pyrophosphate + H2O => 2 orthophosphate [mitochondrial]

Stable Identifier
R-HSA-449937
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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pyrophosphate + H2O => 2 orthophosphate [mitochondrial]
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Mitochondrial PPA2 (pyrophosphatase (inorganic) 2) catalyzes the hydrolysis of pyrophosphate to yield two molecules of orthophosphate. The enzyme requires Mg++ for activity (Curbo et al. 2006). The enzyme is inferred to be a homodimer by analogy to its cytosolic isoform.
Literature References
PubMed ID Title Journal Year
16300924 Human mitochondrial pyrophosphatase: cDNA cloning and analysis of the gene in patients with mtDNA depletion syndromes

Carrozzo, R, Palenzuela, L, Curbo, S, Hirano, M, Lucioli, S, Arenas, J, Karlsson, A, Santorelli, F, Johansson, M, Lagier-Tourenne, C

Genomics 2006
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as an event of
Catalyst Activity

inorganic diphosphatase activity of PPA2 dimer [mitochondrial matrix]

Physical Entity
PPA2 dimer [mitochondrial matrix] (Homo sapiens)
Activity
inorganic diphosphatase activity (GO:0004427)
This event is regulated
Requirements
Orthologous Events
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Bos taurus)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Caenorhabditis elegans)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Canis familiaris)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Danio rerio)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Dictyostelium discoideum)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Drosophila melanogaster)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Gallus gallus)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Mus musculus)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Plasmodium falciparum)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Rattus norvegicus)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Saccharomyces cerevisiae)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Schizosaccharomyces pombe)
pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Sus scrofa)
Cross References
Rhea
Authored
D'Eustachio, P  (2009-12-10)
Reviewed
Jassal, B  (2010-02-27)
Created
D'Eustachio, P  (2009-12-10)
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