Reactome | IL7:IL7R:JAK1 binds IL2RG:JAK3

IL7:IL7R:JAK1 binds IL2RG:JAK3

Stable Identifier

R-HSA-449958

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Studies using chemical crosslinking and monoclonal antibodies specific for Cytokine receptor common subunit gamma (IL2RG) demonstrated that it participates in the functional high-affinity interleukin-7 receptor complex (Noguchi et al. 1993, Kondo et al. 1994).
IL2RG interacts with the intermediate 1:1 IL7:IL7R complex, forming the active ternary complex, which binds Interleukin-7 (IL7) with a 3-fold higher affinity (Kd =80 pM).

Literature References

PubMed ID	Title	Journal	Year
8128231	Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes Takeshita, T, Higuchi, M, Sugamura, K, Sudo, T, Kondo, M, Nishikawa, S, Nakamura, M	Science	1994
8266077	Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor Tsang, M, Cao, X, Ziegler, SF, Russell, SM, Noguchi, M, Nakamura, Y, Leonard, WJ	Science	1993