Free fatty acid receptors

Stable Identifier
R-HSA-444209
Type
Pathway
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Fatty acids are the ligands for a small family of G-protein-coupled receptors, the Free Fatty Acid receptors, and an unrelated receptor GPR120.

Free fatty acid receptor 1 (FFAR1/GPR40) is activated by both saturated and unsaturated medium to long-chain fatty acids while FFAR2 (GPR43) and FFAR3 (GPR41) are activated by short-chain fatty acids (carboxylates) with six or fewer carbon molecules. A fourth highly homologous receptor GPR42 is believed to be a pseudogene with intact open reading frame, but could be a functional gene in a significant fraction of the human population.

GPR120 is activated by long chain (C16-22) fatty acids.
Literature References
PubMed ID Title Journal Year
15684720 A family of fatty acid binding receptors

Briscoe, CP, Jupe, S, Brown, AJ

DNA Cell Biol 2005
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