Reactome | IL18(1-193) [cytosol]

IL18(1-193) [cytosol]

Stable Identifier

R-HSA-449033

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IL18, IL18 propeptide, Interleukin-18 propeptide, IL18_HUMAN

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
        
        Interleukin-1 family propeptides [cytosol] (Homo sapiens)
        
        IL18(1-193) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14116 IL18

Gene Names

IL18, IGIF, IL1F4

Chain

propeptide:1-36, chain:37-193

Reference Genes

BioGPS Gene:3606 IL18

COSMIC (genes):IL18 IL18

CTD Gene:3606 IL18

dbSNP Gene:3606 IL18

ENSEMBL:ENSG00000150782 IL18

ENSEMBL_homo_sapiens_GENE:ENSG00000150782.12 IL18

HGNC:5986 IL18

KEGG Gene (Homo sapiens):3606 IL18

Monarch:3606 IL18

NCBI Gene:3606 IL18

OMIM:600953 IL18

UCSC:Q14116 IL18

Reference Transcript

Other Identifiers

1165_at

11727092_x_at

16744415

206295_3p_at

206295_PM_at

206295_at

3391256

3391257

3391258

3391266

3391267

3391268

3391274

3391275

3391277

3391278

3606

7951686

A_23_P104798

D49950_at

GE57234

GO:0001525

GO:0002376

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006954

GO:0006955

GO:0007155

GO:0007267

GO:0008283

GO:0010468

GO:0010557

GO:0010628

GO:0010744

GO:0023052

GO:0030101

GO:0030154

GO:0030155

GO:0030431

GO:0032722

GO:0032725

GO:0032729

GO:0032736

GO:0032740

GO:0032819

GO:0034105

GO:0035655

GO:0036211

GO:0038061

GO:0042088

GO:0042092

GO:0042104

GO:0042119

GO:0042267

GO:0042531

GO:0042632

GO:0045515

GO:0045630

GO:0045662

GO:0045944

GO:0048018

GO:0048661

GO:0048856

GO:0050729

GO:0050830

GO:0051092

GO:0051142

GO:0051897

GO:0061436

GO:0070328

GO:0098542

GO:0098772

GO:0120162

GO:0150078

GO:1901224

GO:2000556

HMNXSV003036617

ILMN_1778457

TC11002293.hg

g4504652_3p_at

g4504652_3p_x_at

Participates

as a member of

Other forms of this molecule

IL18 [extracellular region]

IL18(1-36) [cytosol]

IL18 [cytosol]

Inferred To

il-1FMA [cytosol] (Danio rerio)

Homologues of IL18(1-193) [cytosol] (Sus scrofa)

Homologues of IL18(1-193) [cytosol] (Xenopus tropicalis)

Il18 [cytosol] (Mus musculus)

Il18 [cytosol] (Rattus norvegicus)

il1b [cytosol] (Xenopus tropicalis)

IL18 [cytosol] (Bos taurus)

IL18 [cytosol] (Canis familiaris)

IL18 [cytosol] (Sus scrofa)

LOC105946938 [cytosol] (Xenopus tropicalis)

IL-18 [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_001230140.1, NP_001553.1, XP_011541108.1, XP_011541107.1

OpenTargets

ENSG00000150782

GeneCards

Q14116

HPA

ENSG00000150782-IL18

Ensembl

ENST00000528832, ENSG00000150782, ENSP00000434161, ENST00000524595, ENSP00000434561, ENSP00000280357, ENST00000280357

PRO

Q14116

Pharos - Targets

Q14116

Orphanet

24619

PDB

4XFU, 4R6U, 1J0S, 4EKX, 4XFS, 3WO3, 3F62, 4XFT, 4EEE, 2VXT, 4HJJ, 3WO2, 3WO4, 7AL7

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13478 IL18R1	1	IL18R1 [plasma membrane] (R-HSA-197600)	0.558	2
UniProt:Q9IW12 Q9IW12			0.558	2
UniProt:Q15847 ADIRF	1	ADIRF [nucleoplasm] (R-HSA-8936822)	0.556	3