Reactome | DOLK [endoplasmic reticulum membrane]

DOLK [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-449274

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Dolichol kinase, DOLK_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q8TD20 SLC2A12

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of Dolichyl-phosphate (Homo sapiens)
        
        DOLK phosphorylates DCHOL to DOLP (Homo sapiens)
        
        DOLK [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UPQ8 DOLK

Gene Names

DOLK, KIAA1094, TMEM15, UNQ2422/PRO4980

Chain

chain:1-538

Reference Genes

BioGPS Gene:22845 DOLK

COSMIC (genes):DOLK DOLK

CTD Gene:22845 DOLK

dbSNP Gene:22845 DOLK

ENSEMBL:ENSG00000175283 DOLK

ENSEMBL_homo_sapiens_GENE:ENSG00000175283.8 DOLK

HGNC:23406 DOLK

KEGG Gene (Homo sapiens):22845 DOLK

Monarch:22845 DOLK

NCBI Gene:22845 DOLK

OMIM:610746 DOLK

UCSC:Q9UPQ8 DOLK

Reference Transcript

RefSeq:NM_014908.3 DOLK

Other Identifiers

11724825_a_at

11752810_a_at

17098974

204488_PM_at

204488_at

22845

3226790

3226791

3226792

3226793

3226794

3226795

35403_at

8164515

A_23_P10870

GE53743

GO:0003824

GO:0004168

GO:0005515

GO:0005783

GO:0005789

GO:0006486

GO:0006489

GO:0006629

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0036211

GO:0043048

GO:0043226

GO:1901135

HMNXSV003025537

ILMN_1753627

PH_hs_0026195

TC09001641.hg

g7662481_3p_at

Other forms of this molecule

DOLK M1I [endoplasmic reticulum membrane]

DOLK H408D [endoplasmic reticulum membrane]

DOLK C99S [endoplasmic reticulum membrane]

DOLK W304C [endoplasmic reticulum membrane]

DOLK Y441S [endoplasmic reticulum membrane]

Inferred To

DOLK [endoplasmic reticulum membrane] (Bos taurus)

DOLK [endoplasmic reticulum membrane] (Canis familiaris)

DOLK [endoplasmic reticulum membrane] (Dictyostelium discoideum)

DOLK [endoplasmic reticulum membrane] (Gallus gallus)

DOLK [endoplasmic reticulum membrane] (Sus scrofa)

SEC59 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

dolk [endoplasmic reticulum membrane] (Danio rerio)

dolk [endoplasmic reticulum membrane] (Xenopus tropicalis)

sec59 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Dolk [endoplasmic reticulum membrane] (Drosophila melanogaster)

Dolk [endoplasmic reticulum membrane] (Mus musculus)

Dolk [endoplasmic reticulum membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_055723.1

OpenTargets

ENSG00000175283

GeneCards

Q9UPQ8

HPA

ENSG00000175283-DOLK

Ensembl

ENSG00000175283, ENST00000372586, ENSP00000361667

PRO

Q9UPQ8

Pharos - Targets

Q9UPQ8

Orphanet

16439

HMDB Protein

HMDBP09153

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HCJ2 LRC4C			0.742	5
UniProt:P17658 KCNA6	1	KCNA6 [plasma membrane] (R-HSA-977470)	0.742	6
UniProt:Q92838 EDA	1	EDA [plasma membrane] (R-HSA-5667156)	0.718	6
UniProt:P22001 KCNA3	1	KCNA3 [plasma membrane] (R-HSA-977475)	0.718	6
UniProt:Q8TBG9 SYNPR			0.556	3
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:Q8TBE3 FNDC9			0.556	3
UniProt:Q9H9P2 CHODL			0.556	3
UniProt:P48165 GJA8	1	GJA8 [endoplasmic reticulum membrane] (R-HSA-190702)	0.556	3
UniProt:Q9H7M9 VISTA			0.556	3
UniProt:Q92624 APBP2			0.556	3
UniProt:Q96B21 TM45B			0.556	3
UniProt:Q16322 KCNA10	1	KCNA10 [plasma membrane] (R-HSA-977480)	0.556	5
UniProt:Q96HE8 TMM80			0.556	3
UniProt:Q92536 SLC7A6	1	SLC7A6 [plasma membrane] (R-HSA-379425)	0.556	3
UniProt:Q09470 KCNA1	1	KCNA1 [plasma membrane] (R-HSA-977482)	0.556	7
UniProt:Q5JX71 F209A			0.556	3
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q9NZQ7 CD274	1	CD274 [plasma membrane] (R-HSA-3211776)	0.527	2
UniProt:P22460 KCNA5	1	KCNA5 [plasma membrane] (R-HSA-977472)	0.527	2
UniProt:Q8TD20 SLC2A12	1	SLC2A12 [plasma membrane] (R-HSA-429046)	0.527	2
UniProt:Q8WVE6 TM171			0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:P25090 FPR2	4	FPR2 [specific granule membrane] (R-HSA-6803319) FPR2 [ficolin-1-rich granule membrane] (R-HSA-6803335) FPR2 [tertiary granule membrane] (R-HSA-6803296) FPR2 [plasma membrane] (R-HSA-416408)	0.527	2

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