Reactome | TCF12 [nucleoplasm]

TCF12 [nucleoplasm]

Stable Identifier

R-HSA-445670

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HTF4/HEB, Transcription factor 12, HTF4_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
        
        MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TCF3,TCF12 [nucleoplasm] (Homo sapiens)
        
        TCF12 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TCF3,TCF12 [nucleoplasm] (Homo sapiens)
        
        TCF12 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TCF3,TCF12 [nucleoplasm] (Homo sapiens)
        
        TCF12 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TCF3,TCF12 [nucleoplasm] (Homo sapiens)
        
        TCF12 [nucleoplasm] (Homo sapiens)
        
        RUNX1 binds the core TAL1 complex (Homo sapiens)
        
        RUNX1:CBFB:TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TCF3,TCF12 [nucleoplasm] (Homo sapiens)
        
        TCF12 [nucleoplasm] (Homo sapiens)
        
        TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TCF3,TCF12 [nucleoplasm] (Homo sapiens)
        
        TCF12 [nucleoplasm] (Homo sapiens)
        
        RUNX1-containing TAL1 complex binds the MYB gene enhancer (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TCF3,TCF12 [nucleoplasm] (Homo sapiens)
        
        TCF12 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TCF3,TCF12 [nucleoplasm] (Homo sapiens)
        
        TCF12 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TCF3,TCF12 [nucleoplasm] (Homo sapiens)
        
        TCF12 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
        
        TCF3,TCF12 [nucleoplasm] (Homo sapiens)
        
        TCF12 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99081 TCF12

Gene Names

TCF12, BHLHB20, HEB, HTF4

Chain

chain:1-682

Reference Genes

BioGPS Gene:6938 TCF12

COSMIC (genes):TCF12 TCF12

CTD Gene:6938 TCF12

dbSNP Gene:6938 TCF12

ENSEMBL:ENSG00000140262 TCF12

HGNC:11623 TCF12

KEGG:hsa:6938 TCF12

Monarch:6938 TCF12

NCBI Gene:6938 TCF12

OMIM:600480 TCF12

UCSC:Q99081 TCF12

Reference Transcript

Participates

as a candidate of

phospho-E proteins [nucleoplasm] (Homo sapiens)

as a member of

TCF3,TCF12 [nucleoplasm] (Homo sapiens)

as an input of

p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter (Homo sapiens)

as a component of

VGF gene:p-CREB:p-ATFs:ASCL1:TCF12:EP300 [nucleoplasm] (Homo sapiens)

Inferred To

tcf12 [nucleoplasm] (Danio rerio)

da [nucleoplasm] (Drosophila melanogaster)

hlh-2 [nucleoplasm] (Caenorhabditis elegans)

Tcf12 [nucleoplasm] (Mus musculus)

Tcf12 [nucleoplasm] (Rattus norvegicus)

TCF12 [nucleoplasm] (Bos taurus)

TCF12 [nucleoplasm] (Canis familiaris)

TCF12 [nucleoplasm] (Gallus gallus)

TCF12 [nucleoplasm] (Sus scrofa)

Cross References

OpenTargets

ENSG00000140262

ENSEMBL

ENST00000343827, ENST00000557843, ENSP00000388940, ENSG00000140262, ENSP00000331057, ENST00000438423, ENSP00000444696, ENSP00000267811, ENST00000537840, ENST00000267811, ENST00000333725, ENSP00000453737, ENSP00000342459

GeneCards

TCF12

HPA

ENSG00000140262-TCF12

PRO

Q99081

Pharos - Targets

Q99081

GlyGen

Q99081

Orphanet

TCF12

PDB

4JOL, 2KNH

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.831	7
UniProt:Q9Y4Z2 NEUROG3	1	NEUROG3 [nucleoplasm] (R-HSA-189530)	0.743	6
UniProt:Q96MH2 HEXI2			0.743	6
UniProt:Q02535 ID3	1	ID3 [nucleoplasm] (R-HSA-9613379)	0.742	5
UniProt:Q02363 ID2	1	ID2 [nucleoplasm] (R-HSA-452391)	0.678	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.666	4
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.666	4
UniProt:Q9UJX0 OSGI1			0.666	4
UniProt:Q6XD76 ASCL4			0.666	4
UniProt:Q8WVJ9 TWIST2	1	TWIST2 [nucleoplasm] (R-HSA-445444)	0.666	5
UniProt:Q9NZD8 SPG21			0.666	4
UniProt:P42773 CDKN2C	1	CDKN2C [cytosol] (R-HSA-182572)	0.666	5
UniProt:P0DTD1-PRO_0000449629 REP			0.659	3
UniProt:P23409 MYF6	1	MYF6 [nucleoplasm] (R-HSA-445435)	0.632	3
UniProt:Q548N1 Q548N1			0.556	3
UniProt:Q96MC5 MERB1			0.556	3
UniProt:Q96S90 LYSM1			0.556	3
UniProt:P30626 SRI	1	SRI [sarcoplasmic reticulum membrane] (R-HSA-5490313)	0.556	3
UniProt:Q3B7T1-5 EDRF1			0.556	3
UniProt:Q9UJ70 NAGK	1	NAGK [cytosol] (R-HSA-6803742)	0.556	3
UniProt:P42229 STAT5A	4	p-Y694-STAT5A [cytosol] (R-HSA-507936) STAT5A [cytosol] (R-HSA-380747) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) STAT5A [nucleoplasm] (R-HSA-9701901)	0.556	3
UniProt:Q8IYR0 CF206			0.556	3
UniProt:Q8IUR7 ARMC8	4	ARMC8 [tertiary granule lumen] (R-HSA-6800958) ARMC8 [extracellular region] (R-HSA-6806294) ARMC8 [specific granule lumen] (R-HSA-6799508) ARMC8 [cytosol] (R-HSA-9861612)	0.556	3
UniProt:Q8NDC4 MORN4			0.556	3
UniProt:O75716 STK16			0.556	3
UniProt:Q6P2C6 Q6P2C6			0.556	3
UniProt:P47897-2 QARS1			0.556	3
UniProt:O75575 CRCP	2	CRCP [cytosol] (R-HSA-5420849) CRCP [nucleoplasm] (R-HSA-5420844)	0.556	3
UniProt:Q8WVZ3 Q8WVZ3			0.556	3
UniProt:Q9BPY8 HOPX	1	HOPX [nucleoplasm] (R-HSA-9728002)	0.556	3
UniProt:Q6ZMU5 TRIM72	1	TRIM72 [cytoplasmic vesicle membrane] (R-HSA-5263653)	0.556	3
UniProt:Q99598 TSNAX	1	TSNAX [cytosol] (R-HSA-5216130)	0.556	3
UniProt:O60336 MABP1			0.556	3
UniProt:Q9NX04 AIRIM			0.556	3
UniProt:Q1RLL8 Q1RLL8			0.556	3
UniProt:Q16559 TAL2			0.547	2
UniProt:P41134 ID1	1	ID1 [nucleoplasm] (R-HSA-2534101)	0.547	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.527	3
UniProt:P15173 MYOG	1	MYOG [nucleoplasm] (R-HSA-445160)	0.499	2