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GLUT1 tetramer binds 4xATP
Stable Identifier
R-HSA-450088
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Cellular hexose transport (Homo sapiens)
GLUT1 tetramer binds 4xATP (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic ATP reversibly associates with GLUT1. This association inhibits GLUT1 glucose transport (Blodgett et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
17635959
Structural basis of GLUT1 inhibition by cytoplasmic ATP
Blodgett, DM
,
Levine, KB
,
Karim, P
,
De Zutter, JK
,
Carruthers, A
J Gen Physiol
2007
Participants
Input
x 4
ATP [cytosol]
GLUT1 / SLC2A1 tetramer [plasma membrane]
(Homo sapiens)
Output
GLUT1:ATP tetramer [plasma membrane]
(Homo sapiens)
Participates
as an event of
Cellular hexose transport (Homo sapiens)
Event Information
Go Biological Process
regulation of glucose transmembrane transport (0010827)
Reverse Reaction
GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Homo sapiens)
Orthologous Events
GLUT1 tetramer binds 4xATP (Bos taurus)
GLUT1 tetramer binds 4xATP (Caenorhabditis elegans)
GLUT1 tetramer binds 4xATP (Canis familiaris)
GLUT1 tetramer binds 4xATP (Danio rerio)
GLUT1 tetramer binds 4xATP (Dictyostelium discoideum)
GLUT1 tetramer binds 4xATP (Drosophila melanogaster)
GLUT1 tetramer binds 4xATP (Gallus gallus)
GLUT1 tetramer binds 4xATP (Mus musculus)
GLUT1 tetramer binds 4xATP (Plasmodium falciparum)
GLUT1 tetramer binds 4xATP (Rattus norvegicus)
GLUT1 tetramer binds 4xATP (Saccharomyces cerevisiae)
GLUT1 tetramer binds 4xATP (Sus scrofa)
GLUT1 tetramer binds 4xATP (Xenopus tropicalis)
Authored
D'Eustachio, P (2009-12-12)
Reviewed
Rush, MG (2024-03-06)
Graves, L (2024-03-06)
Created
D'Eustachio, P (2009-12-12)
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