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RXFP2 [plasma membrane]
Stable Identifier
R-HSA-444844
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Relaxin receptor 2, RXFP2_HUMAN, GPR106, LGR8
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
RXFP2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Relaxin receptors (Homo sapiens)
Relaxin receptor 2 binds relaxin 2 and INSL3 (Homo sapiens)
RXFP2 [plasma membrane] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WXD0 RXFP2
Gene Names
RXFP2, GPR106, GREAT, LGR8
Chain
chain:1-754
Reference Genes
BioGPS Gene:122042 RXFP2
COSMIC (genes):RXFP2 RXFP2
CTD Gene:122042 RXFP2
dbSNP Gene:122042 RXFP2
ENSEMBL:ENSG00000133105 RXFP2
ENSEMBL_homo_sapiens_GENE:ENSG00000133105.8 RXFP2
HGNC:17318 RXFP2
Monarch:122042 RXFP2
NCBI Gene:122042 RXFP2
OMIM:606655 RXFP2
UCSC:Q8WXD0 RXFP2
Reference Transcript
RefSeq:NM_130806.4 RXFP2
RefSeq:NM_001166058.1 RXFP2
Other Identifiers
11741845_a_at
122042
1553326_PM_at
1553326_at
16773727
3484398
3484399
3484400
3484401
3484403
3484404
3484405
3484406
3484407
3484408
3484409
3484410
3484411
3484412
3484414
3484418
3484420
3484424
3484425
3484426
3484427
3484428
3484429
7968389
A_23_P117261
GE474562
GO:0001556
GO:0004930
GO:0005515
GO:0005886
GO:0007165
GO:0007186
GO:0007189
GO:0007193
GO:0008285
GO:0008528
GO:0008584
GO:0009755
GO:0012501
GO:0016020
GO:0016500
GO:0017046
GO:0022414
GO:0023052
GO:0030154
GO:0043066
GO:0043950
GO:0048856
GO:0060089
HMNXSV003032971
Hs2.348481.1.S1_3p_at
ILMN_1679152
PH_hs_0016790
TC13000106.hg
Participates
as an input of
Relaxin receptor 2 binds relaxin 2 and INSL3 (Homo sapiens)
as a member of
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
as a component of
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
Inferred To
Rxfp2 [plasma membrane]
(Mus musculus)
Rxfp2 [plasma membrane]
(Rattus norvegicus)
Lgr3 [plasma membrane]
(Drosophila melanogaster)
Homologues of RXFP2 [plasma membrane]
(Drosophila melanogaster)
Lgr4 [plasma membrane]
(Drosophila melanogaster)
RXFP2 [plasma membrane]
(Bos taurus)
RXFP2 [plasma membrane]
(Canis familiaris)
RXFP2 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_570718.1
,
NP_001159530.1
Guide to Pharmacology - Targets
352
OpenTargets
ENSG00000133105
HPA
ENSG00000133105-RXFP2
GeneCards
Q8WXD0
ZINC target
Q8WXD0
Ensembl
ENST00000380314
,
ENSP00000369670
,
ENST00000298386
,
ENSG00000133105
,
ENSP00000298386
PRO
Q8WXD0
Pharos - Targets
Q8WXD0
Orphanet
25571
HMDB Protein
HMDBP08172
PDB
2M96
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