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GLI1 [cytosol]
Stable Identifier
R-HSA-445457
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Zinc finger protein GLI1, GLI1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)
GLI1 [cytosol] (Homo sapiens)
GLI proteins bind SUFU (Homo sapiens)
GLI1,2,3 [cytosol] (Homo sapiens)
GLI1 [cytosol] (Homo sapiens)
GLI:SUFU [cytosol] (Homo sapiens)
GLI1,2,3 [cytosol] (Homo sapiens)
GLI1 [cytosol] (Homo sapiens)
The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Homo sapiens)
GLI:SUFU [cytosol] (Homo sapiens)
GLI1,2,3 [cytosol] (Homo sapiens)
GLI1 [cytosol] (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI proteins bind SUFU (Homo sapiens)
GLI1,2,3 [cytosol] (Homo sapiens)
GLI1 [cytosol] (Homo sapiens)
GLI:SUFU [cytosol] (Homo sapiens)
GLI1,2,3 [cytosol] (Homo sapiens)
GLI1 [cytosol] (Homo sapiens)
GLI proteins bind promoters of Hh responsive genes to promote transcription (Homo sapiens)
Hh-dependent expression of GLI1 gene (Homo sapiens)
GLI1 [cytosol] (Homo sapiens)
GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Homo sapiens)
GLI:SUFU [cytosol] (Homo sapiens)
GLI1,2,3 [cytosol] (Homo sapiens)
GLI1 [cytosol] (Homo sapiens)
NUMB:ITCH binds GLI1 (Homo sapiens)
GLI1 [cytosol] (Homo sapiens)
GLI1:NUMB:ITCH [cytosol] (Homo sapiens)
GLI1 [cytosol] (Homo sapiens)
NUMB:ITCH ubiquitinates GLI1 (Homo sapiens)
GLI1:NUMB:ITCH [cytosol] (Homo sapiens)
GLI1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08151 GLI1
Gene Names
GLI1, GLI
Chain
chain:1-1106
Reference Genes
COSMIC (genes):GLI1 GLI1
dbSNP Gene:2735 GLI1
ENSEMBL:ENSG00000111087 GLI1
Participates
as an output of
Hh-dependent expression of GLI1 gene (Homo sapiens)
Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)
as a component of
GLI1:NUMB:ITCH [cytosol] (Homo sapiens)
GLI1-Sufu [cytosol] (Homo sapiens)
as an input of
NUMB:ITCH binds GLI1 (Homo sapiens)
as a member of
GLI1,2,3 [cytosol] (Homo sapiens)
Other forms of this molecule
ub-GLI1 [cytosol]
ub-pS-GLI1 [ciliary base]
pS-GLI1 [ciliary base]
p-GLI1 [ciliary tip]
2p-GLI1 [nucleoplasm]
p-GLI1 [nucleoplasm]
GLI1 [ciliary base]
GLI1 [ciliary tip]
Inferred To
ci [cytosol]
(Drosophila melanogaster)
gli1 [cytosol]
(Xenopus tropicalis)
GLI1 [cytosol]
(Bos taurus)
GLI1 [cytosol]
(Canis familiaris)
GLI1 [cytosol]
(Gallus gallus)
GLI1 [cytosol]
(Sus scrofa)
Gli1 [cytosol]
(Mus musculus)
Gli1 [cytosol]
(Rattus norvegicus)
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UMX1 SUFU
3
SUFU [ciliary base]
(R-HSA-5610424)
SUFU [cytosol]
(R-HSA-445455)
SUFU [ciliary tip]
(R-HSA-5610426)
0.968
27
UniProt:Q9QZS3-2 NUMB
0.611
4
UniProt:Q96J02 ITCH
2
Ub-C871-ITCH [cytosol]
(R-HSA-8864515)
ITCH [cytosol]
(R-HSA-975995)
0.602
4
UniProt:Q9UMX1-2 SUFU
0.571
4
UniProt:Q96CN9 GCC1
1
GCC1 [cytosol]
(R-HSA-6813877)
0.556
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.556
3
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.556
3
UniProt:Q8IWZ5 TRI42
0.556
3
UniProt:P29972 AQP1
1
AQP1 [plasma membrane]
(R-HSA-431700)
0.556
3
UniProt:P53673 CRBA4
0.556
3
UniProt:Q8NEC5 CATSPER1
1
CATSPER1 [plasma membrane]
(R-HSA-2534335)
0.556
3
UniProt:P23443-2 RPS6KB1
0.544
2
UniProt:Q9NRP7 STK36
0.536
2
UniProt:P46684 ZIC1
0.524
2
UniProt:P40337 VHL
3
monoSUMO1-K159,171,196-VHL [nucleoplasm]
(R-HSA-4551697)
VHL [nucleoplasm]
(R-HSA-1234127)
VHL [cytosol]
(R-HSA-391423)
0.463
2
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