The mature and biologically active secreted interleukin-16 (IL16) is a 13-kDa carboxy terminal peptide derived from a larger intracellular precursor protein. Cleavage of IL16 from the propeptide is mediated by caspase-3. IL16 is a chemoattractant for a variety of cell types that express the cell surface antigen CD4.
Andrews, DW, Wu, DM, Center, DM, Zhang, Y, Yuan, J, Kornfeld, H, Cruikshank, WW
cysteine-type endopeptidase activator activity involved in apoptotic process of Caspase-3 [cytosol]
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