Reactome | Signaling by Interleukins

Signaling by Interleukins

Stable Identifier

R-HSA-449147

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Signaling by Interleukins and related cytokines

ReviewStatus

5/5

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Interleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but are now known to be produced by many other cells throughout the body. They have pleiotropic effects on cells which bind them, impacting processes such as tissue growth and repair, hematopoietic homeostasis, and multiple levels of the host defense against pathogens where they are an essential part of the immune system.

Literature References

PubMed ID	Title	Journal	Year
12445398	Interleukin signaling Vosshenrich, CA, Di Santo, JP	Curr Biol	2002
27577879	Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases Komlosi, Z, Kucuksezer, UC, Frei, R, Huitema, C, Garbani, M, Pezer, M, Olzhausen, J, Stanic, B, Kubo, T, Kovacs, N, Konieczna, P, Hess, L, Ferstl, R, Wawrzyniak, P, Globinska, A, Sugita, K, Eljaszewicz, A, Altunbulakli, C, Meyer, N, Akdis, M, Wanke, K, O'Mahony, L, Costa, RA, Aab, A, Duan, S, Azkur, K, Wawrzyniak, M, Rinaldi, A, Rhyner, C, Zakzuk, JS, Crameri, R, Morita, H, Rebane, A, Wirz, OF, Prati, M, Treis, A, Akdis, CA, Van De Veen, W, Sokolowska, M, Eiwegger, T	J. Allergy Clin. Immunol.	2016
19302047	Immunological and inflammatory functions of the interleukin-1 family Dinarello, CA	Annu Rev Immunol	2009