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CDC42 [plasma membrane]
Stable Identifier
R-HSA-449545
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Cell division control protein 42 homolog, CDC42_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9UQB8 BAIAP2
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through CDC42 (Homo sapiens)
CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Homo sapiens)
CDC42 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60953 CDC42
Gene Names
CDC42, cell division cycle 42
Chain
chain:1-188, propeptide:189-191
Reference Genes
BioGPS Gene:998 CDC42
COSMIC (genes):CDC42 CDC42
CTD Gene:998 CDC42
dbSNP Gene:998 CDC42
ENSEMBL:ENSG00000070831 CDC42
ENSEMBL_homo_sapiens_GENE:ENSG00000070831.18 CDC42
HGNC:1736 CDC42
KEGG Gene (Homo sapiens):998 CDC42
Monarch:998 CDC42
NCBI Gene:998 CDC42
OMIM:116952 CDC42
UCSC:P60953 CDC42
Reference Transcript
RefSeq:NM_001039802.1 CDC42
RefSeq:NM_001791.3 CDC42
RefSeq:NM_044472.2 CDC42
Other Identifiers
11721885_s_at
11721886_a_at
11725717_at
11725718_a_at
11725719_s_at
11725720_x_at
11729102_x_at
11753606_x_at
11756249_x_at
16660503
208727_PM_s_at
208727_s_at
208728_3p_s_at
208728_PM_s_at
208728_s_at
210232_PM_at
210232_at
214230_PM_at
214230_at
2324635
2324636
2324637
2324638
2324639
2324640
2324643
2324646
2324647
2324650
2324652
2324653
2324654
2324660
2324661
2324662
2324663
2324664
2324665
2324666
2324667
2324668
2324669
2324670
2324671
2324672
2324680
2324682
2324684
2324685
2763403
2763404
2763405
2763406
2763408
2763409
3003101
3003102
3003104
3003106
3051737
3119340
39736_at
4006960
7898739
959_at
960_g_at
998
A_14_P125675
A_19_P00330417
A_23_P200560
A_23_P300056
A_24_P42633
A_24_P453532
GE510780
GE57603
GE86095
GO:0000139
GO:0000166
GO:0000278
GO:0000322
GO:0000910
GO:0002040
GO:0002376
GO:0003013
GO:0003015
GO:0003161
GO:0003253
GO:0003824
GO:0003924
GO:0003925
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005737
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005925
GO:0005938
GO:0006260
GO:0006886
GO:0006897
GO:0006911
GO:0007010
GO:0007015
GO:0007018
GO:0007030
GO:0007059
GO:0007088
GO:0007097
GO:0007155
GO:0007163
GO:0007229
GO:0007264
GO:0007399
GO:0008104
GO:0009653
GO:0010591
GO:0010592
GO:0012501
GO:0016020
GO:0016192
GO:0016740
GO:0016787
GO:0017119
GO:0019901
GO:0021762
GO:0023052
GO:0030036
GO:0030141
GO:0030154
GO:0030175
GO:0030225
GO:0030307
GO:0030335
GO:0030425
GO:0030496
GO:0030742
GO:0031252
GO:0031256
GO:0031274
GO:0031333
GO:0031410
GO:0031435
GO:0031996
GO:0032427
GO:0032467
GO:0032488
GO:0032956
GO:0032991
GO:0034191
GO:0034329
GO:0034330
GO:0034332
GO:0035050
GO:0035088
GO:0036336
GO:0036464
GO:0038189
GO:0042802
GO:0042995
GO:0043005
GO:0043025
GO:0043197
GO:0043226
GO:0043227
GO:0043410
GO:0043525
GO:0044788
GO:0045177
GO:0045198
GO:0045335
GO:0045740
GO:0046330
GO:0046847
GO:0048549
GO:0048664
GO:0048856
GO:0048870
GO:0051130
GO:0051233
GO:0051489
GO:0051491
GO:0051492
GO:0051496
GO:0051647
GO:0051649
GO:0051683
GO:0051835
GO:0051897
GO:0051988
GO:0060047
GO:0060071
GO:0060501
GO:0060661
GO:0060997
GO:0061024
GO:0061630
GO:0065003
GO:0070062
GO:0071346
GO:0071944
GO:0072384
GO:0072686
GO:0086101
GO:0090135
GO:0090316
GO:0098542
GO:0098685
GO:0098772
GO:0098978
GO:0099159
GO:0099175
GO:0099563
GO:0140014
GO:0140096
GO:1900026
HMNXSV003001828
HMNXSV003003678
HMNXSV003026991
HMNXSV003045847
Hs.146409.3.S1_3p_at
Hs2.384596.1.S1_3p_at
ILMN_1675156
ILMN_1696041
ILMN_1738424
ILMN_2408139
PH_hs_0029852
PH_hs_0040005
TC01000280.hg
g12803746_3p_a_at
g13277547_3p_at
g13277547_3p_s_at
g182856_3p_at
Participates
as a candidate of
RHOV effectors [cytosol] (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
as a component of
CDC42:GDP [plasma membrane] (Homo sapiens)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Homo sapiens)
CDC42-GDP [plasma membrane] (Homo sapiens)
CDC42:GTP [plasma membrane] (Homo sapiens)
CDC42:GTP [plasma membrane] (Homo sapiens)
as an input of
CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Homo sapiens)
Other forms of this molecule
CDC42 [endoplasmic reticulum membrane]
CDC42 [cytosol]
Inferred To
cdc42 [plasma membrane]
(Danio rerio)
cdc42 [plasma membrane]
(Xenopus tropicalis)
Cdc42 [plasma membrane]
(Mus musculus)
CDC42 [plasma membrane]
(Bos taurus)
CDC42 [plasma membrane]
(Caenorhabditis elegans)
CDC42 [plasma membrane]
(Canis familiaris)
CDC42 [plasma membrane]
(Dictyostelium discoideum)
CDC42 [plasma membrane]
(Drosophila melanogaster)
CDC42 [plasma membrane]
(Gallus gallus)
CDC42 [plasma membrane]
(Rattus norvegicus)
CDC42 [plasma membrane]
(Saccharomyces cerevisiae)
CDC42 [plasma membrane]
(Schizosaccharomyces pombe)
CDC42 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001782.1
,
NP_001034891.1
,
NP_426359.1
OpenTargets
ENSG00000070831
ZINC - Substances
CDC42_HUMAN
ZINC target
P60953
ZINC - Biogenic
CDC42_HUMAN
PRO
P60953
PDB
5UPK
,
1DOA
,
4DID
,
2WMO
,
2WMN
,
6TKZ
,
6TKY
,
1GZS
,
1GRN
,
6AJ4
,
1E0A
,
5UPL
,
2QRZ
,
4YDH
,
8I5F
,
4YC7
,
3QBV
,
1CF4
,
2KB0
,
1KZG
,
3GCG
,
2WM9
,
3VHL
,
5CJP
,
2ASE
,
6SUP
,
1A4R
,
5HZK
,
2DFK
,
2NGR
,
1KI1
,
1NF3
,
1AM4
,
6AJL
,
1EES
,
7S0Y
,
4JS0
,
5FI1
,
6SIU
,
4ITR
,
1AJE
,
2ODB
,
1KZ7
,
1AN0
,
1CEE
IntEnz
3.6.5.2
GeneCards
P60953
HPA
ENSG00000070831-CDC42
Ensembl
ENSP00000314458
,
ENSP00000512180
,
ENSP00000512182
,
ENST00000411827
,
ENST00000400259
,
ENST00000344548
,
ENSP00000398327
,
ENSP00000383118
,
ENSP00000341072
,
ENSP00000512222
,
ENSP00000512225
,
ENST00000695800
,
ENST00000315554
,
ENSP00000512179
,
ENSP00000512178
,
ENSP00000512177
,
ENSP00000512176
,
ENST00000695860
,
ENST00000695802
,
ENST00000662562
,
ENSG00000070831
,
ENSP00000499457
,
ENST00000695797
,
ENST00000695796
,
ENSP00000499612
,
ENST00000695799
,
ENST00000695798
,
ENST00000695857
,
ENST00000656825
Pharos - Targets
P60953
ZINC - Predictions - Purchasable
CDC42_HUMAN
Orphanet
24399
HMDB Protein
HMDBP01784
Interactors (52)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.957
19
UniProt:P42768 WAS
2
WAS [cytosol]
(R-HSA-201879)
p-Y291-WAS [cytosol]
(R-HSA-2197668)
0.949
14
UniProt:Q13153 PAK1
5
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
Active PAK1 [cytosol]
(R-HSA-8964622)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.944
15
UniProt:Q9BYG5 PARD6B
2
PARD6B [plasma membrane]
(R-HSA-418193)
PARD6B [cytosol]
(R-HSA-419973)
0.896
18
UniProt:Q00587 CDC42EP1
1
CDC42EP1 [cytosol]
(R-HSA-9691382)
0.886
9
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
0.874
9
UniProt:O14613 CDC42EP2
2
p-CDC42EP2 [cytosol]
(R-HSA-5692662)
CDC42EP2 [cytosol]
(R-HSA-5692692)
0.83
10
UniProt:O96013 PAK4
1
PAK4 [cytosol]
(R-HSA-428461)
0.825
5
UniProt:Q5VT25 CDC42BPA
1
CDC42BPA [cytosol]
(R-HSA-419871)
0.815
6
GTP [ChEBI:15996]
7
GTP [cilium]
(R-ALL-5617813)
GTP [early endosome membrane]
(R-ALL-2130170)
GTP [lysosomal membrane]
(R-ALL-2213216)
GTP [platelet dense granule lumen]
(R-ALL-114625)
GTP [cytoplasmic vesicle membrane]
(R-ALL-1996291)
GTP [ER to Golgi transport vesicle membrane]
(R-ALL-983318)
GTP [Golgi membrane]
(R-ALL-1806221)
0.797
8
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.794
10
UniProt:P52565 ARHGDIA
1
ARHGDIA [cytosol]
(R-HSA-194478)
0.756
5
UniProt:Q9NPB6 PARD6A
4
PARD6A [plasma membrane]
(R-HSA-418187)
PARD6A [cytosol]
(R-HSA-420001)
PARD6A [cell junction]
(R-HSA-2134480)
p-S345-PARD6A [plasma membrane]
(R-HSA-2134533)
0.755
7
UniProt:O00401 WASL
4
N-WASP [cytosol]
(R-HSA-201873)
p-Y256-WASL [cytosol]
(R-HSA-2197672)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.75
4
UniProt:Q9P286 PAK5
2
PAK7 [plasma membrane]
(R-HSA-211555)
PAK5 [cytosol]
(R-HSA-428459)
0.743
5
UniProt:Q9JK83
2
Pard6b [plasma membrane]
(R-MMU-418193)
Pard6b [cytosol]
(R-MMU-419973)
0.729
6
UniProt:Q9NRR3 CDC42SE2
1
CDC42SE2 [plasma membrane]
(R-HSA-9714853)
0.725
5
UniProt:Q13576 IQGAP2
3
IQGAP2 [plasma membrane]
(R-HSA-6804811)
IQGAP2 [secretory granule membrane]
(R-HSA-6804779)
IQGAP2 [cytosol]
(R-HSA-5625975)
0.688
4
UniProt:Q9BYG4 PARD6G
2
PARD6G [plasma membrane]
(R-HSA-418192)
PARD6G [cytosol]
(R-HSA-419967)
0.681
5
UniProt:P19878 NCF2
2
p-T233-NCF2 [phagolysosome]
(R-HSA-1996211)
NCF2 [cytosol]
(R-HSA-1222600)
0.676
3
UniProt:P41743 PRKCI
3
PRKCI [nucleoplasm]
(R-HSA-9021345)
PRKCI [cytosol]
(R-HSA-58206)
PRKCI [plasma membrane]
(R-HSA-420005)
0.67
5
UniProt:P25054 APC
20
APC R213* [cytosol]
(R-HSA-9666924)
APC C1410* [cytosol]
(R-HSA-9666925)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
0.668
9
UniProt:Q9UQB8-4 BAIAP2
0.667
4
UniProt:Q9NRR8 C42S1
0.659
3
UniProt:Q9NQU5 PAK6
1
PAK6 [cytosol]
(R-HSA-428454)
0.659
4
UniProt:Q61036 Pak3
3
phospho-p-S154,T436-PAK3 [plasma membrane]
(R-MMU-3928479)
phospho-p-S154,T436-PAK3 [cytosol]
(R-MMU-5357471)
Pak3 [cytosol]
(R-MMU-442833)
0.656
3
UniProt:Q86VI3 IQGAP3
1
IQGAP3 [cytosol]
(R-HSA-5625977)
0.643
5
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.621
3
UniProt:Q92963 RIT1
1
RIT1 [plasma membrane]
(R-HSA-187703)
0.619
6
UniProt:Q15642 TRIP10
1
TRIP10 [cytosol]
(R-HSA-195120)
0.609
2
UniProt:O30916 SOPB
0.602
5
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.573
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.564
2
UniProt:O52623 SOPE
0.558
2
UniProt:Q8WUI4-6 HDAC7
0.556
3
UniProt:Q00587-2 CDC42EP1
0.556
3
UniProt:B2RTY4 MYO9A
1
MYO9A [cytosol]
(R-HSA-200628)
0.553
2
UniProt:Q9Y5S2 CDC42BPB
1
CDC42BPB [cytosol]
(R-HSA-419873)
0.547
2
UniProt:P52306 RAP1GDS1
1
RAP1GDS1 [mitochondrial outer membrane]
(R-HSA-9693756)
0.547
2
UniProt:P35268 RPL22
1
RPL22 [cytosol]
(R-HSA-72428)
0.547
2
UniProt:Q9H3Q1 CDC42EP4
1
CDC42EP4 [cytosol]
(R-HSA-9691381)
0.547
2
UniProt:Q16584 MAP3K11
1
MAP3K11 [cytosol]
(R-HSA-449607)
0.536
3
UniProt:Q9VEX9
1
Bin1 [nucleoplasm]
(R-DME-351694)
0.527
2
UniProt:P60660 MYL6
2
p-S20-MYL6 [cytosol]
(R-HSA-445778)
MYL6 [cytosol]
(R-HSA-419186)
0.527
2
UniProt:Q9UHB6 LIMA1
0.527
2
UniProt:O15511 ARPC5
4
ARPC5 [secretory granule lumen]
(R-HSA-6801071)
ARPC5 [extracellular region]
(R-HSA-6806476)
ARPC5 [ficolin-1-rich granule lumen]
(R-HSA-6801065)
ARPC5 [cytosol]
(R-HSA-200806)
0.527
2
UniProt:O08816 Wasl
1
N-Wasp [cytosol]
(R-RNO-442543)
0.524
2
UniProt:P60953 CDC42
3
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
0.524
2
UniProt:O95477 ABCA1
11
ABCA1 W590S [plasma membrane]
(R-HSA-5682201)
ABCA1 N935S [plasma membrane]
(R-HSA-5682200)
ABCA1 C1417R [plasma membrane]
(R-HSA-5682190)
ABCA1 S1446L [plasma membrane]
(R-HSA-5682195)
ABCA1 R587W [plasma membrane]
(R-HSA-5682197)
ABCA1 [plasma membrane]
(R-HSA-194209)
4xPALM-C-p-2S-ABCA1 [plasma membrane]
(R-HSA-5682069)
4xPALM-C-ABCA1 [endoplasmic reticulum membrane]
(R-HSA-5682085)
4xPALM-C-ABCA1 [plasma membrane]
(R-HSA-5682091)
ABCA1 [endoplasmic reticulum membrane]
(R-HSA-5682105)
ABCA1 Q537R [plasma membrane]
(R-HSA-5682199)
0.524
2
UniProt:Q96L34 MARK4
1
MARK4 [cytosol]
(R-HSA-5626653)
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
11
UniProt:P45983 MAPK8
3
MAPK8 [cytosol]
(R-HSA-168141)
p-T,Y-MAPK8 [cytosol]
(R-HSA-194371)
p-T,Y-MAPK8 [nucleoplasm]
(R-HSA-216349)
0.483
2
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