IL1 receptor antagonist protein binds Interleukin 1 receptors

Stable Identifier
R-HSA-445757
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The interleukin 1 receptor antagonist protein (ILRAP or IL1RN) is a member of the IL1 family that binds to IL1R1 (and with much lower affinity IL1R2) but does not elicit a signaling response. By competing with IL1 for IL1R1 binding ILRAP acts as a natural antagonist, inhibiting the biological actions of both agonist forms of IL1 (IL1 alpha and IL1 beta).
Literature References
PubMed ID Title Journal Year
2139180 Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

Bienkowski, MJ, Deibel MR, Jr, Laborde, AL, McEwan, RN, Slightom, JL, Tomich, CS, Dunn, CJ, Carter, DB, Sun, FF, Berger, AE

Nature 1990
1828071 Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

Eisenberg, SP, Dripps, DJ, Brandhuber, BJ, Thompson, RC

J Biol Chem 1991
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