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TCF12 [nucleoplasm]
Stable Identifier
R-HSA-445670
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HTF4/HEB, Transcription factor 12, HTF4_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P42229 STAT5A
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
NGF-stimulated transcription (Homo sapiens)
p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter (Homo sapiens)
TCF12 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99081 TCF12
Gene Names
TCF12, BHLHB20, HEB, HTF4
Chain
chain:1-682
Reference Genes
BioGPS Gene:6938 TCF12
COSMIC (genes):TCF12 TCF12
CTD Gene:6938 TCF12
dbSNP Gene:6938 TCF12
ENSEMBL:ENSG00000140262 TCF12
ENSEMBL_homo_sapiens_GENE:ENSG00000140262.18 TCF12
HGNC:11623 TCF12
KEGG Gene (Homo sapiens):6938 TCF12
Monarch:6938 TCF12
NCBI Gene:6938 TCF12
OMIM:600480 TCF12
UCSC:Q99081 TCF12
Reference Transcript
RefSeq:NM_001306220.2 TCF12
RefSeq:NM_001322159.1 TCF12
RefSeq:NM_001322157.1 TCF12
RefSeq:NM_001322165.1 TCF12
RefSeq:NM_207036.1 TCF12
RefSeq:NM_207038.1 TCF12
RefSeq:NM_001322151.1 TCF12
RefSeq:NM_001322162.1 TCF12
RefSeq:NM_003205.3 TCF12
RefSeq:NM_207037.1 TCF12
RefSeq:NM_207040.1 TCF12
Other Identifiers
11720580_a_at
11720581_s_at
11720582_a_at
11720583_s_at
11720584_x_at
11726957_a_at
11745727_a_at
11745728_s_at
11745861_a_at
11745862_x_at
11752247_a_at
16801329
208986_PM_at
208986_at
238041_PM_at
238041_at
33348_at
3595098
3595100
3595104
3595134
3595146
3595170
3595178
3595179
3595187
3595188
3595191
3595192
3595194
3595195
3595205
3595208
3595211
3595213
3595217
3595218
3595220
3595223
3595228
3595229
3595230
3595231
3595232
3595233
3595234
3595235
3595236
54311_at
6938
7983843
A_14_P120408
A_14_P138012
A_23_P151930
A_24_P13663
A_24_P82142
GE58299
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0001228
GO:0002376
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0006351
GO:0006355
GO:0006357
GO:0006955
GO:0007399
GO:0007517
GO:0010467
GO:0010628
GO:0016607
GO:0030154
GO:0035497
GO:0043226
GO:0043231
GO:0043425
GO:0045666
GO:0045893
GO:0045944
GO:0046332
GO:0046982
GO:0046983
GO:0048856
GO:0070888
GO:0071837
GO:0090575
GO:0097210
GO:0140110
GO:0140297
GO:1990837
HMNXSV003053012
Hs.21704.0.S2_3p_at
Hs.82572.0.A1_3p_at
ILMN_1669832
ILMN_1772614
ILMN_2314007
M83233_at
PH_hs_0025656
TC15000435.hg
Participates
as a candidate of
phospho-E proteins [nucleoplasm] (Homo sapiens)
as a member of
TCF3,TCF12 [nucleoplasm] (Homo sapiens)
as an input of
p-CREB, ASCL1, TCF12, ATFs and p300 bind the VGF promoter (Homo sapiens)
as a component of
VGF gene:p-CREB:p-ATFs:ASCL1:TCF12:EP300 [nucleoplasm] (Homo sapiens)
Inferred To
tcf12 [nucleoplasm]
(Danio rerio)
da [nucleoplasm]
(Drosophila melanogaster)
hlh-2 [nucleoplasm]
(Caenorhabditis elegans)
Tcf12 [nucleoplasm]
(Mus musculus)
Tcf12 [nucleoplasm]
(Rattus norvegicus)
TCF12 [nucleoplasm]
(Bos taurus)
TCF12 [nucleoplasm]
(Canis familiaris)
TCF12 [nucleoplasm]
(Gallus gallus)
TCF12 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_996919.1
,
NP_001309091.1
,
NP_001309094.1
,
NP_003196.1
,
NP_001309080.1
,
NP_996920.1
,
NP_996921.1
,
NP_001293149.1
,
NP_001309088.1
,
NP_001309086.1
,
NP_996923.1
OpenTargets
ENSG00000140262
HPA
ENSG00000140262-TCF12
GeneCards
Q99081
Ensembl
ENSP00000453737
,
ENST00000537840
,
ENSG00000140262
,
ENSP00000342459
,
ENST00000557843
,
ENSP00000267811
,
ENST00000438423
,
ENST00000343827
,
ENSP00000444696
,
ENSP00000331057
,
ENST00000267811
,
ENST00000333725
,
ENSP00000388940
PRO
Q99081
Pharos - Targets
Q99081
Orphanet
21977
PDB
2KNH
,
4JOL
Interactors (39)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17542 TAL1
1
TAL1 [nucleoplasm]
(R-HSA-8956511)
0.831
7
UniProt:Q96MH2 HEXI2
0.743
6
UniProt:Q9Y4Z2 NEUROG3
1
NEUROG3 [nucleoplasm]
(R-HSA-189530)
0.743
6
UniProt:Q02535 ID3
1
ID3 [nucleoplasm]
(R-HSA-9613379)
0.742
5
UniProt:Q02363 ID2
1
ID2 [nucleoplasm]
(R-HSA-452391)
0.678
3
UniProt:P42773 CDKN2C
1
CDKN2C [cytosol]
(R-HSA-182572)
0.666
5
UniProt:Q9NZD8 SPG21
0.666
4
UniProt:Q8WVJ9 TWIST2
1
TWIST2 [nucleoplasm]
(R-HSA-445444)
0.666
5
UniProt:Q6XD76 ASCL4
0.666
4
UniProt:Q9UJX0 OSGI1
0.666
4
UniProt:P25786 PSMA1
2
PSMA1 [nucleoplasm]
(R-HSA-174333)
PSMA1 [cytosol]
(R-HSA-68724)
0.666
4
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.666
4
UniProt:P0DTD1-PRO_0000449629 REP
0.659
3
UniProt:P23409 MYF6
1
MYF6 [nucleoplasm]
(R-HSA-445435)
0.632
3
UniProt:Q1RLL8 Q1RLL8
0.556
3
UniProt:Q9NX04 AIRIM
0.556
3
UniProt:O60336 MABP1
0.556
3
UniProt:Q99598 TSNAX
1
TSNAX [cytosol]
(R-HSA-5216130)
0.556
3
UniProt:Q9BPY8 HOPX
1
HOPX [nucleoplasm]
(R-HSA-9728002)
0.556
3
UniProt:Q8WVZ3 Q8WVZ3
0.556
3
UniProt:O75575 CRCP
2
CRCP [nucleoplasm]
(R-HSA-5420844)
CRCP [cytosol]
(R-HSA-5420849)
0.556
3
UniProt:P47897-2 QARS1
0.556
3
UniProt:Q6P2C6 Q6P2C6
0.556
3
UniProt:O75716 STK16
0.556
3
UniProt:Q8NDC4 MORN4
0.556
3
UniProt:Q8IUR7 ARMC8
4
ARMC8 [specific granule lumen]
(R-HSA-6799508)
ARMC8 [extracellular region]
(R-HSA-6806294)
ARMC8 [tertiary granule lumen]
(R-HSA-6800958)
ARMC8 [cytosol]
(R-HSA-9861612)
0.556
3
UniProt:Q8IYR0 CF206
0.556
3
UniProt:P42229 STAT5A
4
STAT5A [nucleoplasm]
(R-HSA-9701901)
p-Y694-STAT5A [nucleoplasm]
(R-HSA-507995)
p-Y694-STAT5A [cytosol]
(R-HSA-507936)
STAT5A [cytosol]
(R-HSA-380747)
0.556
3
UniProt:Q9UJ70 NAGK
1
NAGK [cytosol]
(R-HSA-6803742)
0.556
3
UniProt:Q3B7T1-5 EDRF1
0.556
3
UniProt:P30626 SRI
1
SRI [sarcoplasmic reticulum membrane]
(R-HSA-5490313)
0.556
3
UniProt:Q96S90 LYSM1
0.556
3
UniProt:Q96MC5 MERB1
0.556
3
UniProt:Q548N1 Q548N1
0.556
3
UniProt:Q6ZMU5 TRIM72
1
TRIM72 [cytoplasmic vesicle membrane]
(R-HSA-5263653)
0.556
3
UniProt:Q16559 TAL2
0.547
2
UniProt:P41134 ID1
1
ID1 [nucleoplasm]
(R-HSA-2534101)
0.547
3
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.527
3
UniProt:P15173 MYOG
1
MYOG [nucleoplasm]
(R-HSA-445160)
0.499
2
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