Reactome | TRHR [plasma membrane]

TRHR [plasma membrane]

Stable Identifier

R-HSA-444556

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Thyrotropin-releasing hormone receptor, TRFR_HUMAN, TRH-R

Locations in the PathwayBrowser for interactor UniProt:I3L0A0 I3L0A0

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External Reference Information

External Reference

UniProt:P34981 TRHR

Gene Names

TRHR

Chain

chain:1-398

Reference Genes

BioGPS Gene:7201 TRHR

COSMIC (genes):TRHR TRHR

CTD Gene:7201 TRHR

dbSNP Gene:7201 TRHR

ENSEMBL:ENSG00000174417 TRHR

HGNC:12299 TRHR

KEGG:hsa:7201 TRHR

Monarch:7201 TRHR

NCBI Gene:7201 TRHR

OMIM:188545 TRHR

UCSC:P34981 TRHR

Reference Transcript

Other Identifiers

11740600_at

17071846

211438_PM_at

211438_at

3111489

3111490

3111491

3111494

3111495

3111496

7201

750_at

8147877

A_23_P322008

D85376_at

GE532953

GO:0004930

GO:0004997

GO:0005515

GO:0005886

GO:0007186

GO:0007200

GO:0016020

GO:0060089

HMNXSV003056219

ILMN_1719393

ILMN_2062832

PH_hs_0000381

TC08000665.hg

g577631_3p_at

Participates

as an input of

Thyrotropin-releasing hormone receptor binds thyrotropin (Homo sapiens)

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)

as a component of

TRH:TRHR [plasma membrane] (Homo sapiens)

Inferred To

Trhr [plasma membrane] (Mus musculus)

Trhr [plasma membrane] (Rattus norvegicus)

TRHR [plasma membrane] (Bos taurus)

TRHR [plasma membrane] (Canis familiaris)

TRHR [plasma membrane] (Gallus gallus)

TRHR [plasma membrane] (Sus scrofa)

trhr-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_011515565.1, NP_003292.1

ZINC - World Drugs

TRFR_HUMAN

Guide to Pharmacology - Targets

363

OpenTargets

ENSG00000174417

ENSEMBL

ENST00000311762, ENSP00000430711, ENSP00000309818, ENST00000518632

ZINC - Substances

TRFR_HUMAN

ZINC target

P34981

PRO

P34981

GlyGen

P34981

PDB

7WKD, 7X1U, 7X1T, 7XW9

HPA

ENSG00000174417-TRHR

Pharos - Targets

P34981

Orphanet

TRHR

ZINC - Predictions - Purchasable

TRFR_HUMAN

HMDB Protein

HMDBP08073

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11117 PPAL			0.564	2
UniProt:P29033 GJB2	3	GJB2 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190614) GJB2 [endoplasmic reticulum membrane] (R-HSA-1629779) GJB2 [plasma membrane] (R-HSA-53211)	0.556	3
UniProt:P21964 COMT	2	COMT [cytosol] (R-HSA-175974) COMT [plasma membrane] (R-HSA-379386)	0.556	3
UniProt:Q9Y385 UBE2J1	1	UBE2J1 [cytosol] (R-HSA-947625)	0.556	3
UniProt:I3L0A0 I3L0A0			0.556	3
UniProt:Q8IVJ1 SLC41A1	1	SLC41A1 [plasma membrane] (R-HSA-442659)	0.556	3
UniProt:Q9Y5U9 IR3IP			0.556	3
UniProt:A2RU14 TM218			0.556	3
UniProt:Q9UIK5 TEFF2			0.556	3
UniProt:Q8WW34-2 TMEM239			0.556	3
UniProt:Q9NP94 SLC39A2	1	SLC39A2 [plasma membrane] (R-HSA-442395)	0.556	3
UniProt:Q86Z23 C1QL4			0.556	3
IntAct:EBI-23343277 CCSB ORF ID			0.556	3
UniProt:P52803 EFNA5	3	EFNA5 (21-?) N-ter [extracellular region] (R-HSA-3928456) EFNA5 (?-203) C-ter [plasma membrane] (R-HSA-3928431) EFNA5 [plasma membrane] (R-HSA-2682331)	0.556	3
UniProt:Q96D05-2 FAM241B			0.556	3
UniProt:Q96EC8 YIPF6	2	YIPF6 [Golgi membrane] (R-HSA-434346) YIPF6 [cytoplasmic vesicle membrane] (R-HSA-434199)	0.556	3
UniProt:Q0D2K0 NIPAL4	1	NIPAL4 [plasma membrane] (R-HSA-5216046)	0.556	3
UniProt:Q9NUM3 S39A9			0.556	3

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