Reactome | Acetylation of glucosamine 6-phosphate to GlcNAc6P

Acetylation of glucosamine 6-phosphate to GlcNAc6P

Stable Identifier

R-HSA-449734

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)
        
        Acetylation of glucosamine 6-phosphate to GlcNAc6P (Homo sapiens)

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Acetylation of glucosamine 6-phosphate to GlcNAc6P

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Cytosolic GNPNAT1 catalyzes the reaction of glucosamine 6-phosphate and acetyl-CoA to form N-acetyl-glucosamine 6-phosphate (GlcNAc6P) and CoA-SH. Structural studies indicate that the active form of the enzyme is a dimer (Wang J et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
18675810	Acceptor substrate binding revealed by crystal structure of human glucosamine-6-phosphate N-acetyltransferase 1 Wang, J, Liang, YH, Liu, X, Su, XD, Li, LF	FEBS Lett	2008