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IL23R [plasma membrane]
Stable Identifier
R-HSA-447156
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin-23 receptor component, IL23R_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9NPF7 IL23A
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-23 signaling (Homo sapiens)
IL23R binds JAK2 (Homo sapiens)
IL23R [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5VWK5 IL23R
Gene Names
IL23R
Chain
signal peptide:1-23, chain:24-629
Reference Genes
BioGPS Gene:149233 IL23R
COSMIC (genes):IL23R IL23R
CTD Gene:149233 IL23R
dbSNP Gene:149233 IL23R
ENSEMBL:ENSG00000162594 IL23R
ENSEMBL_homo_sapiens_GENE:ENSG00000162594.17 IL23R
HGNC:19100 IL23R
KEGG Gene (Homo sapiens):149233 IL23R
Monarch:149233 IL23R
NCBI Gene:149233 IL23R
OMIM:607562 IL23R
UCSC:Q5VWK5 IL23R
Reference Transcript
RefSeq:XM_005270516.2 IL23R
RefSeq:XM_011540790.2 IL23R
RefSeq:XM_011540791.2 IL23R
RefSeq:NM_144701.2 IL23R
Other Identifiers
11737362_x_at
11748794_a_at
149233
1552912_3p_a_at
1552912_PM_a_at
1552912_a_at
1561853_PM_a_at
1561853_a_at
16665878
2340933
2340934
2340935
2340936
2340939
2340941
2340943
2340944
2340947
2340948
2340951
2340952
2340953
2340954
2340955
2340956
2340957
2340958
7902189
A_14_P135991
A_23_P425197
GO:0001916
GO:0002230
GO:0002376
GO:0002827
GO:0004896
GO:0005143
GO:0005515
GO:0005886
GO:0006954
GO:0007155
GO:0009897
GO:0010536
GO:0016020
GO:0019221
GO:0019955
GO:0023052
GO:0030154
GO:0032496
GO:0032693
GO:0032725
GO:0032729
GO:0032735
GO:0032740
GO:0032819
GO:0034341
GO:0036211
GO:0038155
GO:0042019
GO:0042020
GO:0042102
GO:0042104
GO:0042509
GO:0042531
GO:0043235
GO:0043382
GO:0045087
GO:0045672
GO:0048856
GO:0050829
GO:0051135
GO:0060089
GO:0072536
GO:0098542
GO:2000318
GO:2000330
HMNXSV003000736
Hs2.375184.3.S1_3p_a_at
ILMN_1734937
ILMN_2223663
PH_hs_0018226
TC01000739.hg
TC01004453.hg
Participates
as an input of
IL23R binds JAK2 (Homo sapiens)
as a component of
IL23R:JAK2 [plasma membrane] (Homo sapiens)
IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
as a member of
STAT3-upregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y-IL23R [plasma membrane]
Inferred To
IL23R [plasma membrane]
(Bos taurus)
IL23R [plasma membrane]
(Canis familiaris)
IL23R [plasma membrane]
(Sus scrofa)
Il23r [plasma membrane]
(Mus musculus)
Il23r [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_011539092.1
,
XP_005270573.1
,
XP_011539093.1
,
NP_653302.2
Guide to Pharmacology - Targets
1717
OpenTargets
ENSG00000162594
GeneCards
Q5VWK5
HPA
ENSG00000162594-IL23R
Ensembl
ENSG00000162594
,
ENSP00000513140
,
ENST00000697223
,
ENSP00000513191
,
ENST00000425614
,
ENST00000697153
,
ENSP00000513190
,
ENST00000697149
,
ENST00000697224
,
ENST00000347310
,
ENSP00000321345
,
ENSP00000513139
,
ENSP00000513138
,
ENST00000697150
,
ENSP00000387640
,
ENST00000697151
,
ENSP00000513142
PRO
Q5VWK5
Pharos - Targets
Q5VWK5
Orphanet
16256
PDB
6WDQ
,
8OE4
,
5MZV
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-9992716 INTERLEUKIN-23
0.558
2
UniProt:Q13901 C1D
1
C1D [nucleoplasm]
(R-HSA-6791515)
0.556
3
UniProt:Q9NPF7 IL23A
2
IL23A [endoplasmic reticulum lumen]
(R-HSA-8950224)
IL23A [extracellular region]
(R-HSA-447245)
0.525
2
UniProt:Q62120 Jak2
11
phospho-p-Y1007,Y1008-JAK2 [cytosol]
(R-MMU-9005327)
p-Jak2 [cytosol]
(R-MMU-8950633)
phospho-p-JAK2 [cytosol]
(R-MMU-210621)
phospho-p-Y813-JAK2 [cytosol]
(R-MMU-997248)
JAK2 [endosome lumen]
(R-MMU-2002372)
JAK2 [cytosol]
(R-MMU-210620)
phospho-p-Y1007-JAK2 [cytosol]
(R-MMU-873799)
Jak2 [cytosol]
(R-MMU-205743)
phospho-p-12Y-JAK2 [cytosol]
(R-MMU-2586516)
p-Y1007-Jak2 [cytosol]
(R-MMU-997296)
p-12Y-Jak2 [cytosol]
(R-MMU-2586515)
0.499
2
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