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CDC42 [plasma membrane]
Stable Identifier
R-HSA-449545
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Cell division control protein 42 homolog, CDC42_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:O15511 ARPC5
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through CDC42 (Homo sapiens)
CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Homo sapiens)
CDC42 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60953 CDC42
Gene Names
CDC42, cell division cycle 42
Chain
chain:1-188, propeptide:189-191
Reference Genes
COSMIC (genes):CDC42 CDC42
dbSNP Gene:998 CDC42
ENSEMBL:ENSG00000070831 CDC42
Participates
as a candidate of
RHOV effectors [cytosol] (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
as a component of
CDC42:GDP [plasma membrane] (Homo sapiens)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Homo sapiens)
CDC42-GDP [plasma membrane] (Homo sapiens)
CDC42:GTP [plasma membrane] (Homo sapiens)
CDC42:GTP [plasma membrane] (Homo sapiens)
as an input of
CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Homo sapiens)
Other forms of this molecule
CDC42 [cytosol]
CDC42 [endoplasmic reticulum membrane]
Inferred To
cdc42 [plasma membrane]
(Danio rerio)
cdc42 [plasma membrane]
(Xenopus tropicalis)
Cdc42 [plasma membrane]
(Mus musculus)
CDC42 [plasma membrane]
(Bos taurus)
CDC42 [plasma membrane]
(Caenorhabditis elegans)
CDC42 [plasma membrane]
(Canis familiaris)
CDC42 [plasma membrane]
(Dictyostelium discoideum)
CDC42 [plasma membrane]
(Drosophila melanogaster)
CDC42 [plasma membrane]
(Gallus gallus)
CDC42 [plasma membrane]
(Rattus norvegicus)
CDC42 [plasma membrane]
(Saccharomyces cerevisiae)
CDC42 [plasma membrane]
(Schizosaccharomyces pombe)
CDC42 [plasma membrane]
(Sus scrofa)
Interactors (52)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.957
19
UniProt:P42768 WAS
2
p-Y291-WAS [cytosol]
(R-HSA-2197668)
WAS [cytosol]
(R-HSA-201879)
0.949
14
UniProt:Q13153 PAK1
5
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
PAK1 [cytosol]
(R-HSA-162629)
Active PAK1 [cytosol]
(R-HSA-8964622)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
PAK1 [plasma membrane]
(R-HSA-3928409)
0.944
15
UniProt:Q9BYG5 PARD6B
2
PARD6B [plasma membrane]
(R-HSA-418193)
PARD6B [cytosol]
(R-HSA-419973)
0.896
18
UniProt:Q00587 CDC42EP1
1
CDC42EP1 [cytosol]
(R-HSA-9691382)
0.886
9
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
0.874
9
UniProt:O14613 CDC42EP2
2
p-CDC42EP2 [cytosol]
(R-HSA-5692662)
CDC42EP2 [cytosol]
(R-HSA-5692692)
0.83
10
UniProt:O96013 PAK4
1
PAK4 [cytosol]
(R-HSA-428461)
0.825
5
UniProt:Q5VT25 CDC42BPA
1
CDC42BPA [cytosol]
(R-HSA-419871)
0.815
6
GTP [ChEBI:15996]
7
GTP [cilium]
(R-ALL-5617813)
GTP [early endosome membrane]
(R-ALL-2130170)
GTP [lysosomal membrane]
(R-ALL-2213216)
GTP [platelet dense granule lumen]
(R-ALL-114625)
GTP [cytoplasmic vesicle membrane]
(R-ALL-1996291)
GTP [ER to Golgi transport vesicle membrane]
(R-ALL-983318)
GTP [Golgi membrane]
(R-ALL-1806221)
0.797
8
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.794
10
UniProt:P52565 ARHGDIA
1
ARHGDIA [cytosol]
(R-HSA-194478)
0.756
5
UniProt:Q9NPB6 PARD6A
4
PARD6A [plasma membrane]
(R-HSA-418187)
PARD6A [cytosol]
(R-HSA-420001)
PARD6A [cell junction]
(R-HSA-2134480)
p-S345-PARD6A [plasma membrane]
(R-HSA-2134533)
0.755
7
UniProt:O00401 WASL
4
p-Y256-WASL [cytosol]
(R-HSA-2197672)
N-WASP [cytosol]
(R-HSA-201873)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.75
4
UniProt:Q9P286 PAK5
2
PAK5 [cytosol]
(R-HSA-428459)
PAK7 [plasma membrane]
(R-HSA-211555)
0.743
5
UniProt:Q9JK83
2
Pard6b [plasma membrane]
(R-MMU-418193)
Pard6b [cytosol]
(R-MMU-419973)
0.729
6
UniProt:Q9NRR3 CDC42SE2
1
CDC42SE2 [plasma membrane]
(R-HSA-9714853)
0.725
5
UniProt:Q13576 IQGAP2
3
IQGAP2 [plasma membrane]
(R-HSA-6804811)
IQGAP2 [secretory granule membrane]
(R-HSA-6804779)
IQGAP2 [cytosol]
(R-HSA-5625975)
0.688
4
UniProt:Q9BYG4 PARD6G
2
PARD6G [plasma membrane]
(R-HSA-418192)
PARD6G [cytosol]
(R-HSA-419967)
0.681
5
UniProt:P19878 NCF2
2
NCF2 [cytosol]
(R-HSA-1222600)
p-T233-NCF2 [phagolysosome]
(R-HSA-1996211)
0.676
3
UniProt:P41743 PRKCI
3
PRKCI [nucleoplasm]
(R-HSA-9021345)
PRKCI [cytosol]
(R-HSA-58206)
PRKCI [plasma membrane]
(R-HSA-420005)
0.67
5
UniProt:P25054 APC
20
APC R213* [cytosol]
(R-HSA-9666924)
APC C1410* [cytosol]
(R-HSA-9666925)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
0.668
9
UniProt:Q9UQB8-4 BAIAP2
0.667
4
UniProt:Q9NQU5 PAK6
1
PAK6 [cytosol]
(R-HSA-428454)
0.659
4
UniProt:Q9NRR8 C42S1
0.659
3
UniProt:Q61036 Pak3
3
phospho-p-S154,T436-PAK3 [plasma membrane]
(R-MMU-3928479)
phospho-p-S154,T436-PAK3 [cytosol]
(R-MMU-5357471)
Pak3 [cytosol]
(R-MMU-442833)
0.656
3
UniProt:Q86VI3 IQGAP3
1
IQGAP3 [cytosol]
(R-HSA-5625977)
0.643
5
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.621
3
UniProt:Q92963 RIT1
1
RIT1 [plasma membrane]
(R-HSA-187703)
0.619
6
UniProt:Q15642 TRIP10
1
TRIP10 [cytosol]
(R-HSA-195120)
0.609
2
UniProt:O30916 SOPB
0.602
5
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.573
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.564
2
UniProt:O52623 SOPE
0.558
2
UniProt:Q00587-2 CDC42EP1
0.556
3
UniProt:Q8WUI4-6 HDAC7
0.556
3
UniProt:B2RTY4 MYO9A
1
MYO9A [cytosol]
(R-HSA-200628)
0.553
2
UniProt:Q9H3Q1 CDC42EP4
1
CDC42EP4 [cytosol]
(R-HSA-9691381)
0.547
2
UniProt:P35268 RPL22
1
RPL22 [cytosol]
(R-HSA-72428)
0.547
2
UniProt:P52306 RAP1GDS1
1
RAP1GDS1 [mitochondrial outer membrane]
(R-HSA-9693756)
0.547
2
UniProt:Q9Y5S2 CDC42BPB
1
CDC42BPB [cytosol]
(R-HSA-419873)
0.547
2
UniProt:Q16584 MAP3K11
1
MAP3K11 [cytosol]
(R-HSA-449607)
0.536
3
UniProt:Q9VEX9
1
Bin1 [nucleoplasm]
(R-DME-351694)
0.527
2
UniProt:P60660 MYL6
2
p-S20-MYL6 [cytosol]
(R-HSA-445778)
MYL6 [cytosol]
(R-HSA-419186)
0.527
2
UniProt:Q9UHB6 LIMA1
0.527
2
UniProt:O15511 ARPC5
4
ARPC5 [ficolin-1-rich granule lumen]
(R-HSA-6801065)
ARPC5 [extracellular region]
(R-HSA-6806476)
ARPC5 [secretory granule lumen]
(R-HSA-6801071)
ARPC5 [cytosol]
(R-HSA-200806)
0.527
2
UniProt:O08816 Wasl
1
N-Wasp [cytosol]
(R-RNO-442543)
0.524
2
UniProt:P60953 CDC42
3
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
0.524
2
UniProt:O95477 ABCA1
11
ABCA1 [plasma membrane]
(R-HSA-194209)
4xPALM-C-p-2S-ABCA1 [plasma membrane]
(R-HSA-5682069)
4xPALM-C-ABCA1 [endoplasmic reticulum membrane]
(R-HSA-5682085)
4xPALM-C-ABCA1 [plasma membrane]
(R-HSA-5682091)
ABCA1 [endoplasmic reticulum membrane]
(R-HSA-5682105)
ABCA1 Q537R [plasma membrane]
(R-HSA-5682199)
ABCA1 R587W [plasma membrane]
(R-HSA-5682197)
ABCA1 S1446L [plasma membrane]
(R-HSA-5682195)
ABCA1 C1417R [plasma membrane]
(R-HSA-5682190)
ABCA1 N935S [plasma membrane]
(R-HSA-5682200)
ABCA1 W590S [plasma membrane]
(R-HSA-5682201)
0.524
2
UniProt:Q96L34 MARK4
1
MARK4 [cytosol]
(R-HSA-5626653)
0.499
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
11
UniProt:P45983 MAPK8
3
MAPK8 [cytosol]
(R-HSA-168141)
p-T,Y-MAPK8 [cytosol]
(R-HSA-194371)
p-T,Y-MAPK8 [nucleoplasm]
(R-HSA-216349)
0.483
2
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