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IL34 [extracellular region]
Stable Identifier
R-HSA-448636
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-34, IL34_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
CSF1 dimer binds CSF1R or IL34 (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:CSF1R [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer binds SRC family kinases FYN,HCK,SRC,YES1 (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds CBL (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1 (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1 (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1R dimerizes (Homo sapiens)
CSF1 dimer,IL34 dimer:CSF1R [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1R trans-autophosphorylates on multiple tyrosine and serine residues (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb-p-Y561-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb-p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1R trans-autophosphorylates on tyrosine-561 (Homo sapiens)
CSF1 dimer,IL34 dimer:CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb-p-Y561-CSF1R dimer:SFK:PolyUb,p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb-p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:p-Y-CBL [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK [plasma membrane] (Homo sapiens)
CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer [plasma membrane] (Homo sapiens)
CSF1 dimer, IL34 dimer [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Other interleukin signaling (Homo sapiens)
IL34 binds CSF1 (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
IL34:CSF1 [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
IL34 dimer binds CSF1R (Homo sapiens)
CSF1R:IL34 dimer [plasma membrane] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
IL34 dimer binds PTPRZ1 (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
IL34 dimer:PTPRZ1 [plasma membrane] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
IL34 dimer binds SDC1 (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
IL34 dimer:SDC1 [plasma membrane] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
IL34 dimer:SDC1 binds CSF1R (Homo sapiens)
IL34 dimer:SDC1 [plasma membrane] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
IL34 dimer:SDC1:CSF1R [plasma membrane] (Homo sapiens)
IL34 dimer:SDC1 [plasma membrane] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
IL34 dimerizes (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
IL34:CSF1 binds CSF1R (Homo sapiens)
IL34:CSF1 [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
IL34:CSF1:CSF1R [plasma membrane] (Homo sapiens)
IL34:CSF1 [extracellular region] (Homo sapiens)
IL34 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6ZMJ4 IL34
Gene Names
IL34, C16orf77
Chain
signal peptide:1-20, chain:21-242
Reference Genes
BioGPS Gene:146433 IL34
COSMIC (genes):IL34 IL34
CTD Gene:146433 IL34
dbSNP Gene:146433 IL34
ENSEMBL:ENSG00000157368 IL34
ENSEMBL_homo_sapiens_GENE:ENSG00000157368.12 IL34
HGNC:28529 IL34
KEGG Gene (Homo sapiens):146433 IL34
Monarch:146433 IL34
NCBI Gene:146433 IL34
OMIM:612081 IL34
UCSC:Q6ZMJ4 IL34
Reference Transcript
RefSeq:NM_001172772.1 IL34
RefSeq:XM_011522902.2 IL34
RefSeq:NM_152456.2 IL34
RefSeq:XM_011522903.2 IL34
RefSeq:NM_001172771.1 IL34
Other Identifiers
11726706_at
11726707_x_at
146433
16820822
237046_3p_x_at
237046_PM_x_at
237046_x_at
3667333
3667343
3667344
3667345
3667346
3667348
3667349
3667351
3667352
3667354
3667355
3667356
3667357
3667358
3667359
7997128
82033_at
A_23_P100386
GE482235
GO:0001934
GO:0002376
GO:0005125
GO:0005157
GO:0005515
GO:0005576
GO:0005615
GO:0006954
GO:0008083
GO:0008284
GO:0010628
GO:0010759
GO:0023052
GO:0030154
GO:0036211
GO:0042802
GO:0043406
GO:0045087
GO:0045651
GO:0045657
GO:0048018
GO:0048714
GO:0048856
GO:0048870
GO:0061098
GO:0061514
GO:0061518
GO:0098542
GO:0098772
GO:0120041
HMNXSV003052508
Hs.128514.0.A1_3p_at
Hs.128514.0.A1_3p_x_at
ILMN_1713686
PH_hs_0007439
TC16000582.hg
Participates
as a component of
IL34:CSF1 [extracellular region] (Homo sapiens)
IL34 dimer [extracellular region] (Homo sapiens)
as an input of
IL34 binds CSF1 (Homo sapiens)
IL34 dimerizes (Homo sapiens)
Inferred To
Il34 [extracellular region]
(Mus musculus)
Il34 [extracellular region]
(Rattus norvegicus)
il34 [extracellular region]
(Xenopus tropicalis)
si:ch211-239j19.3 [extracellular region]
(Danio rerio)
IL34 [extracellular region]
(Bos taurus)
IL34 [extracellular region]
(Canis familiaris)
IL34 [extracellular region]
(Gallus gallus)
IL34 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_689669.2
,
NP_001166242.1
,
XP_011521205.1
,
NP_001166243.1
,
XP_011521204.1
OpenTargets
ENSG00000157368
HPA
ENSG00000157368-IL34
GeneCards
Q6ZMJ4
Ensembl
ENSP00000397863
,
ENST00000429149
,
ENSG00000157368
,
ENSP00000288098
,
ENST00000288098
PRO
Q6ZMJ4
Pharos - Targets
Q6ZMJ4
PDB
4DKF
,
4DKD
,
4DKC
,
4DKE
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5T754 LCE1F
1
LCE1F [cytosol]
(R-HSA-6814270)
0.556
3
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