Reactome | Addition of a third glucose to the N-glycan precursor by an ALG10 homologue

Addition of a third glucose to the N-glycan precursor by an ALG10 homologue

Stable Identifier

R-HSA-446194

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

ReviewStatus

5/5

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Addition of a third glucose to the N-glycan precursor by an ALG10 homologue

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The last glucose is added to the N-glycan precursor. This reaction occurs inside the ER lumen and uses Dol-P-Glc as the glucose donor. In yeast, this reaction is catalyzed by ALG10 (Burda P and Aebi M,1998); however, this gene is duplicated in primates (Ciccarelli FD et al, 2005; Table 1), leading to two homologues, ALG10A and ALG10B, and to date there is no clear evidence to say which of these two paralogues (or both) is responsible for catalyzing this reaction in humans. No Congenital Disorders of Glycosylations are known to be associated with either gene.

Literature References

PubMed ID	Title	Journal	Year
9597543	The ALG10 locus of Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum: the terminal glucose of the lipid-linked oligosaccharide is required for efficient N-linked glycosylation Burda, P, Aebi, M	Glycobiology	1998
15710750	Complex genomic rearrangements lead to novel primate gene function von Mering, C, Ciccarelli, FD, Bork, P, Harrington, ED, Izaurralde, E, Suyama, M	Genome Res	2005

Participants

Input

Output

Participates

as an event of

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)

Catalyst Activity

dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity of ALG10 homologue [endoplasmic reticulum membrane]

Physical Entity

ALG10 homologue [endoplasmic reticulum membrane] (Homo sapiens)

Activity

dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity (GO:0004583)

Inferred From

Addition of a third glucose to the N-glycan skeleton by Alg10 (Saccharomyces cerevisiae)

Authored

Dall'Olio, GM (2009-11-10)

Reviewed

Gagneux, P (2010-04-16)

Created

Jassal, B (2009-11-10)

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