The Interleukin 1 receptor complex binds Tollip

Stable Identifier
R-HSA-446868
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Toll-interacting protein (TOLLIP) binds to IRAK1 and IL-1RAP within the receptor complex. TOLLIP has the capacity to act as an ubiquitin-binding receptor for ubiquitinated IL1R1, linking IL1R to endosomal degradation.
Literature References
PubMed ID Title Journal Year
10854325 Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

Maschera, B, Volpe, F, Plumpton, C, Martinon, F, Ray, KP, Burns, K, Tschopp, J, Lewis, A, Martin, L, Clatworthy, J

Nat Cell Biol 2000
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Orthologous Events
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