Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
RXRG [nucleoplasm]
Stable Identifier
R-HSA-446170
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Retinoic acid receptor RXR-gamma, RXRG_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Nuclear Receptor transcription pathway (Homo sapiens)
Formation of NR-MED1 Coactivator Complex (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
RXRG [nucleoplasm] (Homo sapiens)
NR-MED1 Coactivator Complex [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
RXRG [nucleoplasm] (Homo sapiens)
Formation of NR-NCOR Corepressor Complex (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
RXRG [nucleoplasm] (Homo sapiens)
NR-NCOR CoRepressor Complex [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
RXRG [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
Signaling by Retinoic Acid (Homo sapiens)
Acitretin binds to RAR:RXR (Homo sapiens)
RAR:RXR [nucleoplasm] (Homo sapiens)
RARG:RXRG [nucleoplasm] (Homo sapiens)
RXRG [nucleoplasm] (Homo sapiens)
RAR:RXR:acitretin [nucleoplasm] (Homo sapiens)
RAR:RXR [nucleoplasm] (Homo sapiens)
RARG:RXRG [nucleoplasm] (Homo sapiens)
RXRG [nucleoplasm] (Homo sapiens)
RAR:RXR binds SUMO-CRABP2:atRA (Homo sapiens)
RAR:RXR [nucleoplasm] (Homo sapiens)
RARG:RXRG [nucleoplasm] (Homo sapiens)
RXRG [nucleoplasm] (Homo sapiens)
SUMO-CRABP2:atRA:RAR:RXR [nucleoplasm] (Homo sapiens)
RAR:RXR [nucleoplasm] (Homo sapiens)
RARG:RXRG [nucleoplasm] (Homo sapiens)
RXRG [nucleoplasm] (Homo sapiens)
SUMO-CRABP2 dissociates from atRA:RAR:RXR (Homo sapiens)
SUMO-CRABP2:atRA:RAR:RXR [nucleoplasm] (Homo sapiens)
RAR:RXR [nucleoplasm] (Homo sapiens)
RARG:RXRG [nucleoplasm] (Homo sapiens)
RXRG [nucleoplasm] (Homo sapiens)
atRA:RAR:RXR [nucleoplasm] (Homo sapiens)
RAR:RXR [nucleoplasm] (Homo sapiens)
RARG:RXRG [nucleoplasm] (Homo sapiens)
RXRG [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48443 RXRG
Gene Names
RXRG, NR2B3
Chain
chain:1-463
Reference Genes
BioGPS Gene:6258 RXRG
COSMIC (genes):RXRG RXRG
CTD Gene:6258 RXRG
dbSNP Gene:6258 RXRG
ENSEMBL:ENSG00000143171 RXRG
HGNC:10479 RXRG
KEGG:hsa:6258 RXRG
Monarch:6258 RXRG
NCBI Gene:6258 RXRG
OMIM:180247 RXRG
UCSC:P48443 RXRG
Reference Transcript
RefSeq:NM_001256571.1 RXRG
RefSeq:NM_006917.4 RXRG
Other Identifiers
1048_at
1049_g_at
11727086_at
11733617_a_at
16695853
205954_PM_at
205954_at
2442009
2442010
2442011
2442016
2442017
2442018
2442019
2442020
2442021
2442022
2442023
2442025
2442026
2442029
2442030
2442033
2442034
6258
7921955
91433_at
A_23_P23292
A_33_P3308764
GE59123
GO:0000785
GO:0000981
GO:0003677
GO:0003700
GO:0003707
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0006355
GO:0006357
GO:0008270
GO:0030154
GO:0032526
GO:0043226
GO:0043401
GO:0043565
GO:0044323
GO:0045944
GO:0046872
GO:0048384
GO:0060089
GO:0060090
GO:0090575
GO:0140110
GO:0140693
GO:1990837
HMNXSV003045004
HMNXSV003046666
ILMN_1750624
ILMN_1809730
ILMN_2263333
PH_hs_0002342
TC01003464.hg
TC01005907.hg
U38480_at
g5902067_3p_at
g5902067_3p_x_at
p24767
Participates
as a component of
RARG:RXRG [nucleoplasm] (Homo sapiens)
as a member of
NR [nucleoplasm] (Homo sapiens)
Inferred To
Rxrg [nucleoplasm]
(Mus musculus)
Rxrg [nucleoplasm]
(Rattus norvegicus)
nhr-91 [nucleoplasm]
(Caenorhabditis elegans)
nhr-148 [nucleoplasm]
(Caenorhabditis elegans)
RXRG [nucleoplasm]
(Bos taurus)
RXRG [nucleoplasm]
(Canis familiaris)
RXRG [nucleoplasm]
(Gallus gallus)
RXRG [nucleoplasm]
(Sus scrofa)
nhr-207 [nucleoplasm]
(Caenorhabditis elegans)
nhr-209 [nucleoplasm]
(Caenorhabditis elegans)
nhr-60 [nucleoplasm]
(Caenorhabditis elegans)
nhr-221 [nucleoplasm]
(Caenorhabditis elegans)
nhr-154 [nucleoplasm]
(Caenorhabditis elegans)
rxrga [nucleoplasm]
(Danio rerio)
nhr-206 [nucleoplasm]
(Caenorhabditis elegans)
nhr-129 [nucleoplasm]
(Caenorhabditis elegans)
usp [nucleoplasm]
(Drosophila melanogaster)
nhr-120 [nucleoplasm]
(Caenorhabditis elegans)
nhr-137 [nucleoplasm]
(Caenorhabditis elegans)
nhr-141 [nucleoplasm]
(Caenorhabditis elegans)
nhr-116 [nucleoplasm]
(Caenorhabditis elegans)
nhr-204 [nucleoplasm]
(Caenorhabditis elegans)
nhr-208 [nucleoplasm]
(Caenorhabditis elegans)
nhr-149 [nucleoplasm]
(Caenorhabditis elegans)
rxrg [nucleoplasm]
(Xenopus tropicalis)
nhr-147 [nucleoplasm]
(Caenorhabditis elegans)
nhr-173 [nucleoplasm]
(Caenorhabditis elegans)
nhr-36 [nucleoplasm]
(Caenorhabditis elegans)
nhr-168 [nucleoplasm]
(Caenorhabditis elegans)
nhr-152 [nucleoplasm]
(Caenorhabditis elegans)
nhr-153 [nucleoplasm]
(Caenorhabditis elegans)
nhr-93 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of RXRG [nucleoplasm]
(Caenorhabditis elegans)
nhr-136 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
ZINC - World Drugs
RXRG_HUMAN
Guide to Pharmacology - Targets
612
ENSEMBL
ENST00000359842
,
ENSP00000352900
OpenTargets
ENSG00000143171
ZINC - FDA approved
RXRG_HUMAN
ZINC - Substances
RXRG_HUMAN
ZINC - Biogenic
RXRG_HUMAN
ZINC target
P48443
PRO
P48443
GlyGen
P48443
PDB
7A79
,
2GL8
ZINC - Investigational
RXRG_HUMAN
ZINC - Metabolites
RXRG_HUMAN
HPA
ENSG00000143171-RXRG
Pharos - Targets
P48443
ZINC - Predictions - Purchasable
RXRG_HUMAN
HMDB Protein
HMDBP01923
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10276 RARA
3
RARA [nucleoplasm]
(R-HSA-446164)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
0.944
18
UniProt:Q13133 NR1H3
1
NR1H3 [nucleoplasm]
(R-HSA-8854957)
0.742
7
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
18
UniProt:P19793 RXRA
4
RXRA [nucleoplasm]
(R-HSA-381319)
monoSUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
RXRA [cytosol]
(R-HSA-9619757)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
