Reactome | PPARG [nucleoplasm]

PPARG [nucleoplasm]

Stable Identifier

R-HSA-446172

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Peroxisome proliferator-activated receptor gamma, PPARG_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P10909 CLU

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External Reference Information

External Reference

UniProt:P37231 PPARG

Gene Names

PPARG, NR1C3

Chain

chain:1-505

Reference Genes

BioGPS Gene:5468 PPARG

COSMIC (genes):PPARG PPARG

CTD Gene:5468 PPARG

dbSNP Gene:5468 PPARG

ENSEMBL:ENSG00000132170 PPARG

HGNC:9236 PPARG

KEGG:hsa:5468 PPARG

Monarch:5468 PPARG

NCBI Gene:5468 PPARG

OMIM:601487 PPARG

UCSC:P37231 PPARG

Reference Transcript

Participates

as an input of

as an output of

as a component of

as a member of

NR [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K107,K395-PPARG [nucleoplasm]

Inferred To

Homologues of PPARG [nucleoplasm] (Caenorhabditis elegans)

nhr-2 [nucleoplasm] (Caenorhabditis elegans)

pparg [nucleoplasm] (Danio rerio)

rPparg [nucleoplasm] (Rattus norvegicus)

PPARG [nucleoplasm] (Bos taurus)

PPARG [nucleoplasm] (Canis familiaris)

PPARG [nucleoplasm] (Gallus gallus)

PPARG [nucleoplasm] (Sus scrofa)

Eip75B [nucleoplasm] (Drosophila melanogaster)

Pparg [nucleoplasm] (Mus musculus)

nhr-7 [nucleoplasm] (Caenorhabditis elegans)

nhr-85 [nucleoplasm] (Caenorhabditis elegans)

sex-1 [nucleoplasm] (Caenorhabditis elegans)

unc-55 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

XP_011532143.1, NP_005028.4, NP_056953.2, NP_619725.2, NP_619726.2

Guide to Pharmacology - Targets

595

OpenTargets

ENSG00000132170

ENSEMBL

ENSP00000287820, ENST00000287820, ENSG00000132170

ZINC - FDA approved

PPARG_HUMAN

ZINC - Substances

PPARG_HUMAN

ZINC - Biogenic

PPARG_HUMAN

ZINC target

P37231

PRO

P37231

GlyGen

P37231

PDB

3X1H, 3DZU, 3FUR, 5DSH, 8CPJ, 6C5T, 3SZ1, 7P4E, 6MD4, 3PRG, 3B0Q, 6ICJ, 8DSZ, 2I4J, 2ZNO, 3OSW, 8B92, 6Y3U, 6O68, 3VN2, 2VSR, 8B94, 8REJ, 4A4W, 3CS8, 2VV2, 3VJI, 8HUP, 1FM9, 4XUM, 3HO0, 5Z6S, 3ADV, 6T1S, 2ZK4, 8FKF, 1K74, 4PRG, 1NYX, 5HZC, 8PBO, 3H0A, 3ADS, 5JI0, 3B0R, 8BFF, 8ZFT, 3ET3, 7LOT, 5UGM, 4Y29, 6T6B, 2G0G, 2OM9, 7A7H, 7QB1, 3ET0, 7CXF, 8ZFR, 6VZL, 4E4K, 6DH9, 8HHP, 2VV3, 3E00, 8HUM, 4EMA, 3V9Y, 2I4Z, 2ZK5, 6T1V, 9F7X, 6K0T, 6AUG, 3ADW, 3OSI, 3WMH, 8FHF, 6C1I, 7AHJ, 8U57, 8ADF, 2XKW, 6ILQ, 8CPH, 3NOA, 2ZK0, 6E5A, 8BF2, 5GTO, 5YCP, 4R06, 8B93, 6O67, 2Q6S, 6ENQ, 3X1I, 4F9M, 7CXG, 1RDT, 6VZO, 1WM0, 8HHQ, 4FGY, 5YCN, 6FZJ, 3HOD, 7WGQ, 4E4Q, 5WQX, 2ZK6, 4R2U, 3S9S, 5TWO, 4CI5, 2P4Y, 2VST, 8FKG, 8FHG, 5LSG, 5Z5S, 2Q8S, 4JL4, 6D8X, 2ZK1, 5F9B, 3GBK, 7WGO, 6MD0, 5DV3, 8B91, 1PRG, 6DGL, 1I7I, 5GTN, 6IJS, 8AQN, 2Q6R, 6IZN, 8DKN, 7CXE, 7E0A, 6ONJ, 3VSP, 3R8A, 6VZN, 4R6S, 3IA6, 4OJ4, 6AD9, 7AWD, 2VV4, 6TSG, 6D94, 3ADX, 9F7W, 6JQ7, 3CDP, 3AN3, 5DWL, 4O8F, 8WFE, 3T03, 6JF0, 5DVC, 2GTK, 4L96, 3CDS, 2Q59, 1ZEO, 2ZVT, 2Q5S, 3WJ4, 2ATH, 3TY0, 7CXJ, 8DKV, 8ZFS, 6IZM, 8B8W, 5Y2O, 6ONI, 6PDZ, 3ADT, 6FZY, 6FZG, 7E2O, 3PO9, 2FVJ, 4HEE, 7AWC, 7WGP, 3V9T, 3LMP, 7SQA, 3AN4, 3VSO, 7CXL, 5AZV, 6DHA, 3QT0, 3FEJ, 5DV6, 3D6D, 2ZK2, 7RLE, 3R5N, 5DV8, 8DSY, 9CWN, 2POB, 3U9Q, 7CXK, 6DGR, 2F4B, 3B3K, 3V9V, 5Y2T, 3ADU, 8B8Z, 6L89, 8B95, 2Q5P, 5U5L, 8ATY, 8ZFP, 6QJ5, 6FZP, 6FZF, 6JEY, 6D3E, 6KTN, 3WJ5, 4XTA, 6DGP, 8BF1, 6TDC, 5WR1, 2HWR, 8FKC, 2HFP, 1KNU, 8FKE, 8CPI, 1FM6, 6C5Q, 4L98, 8ZFN, 5TTO, 6AN1, 6MCZ, 6MD2, 3DZY, 3K8S, 3BC5, 8B90, 2I4P, 2Q61, 6DGQ, 4PVU, 6F2L, 8ATZ, 7CXH, 8B8X, 8ZFQ, 6IJR, 3KMG, 6AVI, 8AQM, 6T9C, 6DCU, 6KTM, 5GTP, 2PRG, 4XUH, 4EM9, 8FKD, 5WR0, 2HWQ, 9CK0, 3B1M, 2VV0, 3PBA, 2YFE, 8ZFO, 7JQG, 6ZLY, 4PWL, 6MD1, 6DBH, 8SC9, 3VJH, 7CXI, 2G0H, 3G9E, 8DK4, 8C0C, 4JAZ, 2QMV, 6MS7, 8B8Y, 8FHE, 7SQB, 6VZM, 4YT1, 4A4V, 6DGO, 7EFQ, 3CWD, 2ZK3, 1ZGY, 6L8B, 7WOX, 3R8I, 2VV1, 4XLD

ZINC - Investigational

PPARG_HUMAN

ZINC - Metabolites

PPARG_HUMAN

HPA

ENSG00000132170-PPARG

GeneCards

PPARG

Pharos - Targets

P37231

Orphanet

PPARG

ZINC - Predictions - Purchasable

PPARG_HUMAN

HMDB Protein

HMDBP02173

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	16
UniProt:P19793 RXRA	4	RXRA [nucleoplasm] (R-HSA-381319) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757)	0.64	3
UniProt:P28702 RXRB	1	RXRB [nucleoplasm] (R-HSA-446163)	0.632	5
UniProt:Q9UBK2 PPARGC1A	4	PPARGC1A [nucleoplasm] (R-HSA-442481) p-T178,S539-PPARGC1A [nucleoplasm] (R-HSA-1592204) p-T263,S266,T299-PPARGC1A [nucleoplasm] (R-HSA-1592224) monoSUMO1-K184-PPARGC1A [nucleoplasm] (R-HSA-3903023)	0.592	2
UniProt:O60869 EDF1			0.581	4
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.576	5
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.571	2
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:P45984 MAPK9	3	p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) MAPK9 [cytosol] (R-HSA-450355)	0.556	3
UniProt:Q9BWX5 GATA5	1	GATA5 [nucleoplasm] (R-HSA-996731)	0.556	3
UniProt:Q8NFM4 ADCY4	1	ADCY4 [plasma membrane] (R-HSA-379054)	0.556	3
UniProt:Q6STE5-1 SMARCD3			0.544	3
UniProt:Q6STE5-2 SMARCD3			0.544	3
UniProt:P10909 CLU	4	CLU(23-449) [extracellular region] (R-HSA-349732) CLU(23-449) [platelet alpha granule lumen] (R-HSA-349733) CLU(228-449) [extracellular region] (R-HSA-6810626) CLU(23-227) [extracellular region] (R-HSA-6810660)	0.524	3
UniProt:P37231 PPARG	2	PPARG [nucleoplasm] (R-HSA-446172) monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444)	0.499	2
IntAct:EBI-6267604 SIR1			0.499	2

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