [mitochondrial outer membrane] (R-HSA-1252171)	0.556	3
UniProt:Q9NSU2-1 TREX1			0.556	3
UniProt:O43561-2 LAT	2	p-5Y-LAT-2 [plasma membrane] (R-HSA-2396597) LAT-2 [plasma membrane] (R-HSA-2396548)	0.556	3
UniProt:Q9NRX5 SERINC1	1	SERINC1 [plasma membrane] (R-HSA-5215963)	0.556	3
UniProt:Q9Y548 YIPF1			0.556	3
UniProt:Q9Y2W7 KCNIP3	2	KCNIP3 [plasma membrane] (R-HSA-5577044) KCNIP3 [nucleoplasm] (R-HSA-9640052)	0.556	3
UniProt:P21964 COMT	2	COMT [cytosol] (R-HSA-175974) COMT [plasma membrane] (R-HSA-379386)	0.556	3
UniProt:Q8IVJ1 SLC41A1	1	SLC41A1 [plasma membrane] (R-HSA-442659)	0.556	3
UniProt:Q16873 LTC4S	2	LTC4S [endoplasmic reticulum membrane] (R-HSA-2142692) LTC4S [nuclear envelope] (R-HSA-266025)	0.556	3

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