Reactome | IL34 dimerizes

IL34 dimerizes

Stable Identifier

R-HSA-448632

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Interleukin-34 is a homodimer

ReviewStatus

5/5

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interleukin-34 (IL34) was identified as a potent activator of monocytes and macrophages, signaling through Colony-stimulating factor-1 (CSF1) receptor (CSF1R) with a distinct tissue distribution from CSF1 (Lin et al. 2008). IL34 and CSF1 share many functional properties. IL34 has no appreciable sequence similarity with any other protein but shares a four-helix bundle structure seen in CSF1 (Garceau et al. 2010, Liu et al. 2012). IL34 forms a noncovalently linked dimer (Ma et al. 2012) whereas CSF1 contains an intersubunit disulfide bond. The structure of the IL34:CSF1R complex shows a similar ligand-receptor assembly to that of CSF1:CSF1R.

Literature References

PubMed ID	Title	Journal	Year
18467591	Discovery of a cytokine and its receptor by functional screening of the extracellular proteome Leo, C, Halenbeck, R, Linnemann, T, Doberstein, SK, Lin, H, Williams, LT, Qin, M, Wong, J, Wu, G, Behrens, D, Huang, M, Hollenbaugh, D, Hestir, K, Chu, K, Lee, E, Zhou, A, Bosch, E	Science	2008