Reactome | PPARG [nucleoplasm]

PPARG [nucleoplasm]

Stable Identifier

R-HSA-446172

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Peroxisome proliferator-activated receptor gamma, PPARG_HUMAN

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Regulation of lipid metabolism by PPARalpha (Homo sapiens)
    - PPARA activates gene expression (Homo sapiens)
      - Expression of ANGPTL4 (Homo sapiens)
        
        PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARG:Fatty Acid Ligand [nucleoplasm] (Homo sapiens)
        
        PPARG [nucleoplasm] (Homo sapiens)
      - Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
        
        PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
        
        Activated PPARG:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARG:Fatty Acid Ligand [nucleoplasm] (Homo sapiens)
        
        PPARG [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P37231 PPARG

Gene Names

PPARG, NR1C3

Chain

chain:1-505

Reference Genes

COSMIC (genes):PPARG PPARG

dbSNP Gene:5468 PPARG

ENSEMBL:ENSG00000132170 PPARG

Participates

as an input of

as an output of

as a component of

as a member of

NR [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K107,K395-PPARG [nucleoplasm]

Inferred To

Homologues of PPARG [nucleoplasm] (Caenorhabditis elegans)

nhr-2 [nucleoplasm] (Caenorhabditis elegans)

pparg [nucleoplasm] (Danio rerio)

rPparg [nucleoplasm] (Rattus norvegicus)

PPARG [nucleoplasm] (Bos taurus)

PPARG [nucleoplasm] (Canis familiaris)

PPARG [nucleoplasm] (Gallus gallus)

PPARG [nucleoplasm] (Sus scrofa)

Eip75B [nucleoplasm] (Drosophila melanogaster)

Pparg [nucleoplasm] (Mus musculus)

nhr-7 [nucleoplasm] (Caenorhabditis elegans)

nhr-85 [nucleoplasm] (Caenorhabditis elegans)

sex-1 [nucleoplasm] (Caenorhabditis elegans)

unc-55 [nucleoplasm] (Caenorhabditis elegans)

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	16
UniProt:P19793 RXRA	4	RXRA [nucleoplasm] (R-HSA-381319) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757)	0.64	3
UniProt:P28702 RXRB	1	RXRB [nucleoplasm] (R-HSA-446163)	0.632	5
UniProt:Q9UBK2 PPARGC1A	4	PPARGC1A [nucleoplasm] (R-HSA-442481) p-T178,S539-PPARGC1A [nucleoplasm] (R-HSA-1592204) p-T263,S266,T299-PPARGC1A [nucleoplasm] (R-HSA-1592224) monoSUMO1-K184-PPARGC1A [nucleoplasm] (R-HSA-3903023)	0.592	2
UniProt:O60869 EDF1			0.581	4
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.576	5
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.571	2
UniProt:Q8NFM4 ADCY4	1	ADCY4 [plasma membrane] (R-HSA-379054)	0.556	3
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.556	3
UniProt:Q9BWX5 GATA5	1	GATA5 [nucleoplasm] (R-HSA-996731)	0.556	3
UniProt:P45984 MAPK9	3	MAPK9 [cytosol] (R-HSA-450355) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q6STE5-2 SMARCD3			0.544	3
UniProt:Q6STE5-1 SMARCD3			0.544	3
UniProt:P10909 CLU	4	CLU(23-449) [extracellular region] (R-HSA-349732) CLU(23-449) [platelet alpha granule lumen] (R-HSA-349733) CLU(228-449) [extracellular region] (R-HSA-6810626) CLU(23-227) [extracellular region] (R-HSA-6810660)	0.524	3
IntAct:EBI-6267604 SIR1			0.499	2
UniProt:P37231 PPARG	2	monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444) PPARG [nucleoplasm] (R-HSA-446172)	0.499	2

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