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IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane]
Stable Identifier
R-HSA-445755
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin-1 receptor type 1:Interleukin-1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP binds MYD88 homodimer (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IRAK4 is activated by autophosphorylation (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IRAK4 phosphorylates IRAK1 (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IRAK4-activated IRAK1 autophosphorylates (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
The Interleukin 1 receptor complex binds Tollip (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane] (Homo sapiens)
Participants
components
IL1B,Myr82K-Myr83K-IL1A [extracellular region]
(Homo sapiens)
IL1R1 [plasma membrane]
(Homo sapiens)
Participates
as an output of
IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Homo sapiens)
as a component of
IL1R1:IL1:IL1RAP [plasma membrane] (Homo sapiens)
as an input of
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Homo sapiens)
Inferred To
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane]
(Bos taurus)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane]
(Canis familiaris)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane]
(Gallus gallus)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane]
(Mus musculus)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane]
(Rattus norvegicus)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane]
(Sus scrofa)
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane]
(Xenopus tropicalis)
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