Reactome | IRAK1 [cytosol]

IRAK1 [cytosol]

Stable Identifier

R-HSA-446639

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Interleukin-1 receptor-associated kinase 1, IRAK1_HUMAN

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External Reference Information

External Reference

UniProt:P51617 IRAK1

Gene Names

IRAK1, IRAK

Chain

chain:1-712

Reference Genes

BioGPS Gene:3654 IRAK1

COSMIC (genes):IRAK1 IRAK1

CTD Gene:3654 IRAK1

dbSNP Gene:3654 IRAK1

ENSEMBL:ENSG00000184216 IRAK1

HGNC:6112 IRAK1

KEGG:hsa:3654 IRAK1

Monarch:3654 IRAK1

NCBI Gene:3654 IRAK1

OMIM:300283 IRAK1

UCSC:P51617 IRAK1

Reference Transcript

Participates

as an output of

IRAK1 gene expression is inhibited by MECP2 (Homo sapiens)

as an input of

IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)

as a component of

as a member of

IRAK1, IRAK2 [cytosol] (Homo sapiens)

Other forms of this molecule

p-2S,S376,T,T209,T387-IRAK1 [cytosol]

p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]

p-T209,T387-IRAK1 [plasma membrane]

p-T209-IRAK1 [plasma membrane]

IRAK1 [plasma membrane]

p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]

IRAK1 [endosome membrane]

p-T209,T387-IRAK1 [endosome membrane]

p-T209-IRAK1 [endosome membrane]

K63polyUb-hp-IRAK1 [cytosol]

p-S,T-IRAK1 [cytosol]

K63polyUb-hp-IRAK1 [endosome membrane]

p-S376,T387-IRAK1 [cytosol]

Inferred To

IRAK1 [cytosol] (Bos taurus)

IRAK1 [cytosol] (Canis familiaris)

IRAK1 [cytosol] (Mus musculus)

IRAK1 [cytosol] (Rattus norvegicus)

IRAK1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001020413.1, NP_001020414.1, NP_001560.2

Guide to Pharmacology - Targets

2042

OpenTargets

ENSG00000184216

ENSEMBL

ENST00000393687, ENSP00000358997, ENST00000369974, ENSP00000377291, ENSP00000358991, ENSG00000184216, ENST00000369980

ZINC - FDA approved

IRAK1_HUMAN

ZINC - Substances

IRAK1_HUMAN

ZINC - Biogenic

IRAK1_HUMAN

ZINC target

P51617

PRO

P51617

GlyGen

P51617

PDB

6BFN

ZINC - Investigational

IRAK1_HUMAN

GeneCards

IRAK1

HPA

ENSG00000184216-IRAK1

Pharos - Targets

P51617

Orphanet

IRAK1

ZINC - Predictions - Purchasable

IRAK1_HUMAN

HMDB Protein

HMDBP08733

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.77	4
UniProt:Q9HAT8 PELI2	2	PELI2 [cytosol] (R-HSA-450694) p-PELI2 [cytosol] (R-HSA-450825)	0.743	4
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.734	4
UniProt:Q99836 MYD88	8	MYD88 [cytosol] (R-HSA-166059) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [endosome membrane] (R-HSA-975123) MyD88 E65del [cytosol] (R-HSA-5602598) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 R196C [cytosol] (R-HSA-5602329)	0.723	4
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.645	10
UniProt:P58753 TIRAP	2	p-4Y-TIRAP [plasma membrane] (R-HSA-2201321) TIRAP [cytosol] (R-HSA-166141)	0.623	3
UniProt:Q8N2H9-2 PELI3			0.589	2
UniProt:O43187 IRAK2	6	IRAK2 [endosome membrane] (R-HSA-975116) p-IRAK2 [endosome membrane] (R-HSA-975187) IRAK2 [plasma membrane] (R-HSA-937014) IRAK2 [cytosol] (R-HSA-772534) p-IRAK2 [plasma membrane] (R-HSA-936949) p-IRAK2 [cytosol] (R-HSA-446636)	0.564	3
UniProt:Q9Y616 IRAK3	1	IRAK3 [cytosol] (R-HSA-166103)	0.564	3
UniProt:Q9NWZ3 IRAK4	9	IRAK4 [cytosol] (R-HSA-166081) p-T342,T345,S346-IRAK4 [plasma membrane] (R-HSA-936957) IRAK4 [plasma membrane] (R-HSA-937051) p-T342,T345,S346-IRAK4 [endosome membrane] (R-HSA-975149) IRAK4 [endosome membrane] (R-HSA-975167) p-T342,T345,S346-IRAK4 [cytosol] (R-HSA-446649) IRAK4 E402* [cytosol] (R-HSA-5602517) IRAK4 R12C [cytosol] (R-HSA-5602511) IRAK4 Q293* [cytosol] (R-HSA-5602426)	0.547	2
UniProt:Q5D1E7	1	ZC3H12A [nucleoplasm] (R-MMU-9774235)	0.544	3
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.527	2
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.527	2
UniProt:P31689 DNAJA1	2	SOH-C149,C150-DNAJA1 [cytosol] (R-HSA-9857072) DNAJA1 [cytosol] (R-HSA-3371544)	0.527	2
UniProt:Q96EY1 DNJA3			0.527	2
UniProt:O60884 DNAJA2	1	DNAJA2 [cytosol] (R-HSA-3371555)	0.527	2
UniProt:O15027 SEC16A	1	SEC16A [cytosol] (R-HSA-5685728)	0.527	2
UniProt:Q92985 IRF7	5	IRF7 [cytosol] (R-HSA-450281) p-S477,S479-IRF7 [cytosol] (R-HSA-450318) p-S477,S479-IRF7 [nucleoplasm] (R-HSA-450270) IRF7 [endosome membrane] (R-HSA-450274) K63polyUb-IRF7 [endosome membrane] (R-HSA-975154)	0.499	2
UniProt:Q15306 IRF4	2	IRF4 [nucleoplasm] (R-HSA-9907101) IRF4 [cytosol] (R-HSA-1015679)	0.499	2
UniProt:Q8VCW4	2	Unc93b1 [endoplasmic reticulum membrane] (R-MMU-1678930) Unc93b1 [Golgi membrane] (R-MMU-1679064)	0.499	2
UniProt:Q86WV6 STING1	5	STING [endoplasmic reticulum membrane] (R-HSA-1834940) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) TMEM173 [secretory granule membrane] (R-HSA-6804798) TMEM173 [plasma membrane] (R-HSA-6804815)	0.499	2

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