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PROKR2 [plasma membrane]
Stable Identifier
R-HSA-444637
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Prokineticin receptor 2, PKR2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
PROKR1,PROKR2 [plasma membrane] (Homo sapiens)
PROKR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
PROKR1,PROKR2 [plasma membrane] (Homo sapiens)
PROKR2 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
PROKR1,PROKR2 [plasma membrane] (Homo sapiens)
PROKR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
PROKR1,PROKR2 [plasma membrane] (Homo sapiens)
PROKR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
PROKR1,PROKR2 [plasma membrane] (Homo sapiens)
PROKR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
PROKR1,PROKR2 [plasma membrane] (Homo sapiens)
PROKR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Prokineticin receptors bind prokineticin (Homo sapiens)
PROKR1,PROKR2 [plasma membrane] (Homo sapiens)
PROKR2 [plasma membrane] (Homo sapiens)
PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
PROKR1,PROKR2 [plasma membrane] (Homo sapiens)
PROKR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NFJ6 PROKR2
Gene Names
PROKR2, GPR73L1, PKR2
Chain
chain:1-384
Reference Genes
BioGPS Gene:128674 PROKR2
COSMIC (genes):PROKR2 PROKR2
CTD Gene:128674 PROKR2
dbSNP Gene:128674 PROKR2
ENSEMBL:ENSG00000101292 PROKR2
HGNC:15836 PROKR2
KEGG:hsa:128674 PROKR2
Monarch:128674 PROKR2
NCBI Gene:128674 PROKR2
OMIM:607123 PROKR2
UCSC:Q8NFJ6 PROKR2
Reference Transcript
RefSeq:NM_144773.3 PROKR2
RefSeq:XM_017027646.1 PROKR2
Other Identifiers
11737392_at
128674
16916971
234450_PM_at
234450_at
3896263
3896264
3896265
3896266
3896267
3896268
3896269
3896270
3896271
3896272
3896273
3896274
3896280
3896281
3896282
3896283
3896284
8064859
ADDON002761.hg
A_23_P40290
A_23_P412603
GE563592
GO:0004930
GO:0004983
GO:0005515
GO:0005886
GO:0007186
GO:0007218
GO:0007623
GO:0016020
GO:0060089
HMNXSV003039825
HMNXSV003040557
Hs.283834.0.S1_3p_at
ILMN_2043553
PH_hs_0032963
TC20000594.hg
Participates
as a member of
PROKR1,PROKR2 [plasma membrane] (Homo sapiens)
Inferred To
Prokr2 [plasma membrane]
(Mus musculus)
Prokr2 [plasma membrane]
(Rattus norvegicus)
TrissinR [plasma membrane]
(Drosophila melanogaster)
PROKR2 [plasma membrane]
(Bos taurus)
PROKR2 [plasma membrane]
(Gallus gallus)
PROKR2 [plasma membrane]
(Sus scrofa)
prokr1b [plasma membrane]
(Danio rerio)
pcdr-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_658986.1
,
XP_016883135.1
Guide to Pharmacology - Targets
336
ENSEMBL
ENST00000217270
,
ENSP00000504128
,
ENSP00000217270
,
ENST00000678254
OpenTargets
ENSG00000101292
ZINC - Substances
PKR2_HUMAN
ZINC target
Q8NFJ6
PRO
Q8NFJ6
GlyGen
Q8NFJ6
HPA
ENSG00000101292-PROKR2
Pharos - Targets
Q8NFJ6
Orphanet
PROKR2
ZINC - Predictions - Purchasable
PKR2_HUMAN
HMDB Protein
HMDBP07944
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15848 ADIPOQ
1
ADIPOQ [extracellular region]
(R-HSA-1183052)
0.556
3
UniProt:P24593 IGFBP5
5
IGFBP5 [endoplasmic reticulum lumen]
(R-HSA-8956738)
p-IGFBP5 [endoplasmic reticulum lumen]
(R-HSA-8956988)
IGFBP5 [extracellular region]
(R-HSA-381414)
IGFBP5(21-163) [extracellular region]
(R-HSA-381415)
IGFBP5(164-272) [extracellular region]
(R-HSA-381478)
0.556
3
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