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FZD4 [plasma membrane]
Stable Identifier
R-HSA-443956
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Frizzled-4, FZD4_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P01023 A2M
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
WNT5A-dependent internalization of FZD4 (Homo sapiens)
WNT5A binds FZD4 (Homo sapiens)
FZD4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9ULV1 FZD4
Gene Names
FZD4
Chain
signal peptide:1-36, chain:37-537
Reference Genes
BioGPS Gene:8322 FZD4
COSMIC (genes):FZD4 FZD4
CTD Gene:8322 FZD4
dbSNP Gene:8322 FZD4
ENSEMBL:ENSG00000174804 FZD4
ENSEMBL_homo_sapiens_GENE:ENSG00000174804.4 FZD4
HGNC:4042 FZD4
KEGG Gene (Homo sapiens):8322 FZD4
Monarch:8322 FZD4
NCBI Gene:8322 FZD4
OMIM:604579 FZD4
UCSC:Q9ULV1 FZD4
Reference Transcript
RefSeq:NM_012193.3 FZD4
Other Identifiers
11719012_at
11719013_at
11719014_s_at
16743091
218665_PM_at
218665_at
224337_PM_s_at
224337_s_at
3385511
3385512
3385513
3385514
3385515
3385516
3385517
3385518
3385519
3385520
3385521
3385522
3385523
3385524
3385525
3385526
3385531
3385532
3385533
3385534
46040_at
56244_at
62872_at
74449_at
7950885
82797_at
8322
A_23_P64617
A_24_P278621
GE58470
GO:0001525
GO:0001540
GO:0001553
GO:0001568
GO:0001570
GO:0001666
GO:0004888
GO:0004896
GO:0004930
GO:0005515
GO:0005886
GO:0005911
GO:0006351
GO:0006355
GO:0007155
GO:0007165
GO:0007166
GO:0007186
GO:0007223
GO:0007605
GO:0008283
GO:0009986
GO:0010812
GO:0016020
GO:0016055
GO:0017147
GO:0019221
GO:0019955
GO:0022414
GO:0023052
GO:0030154
GO:0030165
GO:0030182
GO:0030335
GO:0030425
GO:0030669
GO:0030947
GO:0031410
GO:0031625
GO:0031987
GO:0034446
GO:0035426
GO:0035567
GO:0038023
GO:0042701
GO:0042803
GO:0042813
GO:0043226
GO:0044877
GO:0045202
GO:0045446
GO:0045893
GO:0046982
GO:0048856
GO:0048870
GO:0050775
GO:0050877
GO:0050886
GO:0051091
GO:0060070
GO:0060089
GO:0060856
GO:0061298
GO:0061299
GO:0061301
GO:0061304
GO:0071300
GO:0098978
GO:0110135
GO:0150012
GO:1990830
HMNXSV003042101
ILMN_1743367
PH_hs_0001716
TC11002170.hg
g13548680_3p_s_at
g6912383_3p_at
Participates
as a member of
Frizzled receptors [plasma membrane] (Homo sapiens)
FZD [plasma membrane] (Homo sapiens)
WNT/Ca2+ FZDs [plasma membrane] (Homo sapiens)
as an input of
WNT5A binds FZD4 (Homo sapiens)
as a component of
N4GlycoAsn-PalmS-WNT5A:FZD4 [plasma membrane] (Homo sapiens)
as a candidate of
WNT5A-binding FZDs [plasma membrane] (Homo sapiens)
Other forms of this molecule
ub-FZD4 [plasma membrane]
FZD4 [clathrin-coated endocytic vesicle membrane]
Inferred To
Fzd4 [plasma membrane]
(Mus musculus)
Fzd4 [plasma membrane]
(Rattus norvegicus)
FZD4 [plasma membrane]
(Bos taurus)
FZD4 [plasma membrane]
(Canis familiaris)
FZD4 [plasma membrane]
(Gallus gallus)
FZD4 [plasma membrane]
(Sus scrofa)
fzd4 [plasma membrane]
(Xenopus tropicalis)
lin-17 [plasma membrane]
(Caenorhabditis elegans)
Ghost homologue of FZD4 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_036325.2
Guide to Pharmacology - Targets
232
OpenTargets
ENSG00000174804
HPA
ENSG00000174804-FZD4
GeneCards
Q9ULV1
Ensembl
ENSG00000174804
,
ENST00000531380
,
ENSP00000434034
PRO
Q9ULV1
Pharos - Targets
Q9ULV1
Orphanet
16085
HMDB Protein
HMDBP07700
PDB
5UWG
,
6BD4
,
5CL1
,
5BQE
,
5BQC
,
5CM4
,
5BPB
,
6NE1
,
5BPQ
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:P01023 A2M
2
A2M [extracellular region]
(R-HSA-49291)
A2M [platelet alpha granule lumen]
(R-HSA-139834)
0.556
3
UniProt:P50570-2 DNM2
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:Q00604 NDP
0.528
4
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