L1-EGFR trans-heterodimerization

Stable Identifier
R-HSA-445069
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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L1-EGFR trans-heterodimerization
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L1CAM and EGFR engage in a weak heterophilic trans interaction and this induces EGFR tyrosine kinase activity and its activation. However, this trans interaction alone is not sufficient to induce EGFR autophosphorylation, which requires additional cis type interactions between the two proteins.
Literature References
PubMed ID Title Journal Year
14718570 Activation of EGF receptor kinase by L1-mediated homophilic cell interactions

Islam, R, Kristiansen, LV, Garcia-Alonso, L, Romani, S, Hortsch, M

Mol Biol Cell 2004
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Orthologous Events
L1-EGFR trans-heterodimerization (Caenorhabditis elegans)
L1-EGFR trans-heterodimerization (Mus musculus)
L1-EGFR trans-heterodimerization (Rattus norvegicus)
L1-EGFR trans-heterodimerization (Xenopus tropicalis)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-27)
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