Reactome | Myosin Binds ATP

Myosin Binds ATP

Stable Identifier

R-HSA-445700

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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With the expulsion of ADP from the nucleotide binding pocket, ATP, if available will immediately bind myosin. When bound to ATP, the myosin head is in its low-energy configuration and the cross-bridge with the actin filament is disrupted.

Literature References

PubMed ID	Title	Journal	Year
2526655	Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells Kumar, CC, Leibowitz, PJ, Zavodny, PJ, Mohan, SR, Narula, SK	Biochemistry	1989
3780718	Isoforms of myosin and actin in human, monkey and rat myometrium. Comparison of pregnant and non-pregnant uterus proteins d'Albis, A, Ropert, S, Janmot, C, Cavaillé, F	Eur J Biochem	1986
2764880	The distribution of heavy-chain isoforms of myosin in airways smooth muscle from adult and neonate humans Mohammad, MA, Sparrow, MP	Biochem J	1989