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STX1A [plasma membrane]
Stable Identifier
R-HSA-449128
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Syntaxin-1A, STX1A_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O75379 VAMP4
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Other interleukin signaling (Homo sapiens)
TXLNA (IL14) binds syntaxin1A (Homo sapiens)
STX1A [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Acetylcholine Neurotransmitter Release Cycle (Homo sapiens)
Acetylcholine synaptic vesicle docking and priming (Homo sapiens)
STX1A [plasma membrane] (Homo sapiens)
Dopamine Neurotransmitter Release Cycle (Homo sapiens)
Dopamine synaptic vesicle docking and priming (Homo sapiens)
STX1A [plasma membrane] (Homo sapiens)
GABA synthesis, release, reuptake and degradation (Homo sapiens)
GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)
STX1A [plasma membrane] (Homo sapiens)
Glutamate Neurotransmitter Release Cycle (Homo sapiens)
Glutamate synaptic vesicle docking and priming (Homo sapiens)
STX1A [plasma membrane] (Homo sapiens)
Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)
Noradrenalin synaptic vesicle docking and priming (Homo sapiens)
STX1A [plasma membrane] (Homo sapiens)
Serotonin Neurotransmitter Release Cycle (Homo sapiens)
Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)
STX1A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16623 STX1A
Gene Names
STX1A, STX1
Chain
chain:1-288
Reference Genes
BioGPS Gene:6804 STX1A
COSMIC (genes):STX1A STX1A
CTD Gene:6804 STX1A
dbSNP Gene:6804 STX1A
ENSEMBL:ENSG00000106089 STX1A
HGNC:11433 STX1A
KEGG:hsa:6804 STX1A
Monarch:6804 STX1A
NCBI Gene:6804 STX1A
OMIM:186590 STX1A
UCSC:Q16623 STX1A
Reference Transcript
RefSeq:NM_001165903.1 STX1A
RefSeq:NM_004603.3 STX1A
Other Identifiers
11720340_a_at
11748580_a_at
11751593_a_at
17058557
204729_PM_s_at
204729_s_at
3056227
3056228
3056229
3056230
3056231
3056232
3056233
3056234
3056235
3056236
3056237
3056238
3056239
3056240
3056241
3056242
3056243
3056244
3056245
3056246
3056248
3056249
3056254
3056256
3056257
37184_at
6804
8140113
A_23_P168556
A_23_P82420
A_24_P226541
A_33_P3212456
GE57747
GO:0000149
GO:0001956
GO:0005484
GO:0005515
GO:0005576
GO:0005829
GO:0005886
GO:0006836
GO:0006886
GO:0006887
GO:0008021
GO:0008076
GO:0010701
GO:0010807
GO:0012505
GO:0016020
GO:0016079
GO:0016192
GO:0016925
GO:0017156
GO:0019855
GO:0019869
GO:0019900
GO:0030073
GO:0030424
GO:0030672
GO:0031201
GO:0031410
GO:0031629
GO:0031965
GO:0032940
GO:0033605
GO:0042802
GO:0043005
GO:0043226
GO:0045055
GO:0045202
GO:0045956
GO:0046879
GO:0048278
GO:0048488
GO:0048787
GO:0050796
GO:0060090
GO:0061024
GO:0070044
GO:0098772
GO:2000463
HMNXSV003028015
HMNXSV003028213
ILMN_1760160
L37792_at
PH_hs_0004360
TC07001504.hg
g4759181_3p_a_at
Participates
as a component of
SNAP25:STX1A [plasma membrane] (Homo sapiens)
SNARE Complex [plasma membrane] (Homo sapiens)
STX1A:STXBP1 [plasma membrane] (Homo sapiens)
Core SNARE Complex [plasma membrane] (Homo sapiens)
STX1A:MUNC18 [plasma membrane] (Homo sapiens)
Docked dopamine loaded synaptic vesicle [plasma membrane] (Homo sapiens)
Docked acetylcholine loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
Docked Noradrenalin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
STXA1:SNAP25,STXBP2, VAMP2 [plasma membrane] (Homo sapiens)
TXLNA:STX1A [plasma membrane] (Homo sapiens)
Docked Glutamate Loaded Synaptic Vesicle [plasma membrane] (Homo sapiens)
Docked GABA loaded synaptic vesicle [cytosol] (Homo sapiens)
SNARE complex [plasma membrane] (Homo sapiens)
Docked serotonin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
as a member of
STX1 [plasma membrane] (Homo sapiens)
as an input of
Dopamine synaptic vesicle docking and priming (Homo sapiens)
Acetylcholine synaptic vesicle docking and priming (Homo sapiens)
Noradrenalin synaptic vesicle docking and priming (Homo sapiens)
TXLNA (IL14) binds syntaxin1A (Homo sapiens)
Glutamate synaptic vesicle docking and priming (Homo sapiens)
GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)
Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)
Other forms of this molecule
STX1A(?-288) [plasma membrane]
STX1A(1-?) [cytosol]
STX1A [cytosol]
STX1A [endoplasmic reticulum membrane]
Inferred To
Syx1A [plasma membrane]
(Drosophila melanogaster)
stx1a [plasma membrane]
(Xenopus tropicalis)
Stx1a [plasma membrane]
(Mus musculus)
Stx1a [plasma membrane]
(Rattus norvegicus)
unc-64 [plasma membrane]
(Caenorhabditis elegans)
STX1A [plasma membrane]
(Bos taurus)
STX1A [plasma membrane]
(Canis familiaris)
STX1A [plasma membrane]
(Gallus gallus)
STX1A [plasma membrane]
(Sus scrofa)
syn1A [plasma membrane]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001159375.1
,
NP_004594.1
OpenTargets
ENSG00000106089
ENSEMBL
ENSP00000222812
,
ENST00000395156
,
ENST00000222812
,
ENSP00000378585
HPA
ENSG00000106089-STX1A
PRO
Q16623
Pharos - Targets
Q16623
GlyGen
Q16623
Orphanet
STX1A
HMDB Protein
HMDBP14644
Interactors (120)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63027 VAMP2
20
VAMP2 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-379363)
VAMP2 [plasma membrane]
(R-HSA-210516)
VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917738)
VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-210365)
VAMP2 [synaptic vesicle membrane]
(R-HSA-181517)
VAMP2(59-116) [synaptic vesicle membrane]
(R-HSA-5250891)
VAMP2(2-58) [cytosol]
(R-HSA-194815)
VAMP2(2-76) [cytosol]
(R-HSA-194802)
VAMP2(77-116) [synaptic vesicle membrane]
(R-HSA-5228355)
VAMP2(60-116) [synaptic vesicle membrane]
(R-HSA-5250615)
VAMP2(2-59) [cytosol]
(R-HSA-194797)
VAMP2(82-116) [synaptic vesicle membrane]
(R-HSA-5250961)
VAMP2(2-81) [cytosol]
(R-HSA-5250970)
VAMP2 [secretory granule membrane]
(R-HSA-376363)
VAMP2 [cytosol]
(R-HSA-9609882)
VAMP2 [endoplasmic reticulum membrane]
(R-HSA-9609886)
VAMP2 [cytoplasmic vesicle membrane]
(R-HSA-1449630)
VAMP2 [lysosomal membrane]
(R-HSA-432703)
VAMP2 [Golgi membrane]
(R-HSA-375425)
VAMP2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869129)
0.666
5
UniProt:P40222 TXLNA
1
TXLNA [cytosol]
(R-HSA-449124)
0.666
4
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.666
5
UniProt:Q9H115 NAPB
1
NAPB [cytosol]
(R-HSA-5688553)
0.666
4
UniProt:P01375 TNF
5
TNF(1-233) [plasma membrane]
(R-HSA-66220)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
0.601
4
UniProt:Q16617 NKG7
0.601
4
UniProt:P09601 HMOX1
4
HMOX1 [cytosol]
(R-HSA-9609901)
HMOX1 [endoplasmic reticulum membrane]
(R-HSA-189395)
HMOX1 [mitochondrial outer membrane]
(R-HSA-9708524)
HMOX1 [nucleoplasm]
(R-HSA-9708567)
0.601
4
UniProt:P21145 MAL
0.601
4
UniProt:Q13021 MALL
0.556
3
UniProt:O95183 VAMP5
0.556
3
UniProt:Q92520 FAM3C
2
FAM3C [extracellular region]
(R-HSA-8848922)
FAM3C [platelet dense granule lumen]
(R-HSA-8848884)
0.556
3
UniProt:Q9H2L4 TMM60
0.556
3
UniProt:P52737 ZNF136
1
ZNF136 [nucleoplasm]
(R-HSA-975020)
0.556
3
UniProt:Q8WVX3-2 C4ORF3
0.556
3
UniProt:Q92482 AQP3
1
AQP3 [plasma membrane]
(R-HSA-431723)
0.556
3
UniProt:B2RUZ4 SMIM1
0.556
3
UniProt:Q8IYI8 ZNF440
1
ZNF440 [nucleoplasm]
(R-HSA-1247548)
0.556
3
UniProt:Q15836 VAMP3
6
VAMP3 [recycling endosome membrane]
(R-HSA-2029063)
VAMP3 [phagocytic vesicle membrane]
(R-HSA-2029013)
VAMP3 [plasma membrane]
(R-HSA-8867599)
VAMP3 [trans-Golgi network membrane]
(R-HSA-6814624)
VAMP3 [transport vesicle]
(R-HSA-6814625)
VAMP3 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869130)
0.556
3
UniProt:Q96IW7 SEC22A
3
SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688562)
SEC22A [ER to Golgi transport vesicle membrane]
(R-HSA-5688560)
SEC22A [endoplasmic reticulum membrane]
(R-HSA-5216111)
0.556
3
UniProt:Q96C28 ZNF707
1
ZNF707 [nucleoplasm]
(R-HSA-2454161)
0.556
3
UniProt:Q9BZL3 SMIM3
0.556
3
UniProt:Q86Y82 STX12
0.556
3
UniProt:Q8N8Z8 ZNF441
1
ZNF441 [nucleoplasm]
(R-HSA-1247518)
0.556
3
UniProt:Q5SQN1 SNP47
0.556
3
UniProt:Q96HV5 TM41A
0.556
3
UniProt:Q96F15 GIMA5
0.556
3
UniProt:P26678 PLN
2
p-S16-PLN [sarcoplasmic reticulum membrane]
(R-HSA-5578813)
PLN [sarcoplasmic reticulum membrane]
(R-HSA-5490319)
0.556
3
UniProt:Q8N5M9 JAGN1
0.556
3
UniProt:P78317 RNF4
2
RNF4 [nucleoplasm]
(R-HSA-5684076)
RNF4 [cytosol]
(R-HSA-975974)
0.556
3
UniProt:Q8IY26 PLPP6
1
PLPP6 [plasma membrane]
(R-HSA-8952144)
0.556
3
UniProt:Q9NVV5-2 AIG1
0.556
3
UniProt:Q96FZ5 CKLF7
0.556
3
UniProt:A8K8V0 ZNF785
1
ZNF785 [nucleoplasm]
(R-HSA-3323098)
0.556
3
UniProt:O75396 SEC22B
6
SEC22B [endoplasmic reticulum membrane]
(R-HSA-5688150)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688566)
SEC22B [ER to Golgi transport vesicle membrane]
(R-HSA-5688565)
SEC22B [phagocytic vesicle membrane]
(R-HSA-8863938)
SEC22B [transport vesicle]
(R-HSA-6810994)
SEC22B [Golgi membrane]
(R-HSA-6810993)
0.556
3
UniProt:Q8IXM6 NRM
0.556
3
UniProt:O75558 STX11
0.556
3
UniProt:Q4LEZ3 AARD
0.556
3
UniProt:O00559 EBAG9
1
EBAG9 [Golgi membrane]
(R-HSA-9018507)
0.556
3
UniProt:Q7KZS0 Q7KZS0
0.556
3
UniProt:O15400 STX7
0.556
3
UniProt:A0AVG3 A0AVG3
0.556
3
UniProt:Q9P2A4 ABI3
0.556
3
UniProt:Q8N511 TM199
0.556
3
UniProt:Q8N8B7-2 TCEANC
0.556
3
UniProt:Q9NVF9 ETNK2
1
ETNK2 [cytosol]
(R-HSA-1498759)
0.556
3
UniProt:Q6RW13-2 AGTRAP
0.556
3
UniProt:Q5VZY2 PLPP4
1
PPAPDC1A [plasma membrane]
(R-HSA-2029082)
0.556
3
UniProt:P30301 MIP
1
MIP [plasma membrane]
(R-HSA-432026)
0.556
3
UniProt:O75841 UPK1B
0.556
3
UniProt:Q3SY00 T10IP
0.556
3
UniProt:O95159 ZFPL1
0.556
3
UniProt:Q9UNK0 STX8
0.556
3
UniProt:Q5BJH2-2 TMEM128
0.556
3
UniProt:P15622-3 ZNF250
0.556
3
UniProt:P0DN84 DWORF
0.556
3
UniProt:Q9Y2P0 ZN835
0.556
3
UniProt:Q6UX34 SNORC
0.556
3
UniProt:Q9Y6X1 SERP1
2
SERP1 [endoplasmic reticulum membrane]
(R-HSA-381045)
SERP1 [cytosol]
(R-HSA-5250574)
0.556
3
UniProt:Q86W74-2 ANKRD46
0.556
3
UniProt:Q9NZG7 NINJ2
0.556
3
IntAct:EBI-22331701 CCSB ORF ID
0.556
3
UniProt:Q8N4V1 MMGT1
1
MMGT1 [Golgi membrane]
(R-HSA-5216137)
0.556
3
IntAct:EBI-23653849 CCSB ORF ID
0.556
3
UniProt:P23763-3 VAMP1
0.556
3
UniProt:Q8WVV5 BTN2A2
1
BTN2A2 [plasma membrane]
(R-HSA-8851047)
0.556
3
UniProt:P17014 ZNF12
1
ZNF12(1-501) [nucleoplasm]
(R-HSA-974989)
0.556
3
UniProt:O60499-2 STX10
0.556
3
UniProt:Q9NWW5 CLN6
0.556
3
UniProt:O75379 VAMP4
4
VAMP4 [transport vesicle]
(R-HSA-6811023)
VAMP4 [trans-Golgi network membrane]
(R-HSA-6811021)
VAMP4 [plasma membrane]
(R-HSA-8864461)
VAMP4 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869133)
0.556
3
UniProt:Q9NZ43 USE1
1
USE1 [endoplasmic reticulum membrane]
(R-HSA-2193119)
0.556
3
UniProt:O14653 GOSR2
4
GOSR2 [endoplasmic reticulum membrane]
(R-HSA-5689451)
GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-535472)
GOSR2 [ER to Golgi transport vesicle membrane]
(R-HSA-5689800)
GOSR2 [Golgi membrane]
(R-HSA-6807755)
0.556
6
UniProt:P54315 PNLIPRP1
1
PNLIPRP1 [extracellular region]
(R-HSA-3902876)
0.556
3
UniProt:Q8N6R1 SERP2
0.556
3
UniProt:P0CB47 UBFL1
0.556
3
UniProt:Q13491-3 GPM6B
0.556
3
UniProt:Q8WWP7 GIMA1
0.556
3
UniProt:Q9UKR5 ERG28
0.556
3
UniProt:Q9UHJ9-5 PGAP2
0.556
3
UniProt:P60033 CD81
1
CD81 [plasma membrane]
(R-HSA-197933)
0.556
3
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.556
3
UniProt:Q96LZ7 RMD2
0.556
3
UniProt:Q9Y6V7 DDX49
1
DDX49 [nucleoplasm]
(R-HSA-6790725)
0.556
3
UniProt:Q9UL45 BLOC1S6
1
BLOC1S6 [cytosol]
(R-HSA-429816)
0.556
3
UniProt:Q9ULM2 ZNF490
1
ZNF490 [nucleoplasm]
(R-HSA-1247870)
0.556
3
UniProt:O15155 BET1
3
BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688142)
BET1 [transport vesicle]
(R-HSA-6808719)
BET1 [Golgi membrane]
(R-HSA-6807743)
0.556
3
UniProt:Q12846 STX4
4
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.556
3
UniProt:O43752 STX6
2
STX6 [trans-Golgi network membrane]
(R-HSA-6811007)
STX6 [Golgi membrane]
(R-HSA-6811004)
0.556
3
UniProt:Q5QGT7 RTP2
2
RTP2 [endoplasmic reticulum membrane]
(R-HSA-9752982)
RTP2 [plasma membrane]
(R-HSA-8939446)
0.556
3
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
UniProt:Q13190 STX5
5
STX5 [cytosol]
(R-HSA-9613991)
STX5 [Golgi membrane]
(R-HSA-6807771)
STX5 [ER to Golgi transport vesicle membrane]
(R-HSA-5689838)
STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688157)
STX5 [endoplasmic reticulum membrane]
(R-HSA-5689474)
0.556
3
UniProt:Q8IW00 VSTM4
0.556
3
UniProt:Q96JC4 ZNF479
1
ZNF479 [nucleoplasm]
(R-HSA-1247855)
0.556
3
UniProt:Q8N988-2 ZNF557
0.556
3
UniProt:Q9BQE5 APOL2
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:O43169 CYB5B
2
CYB5B [endoplasmic reticulum membrane]
(R-HSA-9842695)
CYB5B [mitochondrial outer membrane]
(R-HSA-8943390)
0.556
3
UniProt:Q9P0S9 TM14C
0.556
3
UniProt:CXCL16 A0A6I8PIU0
0.556
3
UniProt:O14662-5 STX16
0.556
3
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.556
3
UniProt:Q9BXJ8 TACAN
0.556
3
UniProt:P32856-2 STX2
0.556
3
UniProt:Q12981 BNIP1
1
BNIP1 [endoplasmic reticulum membrane]
(R-HSA-6810950)
0.556
3
UniProt:Q13277 STX3
1
STX3 [plasma membrane]
(R-HSA-449131)
0.556
3
UniProt:Q9Y228 T3JAM
0.556
3
UniProt:Q8TBN0 RAB3IL1
1
RAB3IL1 [cytosol]
(R-HSA-8875296)
0.556
3
UniProt:Q8TBM7 TM254
0.556
3
UniProt:Q9UEU0 VTI1B
2
VTI1B [extracellular region]
(R-HSA-8862983)
VTI1B [platelet alpha granule lumen]
(R-HSA-8862964)
0.556
3
UniProt:P60201-2 PLP1
0.556
3
UniProt:Q8NC01 CLC1A
0.556
3
UniProt:O95236-2 APOL3
0.556
3
UniProt:Q9NV29 TM100
0.556
3
UniProt:Q9H0R3 TM222
0.556
3
UniProt:Q9H7X3 ZNF696
1
ZNF696 [nucleoplasm]
(R-HSA-2454138)
0.556
3
UniProt:Q16853 AOC3
1
AOC3 [plasma membrane]
(R-HSA-5696151)
0.556
3
UniProt:O00161 SNAP23
5
p-S95-SNAP23 [phagocytic vesicle membrane]
(R-HSA-8863923)
SNAP23 [phagocytic vesicle membrane]
(R-HSA-8863966)
SNAP23 [tertiary granule membrane]
(R-HSA-6806141)
SNAP23 [plasma membrane]
(R-HSA-376345)
SNAP23 [specific granule membrane]
(R-HSA-6806157)
0.553
2
UniProt:O95721 SNAP29
3
SNAP29 [azurophil granule membrane]
(R-HSA-6799359)
SNAP29 [plasma membrane]
(R-HSA-2029020)
SNAP29 [Golgi membrane]
(R-HSA-6810997)
0.553
2
UniProt:P60880 SNAP25
7
SNAP25(1-197) [plasma membrane]
(R-HSA-3004546)
SNAP25(198-206) [cytosol]
(R-HSA-5244499)
SNAP25(1-198) [plasma membrane]
(R-HSA-3004550)
SNAP25(199-206) [cytosol]
(R-HSA-5244501)
SNAP25 [tertiary granule membrane]
(R-HSA-6806142)
SNAP25 [specific granule membrane]
(R-HSA-6806154)
SNAP25 [plasma membrane]
(R-HSA-2029017)
0.547
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.499
2
UniProt:P60880-2 SNAP25
0.499
5
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