Reactome | TCF4 [nucleoplasm]

TCF4 [nucleoplasm]

Stable Identifier

R-HSA-445672

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E2-2/ITF-2, Transcription factor 4, ITF2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGFBR3 (Homo sapiens)
    - TGFBR3 expression (Homo sapiens)
      - Binding of MyoD to TGFBR3 gene promoter (Homo sapiens)
        
        MyoD:TGFBR3 gene [nucleoplasm] (Homo sapiens)
        
        Myod:phospho-E heterodimers [nucleoplasm] (Homo sapiens)
        
        phospho-E proteins [nucleoplasm] (Homo sapiens)
        
        TCF4 [nucleoplasm] (Homo sapiens)
        
        Myod:phospho-E heterodimers [nucleoplasm] (Homo sapiens)
        
        phospho-E proteins [nucleoplasm] (Homo sapiens)
        
        TCF4 [nucleoplasm] (Homo sapiens)
      - TGFBR3 transcription (Homo sapiens)
        
        MyoD:TGFBR3 gene [nucleoplasm] (Homo sapiens)
        
        Myod:phospho-E heterodimers [nucleoplasm] (Homo sapiens)
        
        phospho-E proteins [nucleoplasm] (Homo sapiens)
        
        TCF4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P15884 TCF4

Gene Names

TCF4, BHLHB19, ITF2, SEF2

Chain

chain:1-667

Reference Genes

COSMIC (genes):TCF4 TCF4

dbSNP Gene:6925 TCF4

ENSEMBL:ENSG00000196628 TCF4

Participates

as a candidate of

phospho-E proteins [nucleoplasm] (Homo sapiens)

Inferred To

da [nucleoplasm] (Drosophila melanogaster)

Tcf4 [nucleoplasm] (Mus musculus)

Tcf4 [nucleoplasm] (Rattus norvegicus)

hlh-2 [nucleoplasm] (Caenorhabditis elegans)

TCF4 [nucleoplasm] (Bos taurus)

TCF4 [nucleoplasm] (Canis familiaris)

TCF4 [nucleoplasm] (Gallus gallus)

TCF4 [nucleoplasm] (Sus scrofa)

Interactors (47)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.94	22
UniProt:Q15672 TWIST1	1	TWIST1 [nucleoplasm] (R-HSA-445442)	0.845	9
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.8	7
UniProt:P47928 ID4	1	ID4 [nucleoplasm] (R-HSA-3701048)	0.725	5
UniProt:P50553 ASCL1	1	ASCL1 [nucleoplasm] (R-HSA-212402)	0.725	8
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.689	5
UniProt:P61296 HAND2	1	HAND2 [nucleoplasm] (R-HSA-9007820)	0.666	4
UniProt:P41134 ID1	1	ID1 [nucleoplasm] (R-HSA-2534101)	0.659	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.564	2
UniProt:Q96AC1 FERMT2	1	FERMT2 [cytosol] (R-HSA-430275)	0.558	6
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:Q9GZQ4 NMUR2	1	NMUR2 [plasma membrane] (R-HSA-964816)	0.556	3
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:O43929 ORC4	1	ORC4 [nucleoplasm] (R-HSA-68519)	0.556	3
UniProt:Q9Y316 MEMO1	1	MEMO1 [cytosol] (R-HSA-6785630)	0.556	3
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.556	3
UniProt:Q9BZE9 ASPSCR1	1	ASPSCR1 [cytoplasmic vesicle membrane] (R-HSA-1449582)	0.556	3
UniProt:Q5SY16 NOL9	1	NOL9 [nucleoplasm] (R-HSA-6791216)	0.556	3
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.556	3
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.556	3
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q9UIL1 SCOC	1	SCOC [cytosol] (R-HSA-6813911)	0.556	3
UniProt:Q9Y3C6 PPIL1	1	PPIL1 [nucleoplasm] (R-HSA-8867892)	0.556	3
UniProt:Q13541 EIF4EBP1	2	p-T37,T46-EIF4EBP1 [cytosol] (R-HSA-165685) EIF4EBP1 [cytosol] (R-HSA-72580)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.556	3
UniProt:P17252 PRKCA	8	PRKCA [cytosol] (R-HSA-58196) PRKCA [plasma membrane] (R-HSA-156469) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.556	3
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.556	3
UniProt:Q96FJ0 STAMBPL1	1	STAMBPL1 [cytosol] (R-HSA-6783264)	0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:Q92888 ARHGEF1	1	ARHGEF1 [cytosol] (R-HSA-114526)	0.556	3
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.556	3
UniProt:Q8NFF5 FLAD1	1	FLAD1 [cytosol] (R-HSA-196980)	0.556	3
UniProt:P21281 ATP6V1B2	1	ATP6V1B2 [cytosol] (R-HSA-912598)	0.556	3
UniProt:Q9UPN9 TRIM33	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.527	3
UniProt:Q0VG99 MESP2	1	MESP2 [nucleoplasm] (R-HSA-9793805)	0.527	2
UniProt:Q13562 NEUROD1	1	NEUROD1 [nucleoplasm] (R-HSA-186689)	0.527	2
UniProt:Q9Y4Z2 NEUROG3	1	NEUROG3 [nucleoplasm] (R-HSA-189530)	0.527	2
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.527	3
UniProt:Q61473 Sox17	2	Sox17 [nucleoplasm] (R-MMU-9823740) Sox17 [nucleoplasm] (R-MMU-5625834)	0.499	5
UniProt:P26233 ctnnb1	1	ctnnb1 [nucleoplasm] (R-XLA-9835531)	0.499	2

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