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MLN(26-47) [extracellular region]
Stable Identifier
R-HSA-444169
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Motilin, MLN, Promotilin component recommendedName: Motilin /component component recommendedName: Motilin-associated peptide, MOTI_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MLNR:MLN(24-47) [plasma membrane] (Homo sapiens)
MLN(26-47) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MLNR:MLN(24-47) [plasma membrane] (Homo sapiens)
MLN(26-47) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MLNR:MLN(24-47) [plasma membrane] (Homo sapiens)
MLN(26-47) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MLNR:MLN(24-47) [plasma membrane] (Homo sapiens)
MLN(26-47) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
MLNR:MLN(24-47) [plasma membrane] (Homo sapiens)
MLN(26-47) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
MLN(26-47) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
MLNR (GPR38) is a receptor for motilin (Homo sapiens)
MLN(26-47) [extracellular region] (Homo sapiens)
MLNR:MLN(24-47) [plasma membrane] (Homo sapiens)
MLN(26-47) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P12872 MLN
Gene Names
MLN
Chain
signal peptide:1-25, chain:26-115, peptide:26-47, peptide:50-115
Reference Genes
BioGPS Gene:4295 MLN
COSMIC (genes):MLN MLN
CTD Gene:4295 MLN
dbSNP Gene:4295 MLN
ENSEMBL:ENSG00000096395 MLN
ENSEMBL_homo_sapiens_GENE:ENSG00000096395.11 MLN
HGNC:7141 MLN
KEGG Gene (Homo sapiens):4295 MLN
Monarch:4295 MLN
NCBI Gene:4295 MLN
OMIM:158270 MLN
UCSC:P12872 MLN
Reference Transcript
RefSeq:NM_001184698.1 MLN
RefSeq:NM_001040109.1 MLN
RefSeq:NM_002418.2 MLN
Other Identifiers
11753741_a_at
17018329
207473_PM_at
207473_at
2950888
2950889
2950892
2950894
2950895
2950896
33480_at
4295
8125798
A_23_P19523
A_23_P19529
GE81152
GO:0005179
GO:0005515
GO:0005576
GO:0007165
GO:0023052
GO:0031788
GO:0048018
GO:0098772
HMNXSV003021258
ILMN_1685858
ILMN_2394147
TC06001594.hg
X15393_rna1_at
g4557033_3p_at
Participates
as an input of
MLNR (GPR38) is a receptor for motilin (Homo sapiens)
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
as a component of
MLNR:MLN(24-47) [plasma membrane] (Homo sapiens)
Inferred To
mln [extracellular region]
(Bos taurus)
MLN [extracellular region]
(Canis familiaris)
MLN [extracellular region]
(Sus scrofa)
MLN(26-47) [extracellular region]
(Gallus gallus)
Cross References
RefSeq
NP_002409.1
,
NP_001171627.1
,
NP_001035198.1
OpenTargets
ENSG00000096395
HPA
ENSG00000096395-MLN
GeneCards
P12872
Ensembl
ENST00000266003
,
ENSP00000388825
,
ENSP00000266003
,
ENST00000507738
,
ENSP00000425467
,
ENSG00000096395
,
ENST00000430124
PRO
P12872
Pharos - Targets
P12872
PDB
1LBJ
,
8IBV
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y320 TMX2
0.556
3
UniProt:Q6DKK2 TTC19
1
TTC19 [mitochondrial inner membrane]
(R-HSA-9906047)
0.556
3
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