Reactome | IL12B [extracellular region]

IL12B [extracellular region]

Stable Identifier

R-HSA-447181

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

IL12p40, Interleukin-12 subunit beta, IL12B_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P29460 IL12B

Gene Names

IL12B, NKSF2

Chain

signal peptide:1-22, chain:23-328

Reference Genes

BioGPS Gene:3593 IL12B

COSMIC (genes):IL12B IL12B

CTD Gene:3593 IL12B

dbSNP Gene:3593 IL12B

ENSEMBL:ENSG00000113302 IL12B

ENSEMBL_homo_sapiens_GENE:ENSG00000113302.6 IL12B

HGNC:5970 IL12B

KEGG Gene (Homo sapiens):3593 IL12B

Monarch:3593 IL12B

NCBI Gene:3593 IL12B

OMIM:161561 IL12B

UCSC:P29460 IL12B

Reference Transcript

RefSeq:NM_002187.2 IL12B

Other Identifiers

11737833_at

11737834_at

17002328

207901_PM_at

207901_at

2884302

2884303

2884305

2884306

2884307

2884308

2884310

2884311

2884312

2884313

2884316

3593

563_at

8115570

A_23_P7560

GE58044

GO:0001817

GO:0001916

GO:0002230

GO:0002323

GO:0002376

GO:0002827

GO:0002860

GO:0002862

GO:0004896

GO:0005125

GO:0005126

GO:0005143

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005768

GO:0005783

GO:0005788

GO:0005829

GO:0005886

GO:0006954

GO:0007155

GO:0007166

GO:0008083

GO:0008283

GO:0009897

GO:0009986

GO:0010033

GO:0010224

GO:0010536

GO:0012501

GO:0016020

GO:0016477

GO:0019221

GO:0019953

GO:0019955

GO:0023052

GO:0030101

GO:0030154

GO:0031410

GO:0031906

GO:0032693

GO:0032700

GO:0032725

GO:0032729

GO:0032733

GO:0032735

GO:0032740

GO:0032760

GO:0032816

GO:0032819

GO:0032946

GO:0034105

GO:0034393

GO:0035722

GO:0036211

GO:0042088

GO:0042093

GO:0042098

GO:0042102

GO:0042104

GO:0042164

GO:0042509

GO:0042531

GO:0042802

GO:0042832

GO:0043226

GO:0043235

GO:0043382

GO:0043514

GO:0044877

GO:0045519

GO:0045672

GO:0045785

GO:0046982

GO:0048018

GO:0048662

GO:0048856

GO:0048870

GO:0050671

GO:0050709

GO:0050729

GO:0050829

GO:0051135

GO:0051142

GO:0051607

GO:0060089

GO:0070743

GO:0071222

GO:0071346

GO:0098542

GO:0098772

GO:1900747

GO:1901224

GO:1903588

GO:2000318

GO:2000330

HMNXSV003009674

ILMN_1681132

M65290_at

PH_hs_0000077

TC05001997.hg

g4504640_3p_at

Participates

as a component of

as an output of

IL12B translocates from the cytosol to the extracellular region (Homo sapiens)

as a member of

IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)

This entity regulates

Negatively

Interleukin-12 binds Interleukin-12 receptor (Homo sapiens)

Other forms of this molecule

IL12B [endoplasmic reticulum lumen]

IL12B [late endosome lumen]

IL12B [Golgi lumen]

IL12B [cytosol]

Inferred To

il12ba [extracellular region] (Danio rerio)

IL12B [extracellular region] (Bos taurus)

IL12B [extracellular region] (Canis familiaris)

IL12B [extracellular region] (Sus scrofa)

il12b [extracellular region] (Xenopus tropicalis)

IL-12B [extracellular region] (Gallus gallus)

Il12b [extracellular region] (Mus musculus)

Il12b [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_002178.2

OpenTargets

ENSG00000113302

GeneCards

P29460

HPA

ENSG00000113302-IL12B

Ensembl

ENSG00000113302, ENST00000231228, ENSP00000231228

PRO

P29460

Pharos - Targets

P29460

Orphanet

16254

PDB

5MJ3, 1F42, 6UIB, 4GRW, 3D87, 8OE4, 6WDQ, 3HMX, 3QWR, 8CR8, 5MXA, 5NJD, 3D85, 3DUH, 1F45, 5MJ4, 5MZV

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NPF7 IL23A	2	IL23A [endoplasmic reticulum lumen] (R-HSA-8950224) IL23A [extracellular region] (R-HSA-447245)	0.813	6
UniProt:P29459 IL12A	4	IL12A [Golgi lumen] (R-HSA-8950463) IL12A [endoplasmic reticulum lumen] (R-HSA-8950139) IL12A [late endosome lumen] (R-HSA-8950449) IL12A [extracellular region] (R-HSA-447212)	0.609	2
UniProt:P29460 IL12B	5	IL12B [extracellular region] (R-HSA-447181) IL12B [endoplasmic reticulum lumen] (R-HSA-8950126) IL12B [late endosome lumen] (R-HSA-8950675) IL12B [Golgi lumen] (R-HSA-8950359) IL12B [cytosol] (R-HSA-8950760)	0.524	2
UniProt:Q9EQ14 Il23a	3	Il23a [endoplasmic reticulum lumen] (R-MMU-8950224) Il23a [extracellular region] (R-MMU-8950470) Il23a [extracellular region] (R-MMU-447245)	0.524	2

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