Reactome | IL11 [extracellular region]

IL11 [extracellular region]

Stable Identifier

R-HSA-447097

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Interleukin-11, IL11_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P25815 S100P

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-6 family signaling (Homo sapiens)
      - IL-6-type cytokine receptor ligand interactions (Homo sapiens)
        
        IL11 binds IL11RA (Homo sapiens)
        
        IL11 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P20809 IL11

Gene Names

IL11

Chain

signal peptide:1-21, chain:22-199

Reference Genes

BioGPS Gene:3589 IL11

COSMIC (genes):IL11 IL11

CTD Gene:3589 IL11

dbSNP Gene:3589 IL11

ENSEMBL:ENSG00000095752 IL11

HGNC:5966 IL11

KEGG:hsa:3589 IL11

Monarch:3589 IL11

NCBI Gene:3589 IL11

OMIM:147681 IL11

UCSC:P20809 IL11

Reference Transcript

Other Identifiers

11727690_at

11727691_a_at

11751797_a_at

16875754

206924_PM_at

206924_at

206926_PM_s_at

206926_s_at

35464_at

3589

3871400

3871401

3871402

3871403

3871404

3871405

3871407

3871408

3871409

3871410

3871413

3871414

3871415

3871416

3871417

8039484

A_23_P67169

A_33_P3243887

GE80144

GO:0002376

GO:0005125

GO:0005142

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0006355

GO:0007165

GO:0008083

GO:0008283

GO:0008284

GO:0030154

GO:0030183

GO:0030219

GO:0033138

GO:0038154

GO:0043410

GO:0045444

GO:0045944

GO:0046888

GO:0048018

GO:0050731

GO:0098772

HMNXSV003044199

ILMN_1788107

PH_hs_0000234

TC19001870.hg

X58377_at

g10834993_3p_at

g186272_3p_a_at

Participates

as a component of

IL11RA:IL11 [plasma membrane] (Homo sapiens)

as an input of

IL11 binds IL11RA (Homo sapiens)

Inferred To

IL11 [extracellular region] (Canis familiaris)

IL11 [extracellular region] (Gallus gallus)

IL11 [extracellular region] (Sus scrofa)

il11 [extracellular region] (Xenopus tropicalis)

Il11 [extracellular region] (Mus musculus)

Il11 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_000632.1, NP_001254647.1

ENSEMBL

ENST00000264563, ENSP00000467355, ENST00000585513, ENSP00000264563, ENST00000590625, ENSP00000465705

OpenTargets

ENSG00000095752

HPA

ENSG00000095752-IL11

PRO

P20809

Pharos - Targets

P20809

PDB

6O4O, 8DPV, 8DPT, 8DPU, 8DPW, 8DPS, 4MHL, 8QY4

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43364 MAGAB			0.666	4
UniProt:P25815 S100P	2	S100P [extracellular region] (R-HSA-6804809) S100P [secretory granule lumen] (R-HSA-6804782)	0.558	2
calcium(2+) [ChEBI:29108]	20	Ca2+ [platelet dense granule lumen] (R-ALL-114582) Ca2+ [endosome membrane] (R-ALL-5210949) Ca2+ [sarcoplasmic reticulum lumen] (R-ALL-2855229) Ca2+ [mitochondrial intermembrane space] (R-ALL-8949232) Ca2+ [lysosomal lumen] (R-ALL-1606834) Ca2+ [endocytic vesicle lumen] (R-ALL-8851519) Ca2+ [endoplasmic reticulum-Golgi intermediate compartment] (R-ALL-9706979) Ca2+ [Golgi lumen] (R-ALL-167012) Ca2+ [platelet dense tubular network lumen] (R-ALL-139827) Ca2+ [platelet dense tubular network membrane] (R-ALL-141090) Ca2+ [plasma membrane] (R-ALL-140648) Ca2+ [secretory granule lumen] (R-ALL-216801) Ca2+ [nuclear envelope] (R-ALL-2318767) Ca2+ [nucleoplasm] (R-ALL-29496) Ca2+ [mitochondrial matrix] (R-ALL-8949220) Ca2+ [mitochondrial inner membrane] (R-ALL-1524102) Ca2+ [endoplasmic reticulum membrane] (R-ALL-1500625) Ca2+ [cytosol] (R-ALL-74016) Ca2+ [extracellular region] (R-ALL-74112) Ca2+ [endoplasmic reticulum lumen] (R-ALL-111875)	0.558	2
UniProt:P43364-2 MAGEA11			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3

Cite Us!