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CCL4(24-92) [extracellular region]
Stable Identifier
R-HSA-443976
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
CCL4, C-C motif chemokine 4, CCL4_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptor ACKR2 binds most inflammatory CC chemokines (Homo sapiens)
ACKR2:CCBP2 ligands [plasma membrane] (Homo sapiens)
CCBP2 ligands [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
CCBP2 ligands [extracellular region] (Homo sapiens)
CCL4(24-92) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13236 CCL4
Gene Names
CCL4, LAG1, MIP1B, SCYA4
Chain
signal peptide:1-23, chain:24-92, chain:26-92
Reference Genes
BioGPS Gene:388372 CCL4
BioGPS Gene:6351 CCL4
CTD Gene:388372 CCL4
CTD Gene:6351 CCL4
dbSNP Gene:388372 CCL4
dbSNP Gene:6351 CCL4
ENSEMBL:ENSG00000275302 CCL4
HGNC:10630 CCL4
KEGG:hsa:388372 CCL4
KEGG:hsa:6351 CCL4
Monarch:388372 CCL4
Monarch:6351 CCL4
NCBI Gene:388372 CCL4
NCBI Gene:6351 CCL4
OMIM:182284 CCL4
UCSC:P13236 CCL4
Reference Transcript
RefSeq:NM_207007.3 CCL4
RefSeq:NM_002984.3 CCL4
Other Identifiers
11718982_s_at
11718983_x_at
11746954_s_at
16833420
16833426
16833433
204103_PM_at
204103_at
36674_at
3718931
3718932
3718933
3718934
3718935
3718936
3718937
3718938
3718979
3718980
3718981
3718982
3718983
3718984
3718985
3718986
3719025
3719026
3719027
3719028
3719030
3719031
4040064
4040065
4040066
4040067
4040070
4040071
6351
8006602
8006608
8006621
8019651
A_14_P133531
A_23_P207564
A_33_P3354607
GE57501
GO:0002376
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0006935
GO:0006954
GO:0006955
GO:0007155
GO:0007163
GO:0007165
GO:0007267
GO:0008009
GO:0009615
GO:0009636
GO:0023052
GO:0030335
GO:0031726
GO:0031730
GO:0042802
GO:0043922
GO:0048018
GO:0048020
GO:0048245
GO:0048870
GO:0050850
GO:0051928
GO:0061844
GO:0070098
GO:0098542
GO:0098772
GO:2000503
HMNXSV003012806
ILMN_1716276
J04130_s_at
M69203_s_at
PH_hs_0028969
PH_hs_0039822
TC17000408.hg
g4506844_3p_at
Participates
as a member of
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
CCBP2 ligands [extracellular region] (Homo sapiens)
CCL4, (CCL4L1) [extracellular region] (Homo sapiens)
Inferred To
CCL4(24-92) [extracellular region]
(Gallus gallus)
CCL4 [extracellular region]
(Bos taurus)
CCL4 [extracellular region]
(Canis familiaris)
CCL4 [extracellular region]
(Sus scrofa)
Ccl4 [extracellular region]
(Mus musculus)
Ccl4 [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_002975.1
,
NP_996890.1
ENSEMBL
ENST00000617322
,
ENSP00000478708
,
ENST00000621600
,
ENST00000615863
,
ENSP00000480345
,
ENSP00000482259
OpenTargets
ENSG00000275302
HPA
ENSG00000275302-CCL4
PRO
P13236
Pharos - Targets
P13236
PDB
1HUN
,
1HUM
,
2FFK
,
2X6L
,
1JE4
,
2FIN
,
4RAL
,
3TN2
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BRI3 SLC30A2
2
SLC30A2 [endosome membrane]
(R-HSA-435363)
SLC30A2 [synaptic vesicle membrane]
(R-HSA-4084714)
0.781
8
UniProt:Q9NPL8 TIMMDC1
1
TIMMDC1 [mitochondrial inner membrane]
(R-HSA-5689720)
0.556
3
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.556
3
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.556
3
UniProt:Q3KNW5 SLC10A6
1
SLC10A6 [plasma membrane]
(R-HSA-433091)
0.556
3
UniProt:Q8IWU4 SLC30A8
2
SLC30A8 [Golgi membrane]
(R-HSA-9817561)
SLC30A8 [secretory granule membrane]
(R-HSA-437106)
0.556
3
UniProt:Q6IN84 MRM1
1
MRM1 [mitochondrial matrix]
(R-HSA-6793088)
0.556
3
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
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