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Go!
SUFU [cytosol]
Stable Identifier
R-HSA-445455
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Suppressor of fused homolog, SUFU_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q7Z412 PEX26
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Degradation of GLI1 by the proteasome (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)
SUFU [cytosol] (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)
SUFU [cytosol] (Homo sapiens)
Degradation of GLI2 by the proteasome (Homo sapiens)
GLI2 is degraded by the proteasome (Homo sapiens)
SUFU [cytosol] (Homo sapiens)
GLI proteins bind SUFU (Homo sapiens)
SUFU [cytosol] (Homo sapiens)
GLI3 is processed to GLI3R by the proteasome (Homo sapiens)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Homo sapiens)
SUFU [cytosol] (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI proteins bind SUFU (Homo sapiens)
SUFU [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UMX1 SUFU
Gene Names
SUFU, UNQ650/PRO1280
Chain
chain:1-484
Reference Genes
BioGPS Gene:51684 SUFU
COSMIC (genes):SUFU SUFU
CTD Gene:51684 SUFU
dbSNP Gene:51684 SUFU
ENSEMBL:ENSG00000107882 SUFU
ENSEMBL_homo_sapiens_GENE:ENSG00000107882.12 SUFU
HGNC:16466 SUFU
KEGG Gene (Homo sapiens):51684 SUFU
Monarch:51684 SUFU
NCBI Gene:51684 SUFU
OMIM:607035 SUFU
UCSC:Q9UMX1 SUFU
Reference Transcript
RefSeq:NM_001178133.1 SUFU
RefSeq:NM_016169.3 SUFU
Other Identifiers
11721036_at
11721037_a_at
11721038_at
11744963_a_at
11759802_at
11762006_at
16708699
222749_PM_at
222749_at
224201_PM_s_at
224201_s_at
224202_PM_at
224202_at
224203_PM_at
224203_at
3261766
3261767
3261770
3261776
3261786
3261787
3261788
3261789
3261790
3261795
3261796
3261797
3261798
3261799
3261800
3261801
3261802
3261803
3261807
3261809
3261810
3261811
3261819
3261821
3261822
3261823
49463_at
51684
7930120
A_14_P117713
A_14_P120695
A_23_P425304
A_24_P149893
A_24_P149902
A_33_P3333030
GE56721
GE82086
GE83749
GO:0000122
GO:0001843
GO:0001947
GO:0003281
GO:0003714
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005929
GO:0006351
GO:0006355
GO:0006886
GO:0006913
GO:0007165
GO:0007224
GO:0007286
GO:0007368
GO:0008013
GO:0008134
GO:0019901
GO:0021513
GO:0021775
GO:0021776
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0035904
GO:0042308
GO:0043226
GO:0043433
GO:0043588
GO:0045668
GO:0045879
GO:0048856
GO:0060976
GO:0097542
GO:0097546
GO:0140110
GO:1990788
GO:2000059
GO:2001040
HMNXSV003025724
HMNXSV003031669
ILMN_1804361
PH_hs_0001856
TC10000759.hg
g6689887_3p_at
g6689893_3p_at
g7025391_3p_at
Participates
as an output of
Gli2is degraded by the proteasome (Homo sapiens)
GLI2 is degraded by the proteasome (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Homo sapiens)
as an input of
GLI proteins bind SUFU (Homo sapiens)
as a component of
GLI:SUFU [cytosol] (Homo sapiens)
Other forms of this molecule
SUFU [ciliary base]
SUFU [ciliary tip]
Inferred To
Su(fu) [cytosol]
(Drosophila melanogaster)
SUFU [cytosol]
(Bos taurus)
SUFU [cytosol]
(Canis familiaris)
SUFU [cytosol]
(Gallus gallus)
SUFU [cytosol]
(Sus scrofa)
sufu [cytosol]
(Danio rerio)
sufu [cytosol]
(Xenopus tropicalis)
Sufu [cytosol]
(Mus musculus)
Sufu [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001171604.1
,
NP_057253.2
OpenTargets
ENSG00000107882
GeneCards
Q9UMX1
HPA
ENSG00000107882-SUFU
Ensembl
ENSP00000358915
,
ENSG00000107882
,
ENST00000369902
,
ENSP00000411597
,
ENST00000369899
,
ENSP00000358918
,
ENST00000423559
PRO
Q9UMX1
Pharos - Targets
Q9UMX1
Orphanet
15569
PDB
4BLD
,
4BL8
,
1M1L
,
4BL9
,
4KMD
,
4KMH
,
4BLB
,
4BLA
,
4KM9
,
4KM8
Interactors (54)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08151 GLI1
9
ub-GLI1 [cytosol]
(R-HSA-5635833)
ub-pS-GLI1 [ciliary base]
(R-HSA-5610514)
pS-GLI1 [ciliary base]
(R-HSA-5610497)
GLI1 [cytosol]
(R-HSA-445457)
p-GLI1 [ciliary tip]
(R-HSA-5635040)
2p-GLI1 [nucleoplasm]
(R-HSA-5635057)
p-GLI1 [nucleoplasm]
(R-HSA-5635042)
GLI1 [ciliary tip]
(R-HSA-5610360)
GLI1 [ciliary base]
(R-HSA-5610357)
0.968
27
UniProt:Q9BV97 ZNF747
1
ZNF747 [nucleoplasm]
(R-HSA-2586596)
0.848
8
UniProt:Q96H86 ZNF764
1
ZNF764 [nucleoplasm]
(R-HSA-3343766)
0.847
9
UniProt:P10071 GLI3
13
ub-2p-GLI3 [nucleoplasm]
(R-HSA-5635060)
GLI3 [cytosol]
(R-HSA-206085)
p-GLI3 [ciliary tip]
(R-HSA-5635048)
2p-GLI3 [nucleoplasm]
(R-HSA-5635052)
p-GLI3 [nucleoplasm]
(R-HSA-5635051)
GLI3 [ciliary tip]
(R-HSA-5610367)
GLI3R [nucleoplasm]
(R-HSA-5610371)
GLI3R [cytosol]
(R-HSA-5610369)
ub-p13S-GLI3 [ciliary base]
(R-HSA-5610506)
p13S-GLI3 [ciliary base]
(R-HSA-5610485)
p10S-GLI3 [ciliary base]
(R-HSA-5610454)
p6S-GLI3 [ciliary base]
(R-HSA-5610492)
GLI3 [ciliary base]
(R-HSA-5610365)
0.773
5
UniProt:Q13515 BFSP2
0.742
6
UniProt:Q96D15 RCN3
0.703
5
UniProt:Q8TBC5 ZSC18
0.666
4
UniProt:Q7Z353 HDX
0.666
4
UniProt:Q9NWS9-2 ZNF446
0.666
4
UniProt:Q86YD7 F90A1
0.643
3
UniProt:P30307 CDC25C
8
p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol]
(R-HSA-8863654)
p-S191-CDC25C [nucleoplasm]
(R-HSA-6802968)
p-S216-CDC25C [cytosol]
(R-HSA-75003)
p-S216-CDC25C [nucleoplasm]
(R-HSA-156496)
CDC25C [nucleoplasm]
(R-HSA-69741)
CDC25C [cytosol]
(R-HSA-157879)
p-S198-CDC25C [cytosol]
(R-HSA-8981697)
p-S198-CDC25C [nucleoplasm]
(R-HSA-156668)
0.643
3
UniProt:O14753 OVOL1
0.641
3
UniProt:P10070 GLI2
11
ub-2p-GLI2 [nucleoplasm]
(R-HSA-5635059)
p4S-GLI2 [ciliary base]
(R-HSA-5610487)
p8S-GLI2 [ciliary base]
(R-HSA-5610494)
p11S-GLI2 [ciliary base]
(R-HSA-5610471)
GLI2 [ciliary tip]
(R-HSA-5610363)
GLI2 [ciliary base]
(R-HSA-5610361)
2p-GLI2 [nucleoplasm]
(R-HSA-5635055)
p-GLI2 [nucleoplasm]
(R-HSA-5635047)
p-GLI2 [ciliary tip]
(R-HSA-5635044)
GLI2 [cytosol]
(R-HSA-445451)
ub-p11S-GLI2 [ciliary base]
(R-HSA-5610501)
0.569
3
UniProt:Q12968 NFATC3
3
p-S265-NFATC3 [cytosol]
(R-HSA-2685614)
p-S265-NFATC3 [nucleoplasm]
(R-HSA-2025988)
p-13S-NFATC3 [cytosol]
(R-HSA-2025920)
0.564
2
UniProt:Q9Y250 LZTS1
0.556
3
UniProt:Q8NC26 ZNF114
1
ZNF114 [nucleoplasm]
(R-HSA-975026)
0.556
3
UniProt:P51114-2 FXR1
0.556
3
UniProt:Q15915 ZIC1
1
ZIC1 [nucleoplasm]
(R-HSA-9731648)
0.556
3
UniProt:Q9Y3S2 ZN330
0.556
3
UniProt:Q7Z3Y8 KRT27
1
KRT27 [cytosol]
(R-HSA-6809587)
0.556
3
IntAct:EBI-22313194 CCSB ORF ID
0.556
3
UniProt:Q9NRI5-2 DISC1
0.556
3
UniProt:Q08117-2 TLE5
0.556
3
UniProt:O43186 CRX
0.556
3
UniProt:Q96JM7-2 L3MBTL3
0.556
3
UniProt:Q53ET0 CRTC2
1
CRTC2 [nucleoplasm]
(R-HSA-8931951)
0.556
5
UniProt:Q8N4C7 STX19
0.556
3
UniProt:Q0D2J5 ZN763
0.556
3
UniProt:Q86VQ0 LCA5
0.556
3
UniProt:Q9P2A4 ABI3
0.556
3
UniProt:Q9UJ55 MAGL2
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:O00746 NME4
1
NME4 [mitochondrial inner membrane]
(R-HSA-60026)
0.556
3
UniProt:O95678 KRT75
1
KRT75 [cytosol]
(R-HSA-6809652)
0.556
3
UniProt:Q86V38 Q86V38
0.556
3
UniProt:Q96GZ6 S41A3
0.556
3
UniProt:Q92876 KLK6
0.556
3
UniProt:O14978 ZNF263
1
ZNF263 [nucleoplasm]
(R-HSA-1027393)
0.553
2
UniProt:Q8NEA6 GLIS3
0.553
3
UniProt:Q9NPA3 MID1IP1
1
MID1IP1 [cytosol]
(R-HSA-8867328)
0.547
3
UniProt:Q9NRP7 STK36
0.536
3
UniProt:P12644 BMP4
4
BMP4 [extracellular region]
(R-HSA-8858573)
BMP4 [endoplasmic reticulum lumen]
(R-HSA-8956775)
p-BMP4 [endoplasmic reticulum lumen]
(R-HSA-8956944)
BMP4(20-408) [extracellular region]
(R-HSA-2396280)
0.527
3
UniProt:Q7Z6J8 UBE3D
1
UBE3D [cytosol]
(R-HSA-8851647)
0.527
2
UniProt:P30837 ALDH1B1
1
ALDH1B1 [mitochondrial matrix]
(R-HSA-5696097)
0.527
2
UniProt:O14771 ZNF213
1
ZNF213 [nucleoplasm]
(R-HSA-1027351)
0.527
3
UniProt:Q92611 EDEM1
1
EDEM1 [endoplasmic reticulum quality control compartment]
(R-HSA-381083)
0.527
2
UniProt:Q1X8D7 LRC36
0.527
2
UniProt:O60293 ZC3H1
0.527
3
UniProt:Q9Y466 NR2E1
1
NR2E1 [nucleoplasm]
(R-HSA-376207)
0.527
2
UniProt:O95157 NXPH3
0.527
3
UniProt:Q9Y234 LIPT1
1
LIPT1 [mitochondrial matrix]
(R-HSA-6792623)
0.527
2
UniProt:Q16822 PCK2
1
PCK2 [mitochondrial matrix]
(R-HSA-372815)
0.527
3
UniProt:Q7Z412 PEX26
2
PEX26 [cytosol]
(R-HSA-9603779)
PEX26 [peroxisomal membrane]
(R-HSA-9033092)
0.508
2
UniProt:Q0VGT2 Gli2
13
phospho-Gli2 [nucleoplasm]
(R-MMU-5635059)
ub-p11S-Gli2 [cytosol]
(R-MMU-5610503)
p11S-Gli2 [cytosol]
(R-MMU-5610476)
p8S-Gli2 [cytosol]
(R-MMU-5610496)
p4S-Gli2 [cytosol]
(R-MMU-5610489)
Gli2 [cytosol]
(R-MMU-5610376)
Gli2 [nucleoplasm]
(R-MMU-3900178)
Gli2 [cytosol]
(R-MMU-445451)
phospho-Gli2 [ciliary tip]
(R-MMU-5635044)
phospho-Gli2 [nucleoplasm]
(R-MMU-5635047)
phospho-Gli2 [nucleoplasm]
(R-MMU-5635055)
Gli2 [ciliary base]
(R-MMU-5610361)
Gli2 [ciliary tip]
(R-MMU-5610363)
0.463
3
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