Reactome | PROK1 [extracellular region]

PROK1 [extracellular region]

Stable Identifier

R-HSA-444616

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Prokineticin-1, PROK1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK1 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK1 [extracellular region] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK1 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK1 [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK1 [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK1 [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Prokineticin receptors bind prokineticin (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK1 [extracellular region] (Homo sapiens)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P58294 PROK1

Gene Names

PROK1, UNQ600/PRO1186

Chain

signal peptide:1-19, chain:20-105

Reference Genes

BioGPS Gene:84432 PROK1

COSMIC (genes):PROK1 PROK1

CTD Gene:84432 PROK1

dbSNP Gene:84432 PROK1

ENSEMBL:ENSG00000143125 PROK1

HGNC:18454 PROK1

KEGG:hsa:84432 PROK1

Monarch:84432 PROK1

NCBI Gene:84432 PROK1

OMIM:606233 PROK1

UCSC:P58294 PROK1

Reference Transcript

RefSeq:NM_032414.2 PROK1

Other Identifiers

11727288_at

16668564

229124_PM_at

229124_at

2351466

2351467

2351468

2351470

2351471

2351472

2351473

2351474

7903884

84432

90348_at

A_23_P51745

GE62826

GO:0001525

GO:0001935

GO:0005576

GO:0007165

GO:0008083

GO:0008283

GO:0043410

GO:0045765

GO:0048018

GO:0051781

GO:0098772

GO:0101023

GO:1905564

HMNXSV003040738

Hs.14060.0.A1_3p_at

ILMN_1716259

PH_hs_0001345

TC01000966.hg

Participates

as a member of

PROK1,PROK2 [extracellular region] (Homo sapiens)

Inferred To

PROK1 [extracellular region] (Bos taurus)

PROK1 [extracellular region] (Canis familiaris)

PROK1 [extracellular region] (Gallus gallus)

PROK1 [extracellular region] (Sus scrofa)

prok1 [extracellular region] (Danio rerio)

Prok1 [extracellular region] (Mus musculus)

Prok1 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_115790.1

ENSEMBL

ENST00000271331, ENSP00000271331

OpenTargets

ENSG00000143125

HPA

ENSG00000143125-PROK1

PRO

P58294

Pharos - Targets

P58294