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TOLLIP [cytosol]
Stable Identifier
R-HSA-446885
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Toll-interacting protein, TOLIP_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q4VC12 MSS51
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)
TOLLIP [cytosol] (Homo sapiens)
The Interleukin 1 receptor complex binds Tollip (Homo sapiens)
TOLLIP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H0E2 TOLLIP
Gene Names
TOLLIP
Chain
initiator methionine:, chain:2-274
Reference Genes
BioGPS Gene:54472 TOLLIP
COSMIC (genes):TOLLIP TOLLIP
CTD Gene:54472 TOLLIP
dbSNP Gene:54472 TOLLIP
ENSEMBL:ENSG00000078902 TOLLIP
HGNC:16476 TOLLIP
KEGG:hsa:54472 TOLLIP
Monarch:54472 TOLLIP
NCBI Gene:54472 TOLLIP
OMIM:606277 TOLLIP
UCSC:Q9H0E2 TOLLIP
Reference Transcript
RefSeq:NM_001318514.1 TOLLIP
RefSeq:NM_001318515.1 TOLLIP
RefSeq:NM_001318512.1 TOLLIP
RefSeq:NM_019009.3 TOLLIP
RefSeq:NM_001318516.1 TOLLIP
Other Identifiers
11722171_a_at
11722172_a_at
11755301_a_at
16734240
217930_PM_s_at
217930_s_at
222469_PM_s_at
222469_s_at
233881_PM_s_at
233881_s_at
237342_PM_at
237342_at
3358740
3358741
3358743
3358744
3358745
3358746
3358747
3358748
3358752
3358754
3358755
3358756
3358757
3358759
3358760
3358761
3358763
3358764
3358767
3358768
3358769
3358771
45728_at
54472
61979_i_at
61980_r_at
7945620
91328_at
A_23_P75903
A_24_P287189
A_33_P3385101
GE55270
GE846858
GO:0002376
GO:0005150
GO:0005515
GO:0005576
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0006511
GO:0006914
GO:0006954
GO:0007165
GO:0016310
GO:0016604
GO:0019897
GO:0019900
GO:0030154
GO:0030855
GO:0031410
GO:0031624
GO:0031625
GO:0032183
GO:0032991
GO:0033235
GO:0035325
GO:0035578
GO:0035580
GO:0036010
GO:0043130
GO:0043226
GO:0045087
GO:0045321
GO:0048471
GO:0060090
GO:0070062
GO:0070498
GO:0098542
HMNXSV003058436
Hs.146565.0.A1_3p_at
Hs.25413.1.S1_3p_a_at
ILMN_1765523
PH_hs_0002235
TC11001258.hg
g12053176_3p_a_at
g9506854_3p_a_at
Participates
as an output of
TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)
as an input of
The Interleukin 1 receptor complex binds Tollip (Homo sapiens)
as a component of
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
Other forms of this molecule
TOLLIP [specific granule lumen]
TOLLIP [extracellular region]
TOLLIP [azurophil granule lumen]
Inferred To
tollip [cytosol]
(Xenopus tropicalis)
Tollip [cytosol]
(Mus musculus)
Tollip [cytosol]
(Rattus norvegicus)
TOLLIP [cytosol]
(Bos taurus)
TOLLIP [cytosol]
(Canis familiaris)
TOLLIP [cytosol]
(Gallus gallus)
TOLLIP [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001305445.1
,
NP_001305443.1
,
NP_001305441.1
,
NP_061882.2
,
NP_001305444.1
OpenTargets
ENSG00000078902
ENSEMBL
ENST00000707519
,
ENSP00000314733
,
ENSP00000516890
,
ENSP00000434035
,
ENST00000317204
,
ENSP00000516891
,
ENST00000707520
,
ENST00000527886
HPA
ENSG00000078902-TOLLIP
PRO
Q9H0E2
Pharos - Targets
Q9H0E2
GlyGen
Q9H0E2
PDB
1WGL
,
2N31
Interactors (56)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60784 TOM1
3
TOM1 [specific granule membrane]
(R-HSA-6800923)
TOM1 [plasma membrane]
(R-HSA-6806274)
TOM1 [azurophil granule membrane]
(R-HSA-6799348)
0.851
8
UniProt:Q15038 DAZP2
0.841
11
UniProt:O75674 TM1L1
0.804
6
UniProt:Q9BQY4 RHXF2
0.8
6
UniProt:Q05048 CSTF1
1
CSTF1 [nucleoplasm]
(R-HSA-72001)
0.695
5
UniProt:P54253 ATX1
0.666
7
UniProt:Q96HA8 NTAQ1
0.666
4
UniProt:Q93062 RBPMS
0.666
4
UniProt:Q6ZVM7 TM1L2
0.659
4
UniProt:Q3LI66 KRTAP6-2
1
KRTAP6-2 [cytosol]
(R-HSA-6810261)
0.556
5
UniProt:Q4VC12 MSS51
0.556
3
UniProt:Q6ZVM7-2 TOM1L2
0.556
7
UniProt:Q3LI64 KRTAP6-1
1
KRTAP6-1 [cytosol]
(R-HSA-6810298)
0.556
5
UniProt:Q86UA1 PRP39
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:P35609 ACTN2
3
ACTN2 [cytosol]
(R-HSA-390562)
ACTN2 [platelet alpha granule lumen]
(R-HSA-349727)
ACTN2 [extracellular region]
(R-HSA-349725)
0.556
3
UniProt:Q70EL1-9 USP54
0.556
3
UniProt:Q9H668 STN1
1
STN1 [nucleoplasm]
(R-HSA-9668821)
0.556
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:Q9UHG0 DCDC2
0.556
3
IntAct:EBI-22404606 CCSB ORF ID
0.556
3
UniProt:Q9H305 CDIP1
0.556
3
UniProt:Q3SY46 KRTAP13-3
1
KRTAP13-3 [cytosol]
(R-HSA-6810267)
0.556
5
UniProt:Q5VYS4 MEDAG
0.556
3
UniProt:A8MTA8-2 CIMIP2B
0.556
3
UniProt:Q14764 MVP
3
MVP [ficolin-1-rich granule lumen]
(R-HSA-6803325)
MVP [extracellular region]
(R-HSA-6806474)
MVP [secretory granule lumen]
(R-HSA-6803290)
0.556
3
UniProt:Q96B67 ARRD3
0.556
3
UniProt:O60260-5 PRKN
0.556
3
UniProt:Q5BKX5-3 ACTMAP
0.556
3
UniProt:O75553 DAB1
2
DAB1 [cytosol]
(R-HSA-8855236)
p-Y198,220,232-DAB1 [cytosol]
(R-HSA-8855227)
0.556
3
UniProt:O75674-2 TOM1L1
0.556
5
UniProt:Q9BSU1 PHAF1
0.556
5
UniProt:P35548 MSX2
1
MSX2 [nucleoplasm]
(R-HSA-9007760)
0.556
3
UniProt:Q8IUC3 KRA71
0.556
3
UniProt:Q16656-4 NRF1
0.556
3
UniProt:Q14203-5 DCTN1
0.556
3
UniProt:O60784-2 TOM1
0.556
5
UniProt:Q92567-2 FAM168A
0.556
3
UniProt:Q96E35 ZMY19
0.556
3
UniProt:Q8N5M4 TTC9C
0.556
3
UniProt:P32502
1
GCD7 [cytosol]
(R-SCE-72519)
0.556
3
UniProt:P86480 PR20D
0.556
3
UniProt:Q3LI76 KRTAP15-1
1
KRTAP15-1 [cytosol]
(R-HSA-6810304)
0.556
3
UniProt:Q96NT3-2 GUCD1
0.556
3
UniProt:P20618 PSMB1
7
PSMB1 [cytosol]
(R-HSA-68738)
PSMB1 [nucleoplasm]
(R-HSA-174347)
PSMB1 [secretory granule lumen]
(R-HSA-6803287)
PSMB1 [extracellular region]
(R-HSA-6806477)
PSMB1 [ficolin-1-rich granule lumen]
(R-HSA-6803340)
pro-PSMB1 [cytosol]
(R-HSA-9908139)
PSMB1(1-28) [cytosol]
(R-HSA-9908143)
0.556
3
UniProt:Q3SYF9 KRTAP19-7
1
KRTAP19-7 [cytosol]
(R-HSA-6810305)
0.556
3
UniProt:Q9NWB1-5 RBFOX1
0.556
3
UniProt:A1E959 ODAM
1
ODAM [extracellular region]
(R-HSA-977149)
0.553
2
UniProt:Q96S55 WRIP1
0.499
2
UniProt:Q86TG7 PEG10
0.499
2
UniProt:Q86Y13 DZIP3
1
DZIP3 [cytosol]
(R-HSA-976002)
0.499
2
UniProt:P19525 EIF2AK2
5
EIF2AK2 [cytosol]
(R-HSA-168699)
p-EIF2AK2 [nucleoplasm]
(R-HSA-9836332)
p-EIF2AK2 [cytosol]
(R-HSA-9833834)
ISG15-EIF2AK2 [cytosol]
(R-HSA-9833968)
SUMO-EIF2AK2 [cytosol]
(R-HSA-9834829)
0.499
2
UniProt:O43187 IRAK2
6
IRAK2 [endosome membrane]
(R-HSA-975116)
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.499
2
UniProt:Q9H492 MAP1LC3A
3
MAP1LC3A [cytosol]
(R-HSA-5205676)
MAP1LC3A(1-121) [cytosol]
(R-HSA-5682681)
MAP1LC3A [autophagosome membrane]
(R-HSA-5683640)
0.463
3
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