Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-T221,Y223-MAPK10 [cytosol]
Stable Identifier
R-HSA-450214
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-T221,Y223-JNK3, MAPK10(phosphorylated)
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated human JNKs migrate to nucleoplasm (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)
p-MAPK8,9,10 [cytosol] (Homo sapiens)
p-T221,Y223-MAPK10 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P53779 MAPK10
Gene Names
MAPK10, JNK3, JNK3A, PRKM10, SAPK1B
Chain
chain:1-464
Reference Genes
BioGPS Gene:5602 MAPK10
COSMIC (genes):MAPK10 MAPK10
CTD Gene:5602 MAPK10
dbSNP Gene:5602 MAPK10
ENSEMBL:ENSG00000109339 MAPK10
ENSEMBL_homo_sapiens_GENE:ENSG00000109339.24 MAPK10
HGNC:6872 MAPK10
KEGG Gene (Homo sapiens):5602 MAPK10
Monarch:5602 MAPK10
NCBI Gene:5602 MAPK10
OMIM:602897 MAPK10
UCSC:P53779 MAPK10
Reference Transcript
RefSeq:XM_017008424.1 MAPK10
RefSeq:XM_017008425.1 MAPK10
RefSeq:XM_005263135.3 MAPK10
RefSeq:XM_006714268.2 MAPK10
RefSeq:NM_138982.3 MAPK10
RefSeq:XM_017008419.1 MAPK10
RefSeq:XM_017008420.1 MAPK10
RefSeq:XM_005263129.2 MAPK10
RefSeq:XM_017008421.1 MAPK10
RefSeq:XM_017008423.1 MAPK10
RefSeq:XM_005263130.2 MAPK10
RefSeq:XM_011532120.2 MAPK10
RefSeq:NM_002753.4 MAPK10
RefSeq:XM_017008431.1 MAPK10
RefSeq:XM_011532121.2 MAPK10
RefSeq:XM_017008432.1 MAPK10
RefSeq:NM_138980.3 MAPK10
RefSeq:XM_017008426.1 MAPK10
RefSeq:NM_001318067.1 MAPK10
RefSeq:XM_017008429.1 MAPK10
RefSeq:XM_011532117.2 MAPK10
RefSeq:NM_001318068.1 MAPK10
RefSeq:XM_011532118.2 MAPK10
RefSeq:NM_001318069.1 MAPK10
RefSeq:XM_017008430.1 MAPK10
Other Identifiers
214376_PM_at
214376_at
237413_PM_at
237413_at
2776659
2776661
2776663
2776665
2776667
2776669
2776671
2776756
2776757
2776758
2776759
2776760
2776761
2776762
2776763
2776765
2776767
2776773
2776795
2776796
2776797
2776798
2776799
2776800
2776801
2776802
2776803
37852_at
45430_at
5602
A_24_P810104
A_33_P3254216
GE54461
GE62730
GO:0000165
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004705
GO:0004707
GO:0004708
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006468
GO:0007165
GO:0007254
GO:0009416
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0033554
GO:0036211
GO:0038095
GO:0042752
GO:0043226
GO:0048511
GO:0090398
GO:0106310
GO:0140096
HMNXSV003004267
HMNXSV003054415
Hs.13438.0.S1_3p_at
Hs.25209.0.A1_3p_at
ILMN_1659513
ILMN_1748281
ILMN_1766904
ILMN_1858387
ILMN_2256907
ILMN_2340131
PH_hs_0001294
PH_hs_0031094
TC04002620.hg
p12364
Participates
as a member of
p-MAPK8,9,10 [cytosol] (Homo sapiens)
Other forms of this molecule
MAPK10 [cytosol]
p-T221,Y223-MAPK10 [nucleoplasm]
Inferred To
phospho-kgb-2 [cytosol]
(Caenorhabditis elegans)
phospho-p-T221,Y223-MAPK10 [cytosol]
(Caenorhabditis elegans)
phospho-p-T221,Y223-MAPK10 [cytosol]
(Dictyostelium discoideum)
phospho-p-T221,Y223-MAPK10 [cytosol]
(Drosophila melanogaster)
phospho-p-T221,Y223-MAPK10 [cytosol]
(Gallus gallus)
phospho-p-T221,Y223-MAPK10 [cytosol]
(Mus musculus)
phospho-p-T221,Y223-MAPK10 [cytosol]
(Rattus norvegicus)
phospho-p-T221,Y223-MAPK10 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-T221,Y223-MAPK10 [cytosol]
(Schizosaccharomyces pombe)
phospho-MAPK10 [cytosol]
(Bos taurus)
phospho-MAPK10 [cytosol]
(Canis familiaris)
phospho-MAPK10 [cytosol]
(Sus scrofa)
Homologues of p-T221,Y223-MAPK10 [cytosol]
(Caenorhabditis elegans)
Homologues of p-T221,Y223-MAPK10 [cytosol]
(Dictyostelium discoideum)
Modified Residues
Name
O-phospho-L-threonine at 221
Coordinate
221
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 223
Coordinate
223
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_011530423.1
,
XP_016863914.1
,
XP_011530422.1
,
XP_016863913.1
,
XP_016863918.1
,
XP_005263187.1
,
NP_001304996.1
,
NP_001304997.1
,
XP_016863912.1
,
XP_016863910.1
,
XP_005263186.1
,
XP_016863919.1
,
NP_001304998.1
,
XP_006714331.1
,
NP_620448.1
,
XP_011530419.1
,
XP_005263192.1
,
NP_620446.1
,
NP_002744.1
,
XP_016863920.1
,
XP_011530420.1
,
XP_016863909.1
,
XP_016863915.1
,
XP_016863908.1
,
XP_016863921.1
ZINC - World Drugs
MK10_HUMAN
Guide to Pharmacology - Targets
1498
OpenTargets
ENSG00000109339
ZINC - FDA approved
MK10_HUMAN
ZINC - Substances
MK10_HUMAN
ZINC target
P53779
ZINC - Biogenic
MK10_HUMAN
PRO
P53779
PDB
7ORF
,
7KSI
,
4KKE
,
7KSJ
,
2B1P
,
3OY1
,
2EXC
,
7YL1
,
4Y5H
,
4H39
,
7S1N
,
3OXI
,
2WAJ
,
7KSK
,
4H36
,
3G90
,
2OK1
,
4W4V
,
3G9N
,
8BZP
,
3FI3
,
3G9L
,
7ORE
,
3V6R
,
3V6S
,
4KKH
,
6EKD
,
2O2U
,
8ENJ
,
4KKG
,
3PTG
,
4W4X
,
4Y46
,
4Z9L
,
4WHZ
,
4W4W
,
1PMN
,
2R9S
,
4X21
,
3FV8
,
3KVX
,
4U79
,
2ZDU
,
2ZDT
,
6EMH
,
3CGO
,
3TTI
,
3TTJ
,
1PMU
,
3DA6
,
1JNK
,
8WGF
,
1PMV
,
4H3B
,
3RTP
,
2P33
,
3FI2
,
2O0U
,
4W4Y
,
3CGF
,
6EQ9
ZINC - Investigational
MK10_HUMAN
IntEnz
2.7.11.24
HPA
ENSG00000109339-MAPK10
GeneCards
P53779
Ensembl
ENSP00000493100
,
ENST00000641737
,
ENST00000641657
,
ENSP00000492941
,
ENSP00000493049
,
ENSP00000493444
,
ENSP00000492929
,
ENSP00000492292
,
ENSP00000378586
,
ENST00000641724
,
ENST00000515650
,
ENST00000641207
,
ENSP00000492942
,
ENST00000642009
,
ENST00000641050
,
ENSP00000491122
,
ENST00000642103
,
ENSP00000493435
,
ENST00000641170
,
ENST00000638313
,
ENST00000641283
,
ENST00000641287
,
ENST00000641823
,
ENST00000641110
,
ENSP00000493450
,
ENSP00000493177
,
ENST00000641952
,
ENST00000640858
,
ENSP00000493374
,
ENSP00000493290
,
ENST00000641862
,
ENST00000641983
,
ENSP00000493270
,
ENSP00000492231
,
ENSP00000493168
,
ENSP00000493396
,
ENSP00000493045
,
ENSP00000491866
,
ENST00000639175
,
ENSP00000493038
,
ENSP00000491089
,
ENSP00000492903
,
ENST00000639234
,
ENSP00000491306
,
ENSP00000493208
,
ENST00000639242
,
ENSP00000491160
,
ENSP00000493008
,
ENSP00000493408
,
ENSP00000492204
,
ENST00000395166
,
ENST00000641297
,
ENST00000641647
,
ENST00000395157
,
ENSP00000493105
,
ENSP00000378595
,
ENST00000641051
,
ENST00000641803
,
ENST00000641410
,
ENSP00000493237
,
ENSP00000493040
,
ENSP00000493363
,
ENST00000515400
,
ENST00000642015
,
ENSP00000493013
,
ENST00000641943
,
ENST00000638225
,
ENST00000641911
,
ENST00000641902
,
ENST00000641274
,
ENST00000641157
,
ENSG00000109339
,
ENST00000641391
,
ENSP00000493375
,
ENSP00000493092
,
ENST00000641462
,
ENST00000641341
,
ENST00000642038
,
ENST00000641066
,
ENSP00000493072
,
ENSP00000424154
,
ENSP00000493275
,
ENSP00000493163
,
ENST00000640970
,
ENSP00000493001
Pharos - Targets
P53779
ZINC - Predictions - Purchasable
MK10_HUMAN
Orphanet
19563
HMDB Protein
HMDBP01533
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.755
4
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.609
2
UniProt:P26038 MSN
4
MSN [cytosol]
(R-HSA-437350)
MSN(2-448)-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711966)
MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711971)
p-T558-MSN [cytosol]
(R-HSA-9663005)
0.527
2
UniProt:P15311 EZR
3
p-Y146,Y354-EZR [cytosol]
(R-HSA-374572)
p-T567-EZR [cytosol]
(R-HSA-374559)
EZR [cytosol]
(R-HSA-9020826)
0.527
2
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.508
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text