Phosphorylation of E proteins by p38 MAPK

Stable Identifier
R-HSA-448948
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nuclear envelope
ReviewStatus
5/5
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Phosphorylation of E proteins by p38 MAPK
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p38 MAPK plays a fundamental role in the transition of myoblasts to different myocytes. Activated p38 MAPK phosphorylates E12/E47, a member of the E protein subfamily of bHLH proteins. p38 MAPK in particular phosphorylates Ser140 of E47. Its been observed that phosphorylation of E47 improves its ability to form heterodimers with Myod transcription factor.

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Catalyst Activity

protein serine/threonine kinase activity of phospho-p38 alpha/beta/gamma MAPK [nucleoplasm]

Physical Entity
phospho-p38 alpha/beta/gamma MAPK [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Phosphorylation of E47 by p38 MAPK (Mus musculus)
Authored
Garapati, P V  (2008-08-11)
Reviewed
Krauss, RS  (2010-02-09)
Created
Garapati, P V  (2009-11-26)
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