Reactome | PROK2 [extracellular region]

PROK2 [extracellular region]

Stable Identifier

R-HSA-444660

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Prokineticin-2, PROK2_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK2 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK2 [extracellular region] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK2 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK2 [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK2 [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK2 [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Prokineticin receptors bind prokineticin (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK2 [extracellular region] (Homo sapiens)
        
        PROKR1,PROKR2:PROK1,PROK2 [plasma membrane] (Homo sapiens)
        
        PROK1,PROK2 [extracellular region] (Homo sapiens)
        
        PROK2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HC23 PROK2

Gene Names

PROK2, BV8

Chain

signal peptide:1-27, chain:28-129

Reference Genes

BioGPS Gene:60675 PROK2

COSMIC (genes):PROK2 PROK2

CTD Gene:60675 PROK2

dbSNP Gene:60675 PROK2

ENSEMBL:ENSG00000163421 PROK2

HGNC:18455 PROK2

KEGG:hsa:60675 PROK2

Monarch:60675 PROK2

NCBI Gene:60675 PROK2

OMIM:607002 PROK2

UCSC:Q9HC23 PROK2

Reference Transcript

Other Identifiers

11732808_a_at

11732809_a_at

16956213

232629_PM_at

232629_at

2682274

2682275

2682278

2682283

2682285

2682286

60675

8088813

89017_at

A_24_P97342

GE88004

GO:0001525

GO:0001664

GO:0001935

GO:0005515

GO:0005576

GO:0006935

GO:0006954

GO:0007186

GO:0007204

GO:0007218

GO:0007283

GO:0007623

GO:0019233

GO:0022414

GO:0043066

GO:0045987

GO:0048511

GO:0050877

HMNXSV003013159

Hs.203181.0.S1_3p_at

ILMN_1775257

PH_hs_0022001

TC03001550.hg

Participates

as a member of

PROK1,PROK2 [extracellular region] (Homo sapiens)

Inferred To

PROK2 [extracellular region] (Bos taurus)

PROK2 [extracellular region] (Canis familiaris)

PROK2 [extracellular region] (Gallus gallus)

PROK2 [extracellular region] (Sus scrofa)

prok2 [extracellular region] (Danio rerio)

Prok2 [extracellular region] (Mus musculus)

Prok2 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_068754.1, NP_001119600.1

ENSEMBL

ENST00000295619, ENSP00000295619, ENSP00000295618, ENST00000353065

OpenTargets

ENSG00000163421

HPA

ENSG00000163421-PROK2

PRO

Q9HC23

Pharos - Targets

Q9HC23

Orphanet

PROK2