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Myr82K-Myr83K-IL1A [extracellular region]
Stable Identifier
R-HSA-445746
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
2xMyri-IL1A, IL1A, Interleukin-1 alpha, IL1A_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P27930 IL1R2
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
AP-1 stimulates IL1A transcription (Homo sapiens)
Myr82K-Myr83K-IL1A [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01583 IL1A
Gene Names
IL1A, IL1F1
Chain
propeptide:1-112, chain:113-271
Reference Genes
BioGPS Gene:3552 IL1A
COSMIC (genes):IL1A IL1A
CTD Gene:3552 IL1A
dbSNP Gene:3552 IL1A
ENSEMBL:ENSG00000115008 IL1A
ENSEMBL_homo_sapiens_GENE:ENSG00000115008.6 IL1A
HGNC:5991 IL1A
KEGG Gene (Homo sapiens):3552 IL1A
Monarch:3552 IL1A
NCBI Gene:3552 IL1A
OMIM:147760 IL1A
UCSC:P01583 IL1A
Reference Transcript
RefSeq:NM_000575.4 IL1A
Other Identifiers
11725198_at
16901974
210118_PM_s_at
210118_s_at
2571484
2571485
2571486
2571487
2571488
2571489
2571491
2571492
2571493
2571494
2571496
3552
8054712
A_23_P72096
GE563350
GO:0000278
GO:0001660
GO:0001666
GO:0001819
GO:0002248
GO:0002376
GO:0005125
GO:0005149
GO:0005507
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006629
GO:0006883
GO:0006915
GO:0006954
GO:0006955
GO:0007010
GO:0007155
GO:0007283
GO:0007507
GO:0008285
GO:0009986
GO:0010033
GO:0010193
GO:0010243
GO:0010332
GO:0010575
GO:0010628
GO:0010893
GO:0012501
GO:0014070
GO:0019221
GO:0022414
GO:0023052
GO:0030154
GO:0031424
GO:0032308
GO:0032496
GO:0032743
GO:0032755
GO:0032760
GO:0032874
GO:0032956
GO:0033092
GO:0033591
GO:0034605
GO:0035234
GO:0042060
GO:0043123
GO:0043226
GO:0045766
GO:0045840
GO:0045944
GO:0046330
GO:0046688
GO:0048018
GO:0048856
GO:0048870
GO:0050714
GO:0051781
GO:0055065
GO:0070374
GO:0071222
GO:0097192
GO:0098772
GO:0140014
GO:1902624
GO:1904445
GO:2001240
HMNXSV003036315
ILMN_1658483
PH_hs_0000235
TC02002218.hg
g186277_3p_a_at
Participates
as a member of
IL4,IL13-downregulated extracellular proteins [extracellular region] (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A [extracellular region] (Homo sapiens)
as an output of
AP-1 stimulates IL1A transcription (Homo sapiens)
as a candidate of
Interleukin-1 family [extracellular region] (Homo sapiens)
Other forms of this molecule
IL1A(1-112) [cytosol]
2xMyri-IL1A [cytosol]
IL1A(1-271) [cytosol]
Inferred To
il1fma [extracellular region]
(Danio rerio)
Homologues of Myr82K-Myr83K-IL1A [extracellular region]
(Xenopus tropicalis)
il-1beta [extracellular region]
(Gallus gallus)
LOC105946938 [extracellular region]
(Xenopus tropicalis)
IL1A [extracellular region]
(Bos taurus)
IL1A [extracellular region]
(Canis familiaris)
IL1A [extracellular region]
(Sus scrofa)
il1b [extracellular region]
(Xenopus tropicalis)
Il1a [extracellular region]
(Mus musculus)
Il1a [extracellular region]
(Rattus norvegicus)
Modified Residues
Name
N6-myristoyl-L-lysine at 82
Coordinate
82
PsiMod Name
N6-myristoyl-L-lysine [MOD:00087]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-myristoyl-L-lysine.
Name
N6-myristoyl-L-lysine at 83
Coordinate
83
PsiMod Name
N6-myristoyl-L-lysine [MOD:00087]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-myristoyl-L-lysine.
Cross References
RefSeq
NP_000566.3
OpenTargets
ENSG00000115008
GeneCards
P01583
HPA
ENSG00000115008-IL1A
Ensembl
ENST00000263339
,
ENSG00000115008
,
ENSP00000263339
PRO
P01583
Pharos - Targets
P01583
PDB
5UC6
,
2L5X
,
2KKI
,
2ILA
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27930 IL1R2
1
IL1R2 [plasma membrane]
(R-HSA-197598)
0.661
4
UniProt:O00165 HAX1
0.621
3
UniProt:P50222 MEOX2
0.556
3
UniProt:O60684 KPNA6
2
KPNA6 [nucleoplasm]
(R-HSA-9734665)
KPNA6 [cytosol]
(R-HSA-9734672)
0.556
3
UniProt:P29466 CASP1
5
CASP1(1-119) [cytosol]
(R-HSA-448680)
CASP1(120-297) [cytosol]
(R-HSA-448686)
CASP1(317-404) [cytosol]
(R-HSA-448704)
CASP1(298-316) [cytosol]
(R-HSA-448674)
CASP1(1-404) [cytosol]
(R-HSA-448692)
0.524
3
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