Interleukin-14, renamed alpha-taxilin (TXLNA) was originally described as High molecular weight B-cell growth factor (Ambrus et al. 1994). TXLNA binds several forms of syntaxin (Nogami et al. 2003), but not when they are complexed with SNAP25, VAMP2 or STXBP1, suggesting that TXLNA interacts with syntaxins outside the SNARE complex. This observation and a predicted role in intracellular vesicle trafficking led to renaming of the gene. Txlna transgenic mice show a phenotype similar to systemic lupus erythematosus and Sjogren's syndrome (Shen et al. 2006).