Reactome | FOS [nucleoplasm]

FOS [nucleoplasm]

Stable Identifier

R-HSA-450216

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

c-FOS

Locations in the PathwayBrowser for interactor IntAct:EBI-25856799 CCSB

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by NPAS4 (Homo sapiens)
      - NPAS4 regulates expression of target genes (Homo sapiens)
        
        NPAS4 stimulates FOS gene expression (Homo sapiens)
        
        FOS [nucleoplasm] (Homo sapiens)

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        c-FOS activation by phospho ERK1/2 (Homo sapiens)
        
        FOS [nucleoplasm] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated MAPK activation (Homo sapiens)
      - c-FOS activation by phospho ERK1/2 (Homo sapiens)
        
        FOS [nucleoplasm] (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        c-FOS activation by phospho ERK1/2 (Homo sapiens)
        
        FOS [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        c-FOS activation by phospho ERK1/2 (Homo sapiens)
        
        FOS [nucleoplasm] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        c-FOS activation by phospho ERK1/2 (Homo sapiens)
        
        FOS [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        c-FOS activation by phospho ERK1/2 (Homo sapiens)
        
        FOS [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        c-FOS activation by phospho ERK1/2 (Homo sapiens)
        
        FOS [nucleoplasm] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        c-FOS activation by phospho ERK1/2 (Homo sapiens)
        
        FOS [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        c-FOS activation by phospho ERK1/2 (Homo sapiens)
        
        FOS [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        c-FOS activation by phospho ERK1/2 (Homo sapiens)
        
        FOS [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        c-FOS activation by phospho ERK1/2 (Homo sapiens)
        
        FOS [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Nuclear Receptors (Homo sapiens)
  - ESR-mediated signaling (Homo sapiens)
    - Extra-nuclear estrogen signaling (Homo sapiens)
      - Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Homo sapiens)
        
        E2-mediated FOS gene expression (Homo sapiens)
        
        FOS [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01100 FOS

Gene Names

FOS, c-fos, G0S7

Chain

chain:1-380

Reference Genes

BioGPS Gene:2353 FOS

COSMIC (genes):FOS FOS

CTD Gene:2353 FOS

dbSNP Gene:2353 FOS

ENSEMBL:ENSG00000170345 FOS

HGNC:3796 FOS

KEGG:hsa:2353 FOS

Monarch:2353 FOS

NCBI Gene:2353 FOS

OMIM:164810 FOS

UCSC:P01100 FOS

Reference Transcript

RefSeq:NM_005252.3 FOS

Other Identifiers

11734658_s_at

11734659_a_at

11749291_a_at

11749852_s_at

16786587

1915_s_at

1916_s_at

209189_PM_at

209189_at

2094_s_at

2353

3544526

3544527

3544528

3544530

3544531

3544532

3544533

3544534

3544535

3544536

3544537

3544538

3544540

7975779

A_14_P107571

A_14_P117160

A_23_P106194

GE79024

GO:0000785

GO:0000976

GO:0000978

GO:0000979

GO:0000981

GO:0001221

GO:0001228

GO:0001661

GO:0003407

GO:0003677

GO:0003682

GO:0003690

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005783

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006954

GO:0007179

GO:0007399

GO:0007565

GO:0009410

GO:0009416

GO:0009612

GO:0009629

GO:0009636

GO:0010468

GO:0014070

GO:0014823

GO:0014856

GO:0016363

GO:0021987

GO:0022414

GO:0030154

GO:0030182

GO:0030316

GO:0032496

GO:0032570

GO:0032868

GO:0032870

GO:0032993

GO:0034097

GO:0034224

GO:0034614

GO:0035902

GO:0035914

GO:0035976

GO:0035994

GO:0042802

GO:0043226

GO:0043565

GO:0044877

GO:0045471

GO:0045672

GO:0045893

GO:0045944

GO:0048545

GO:0048856

GO:0050877

GO:0051412

GO:0051450

GO:0051591

GO:0060395

GO:0061629

GO:0070412

GO:0071276

GO:0071277

GO:0071356

GO:0071364

GO:0071374

GO:0071456

GO:0071560

GO:0072375

GO:0090575

GO:0140110

GO:0140467

GO:1902895

GO:1903131

GO:1904628

GO:1990646

GO:1990837

GO:1990841

HMNXSV003008025

ILMN_1669523

PH_hs_0002259

TC14000471.hg

V01512_rna1_at

g13325363_3p_at

Participates

as a member of

as an output of

as an input of

c-FOS activation by phospho ERK1/2 (Homo sapiens)

as a component of

FOS:JUN [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-T325,T331,S362,S374-FOS [nucleoplasm]

Inferred To

FOS [nucleoplasm] (Bos taurus)

FOS [nucleoplasm] (Canis familiaris)

FOS [nucleoplasm] (Gallus gallus)

FOS [nucleoplasm] (Sus scrofa)

fosab [nucleoplasm] (Danio rerio)

Fos [nucleoplasm] (Mus musculus)

Fos [nucleoplasm] (Rattus norvegicus)

fos [nucleoplasm] (Xenopus tropicalis)

kay [nucleoplasm] (Drosophila melanogaster)

fos-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_005243.1

OpenTargets

ENSG00000170345

ENSEMBL

ENSP00000452590, ENST00000555686, ENST00000535987, ENST00000303562, ENSP00000442268, ENSP00000306245

HPA

ENSG00000170345-FOS

PRO

P01100

Pharos - Targets

P01100

GlyGen

P01100

Orphanet

FOS

HMDB Protein

HMDBP14541

PDB

1FOS, 1S9K, 1A02

Interactors (73)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.975	44
UniProt:P17275 JUNB	1	JUNB [nucleoplasm] (R-HSA-2186795)	0.94	14
UniProt:P15336 ATF2	2	p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243) ATF2 [nucleoplasm] (R-HSA-450336)	0.937	15
UniProt:P17535 JUND	1	JUND [nucleoplasm] (R-HSA-9009924)	0.928	14
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.878	11
UniProt:Q8NHY2 RFWD2	3	p-S387-RFWD2 [cytosol] (R-HSA-349439) RFWD2 [nucleoplasm] (R-HSA-349454) p-S387-RFWD2 [nucleoplasm] (R-HSA-349450)	0.725	6
UniProt:Q8N2I9 STK40			0.725	4
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.706	4
UniProt:P17544 ATF7			0.688	5
UniProt:P26640 VARS1	1	VARS [cytosol] (R-HSA-379648)	0.643	3
UniProt:Q9Y5Q3 MAFB	1	MAFB [nucleoplasm] (R-HSA-3788667)	0.623	2
UniProt:Q96CM3 RUSD4			0.61	4
UniProt:P53567 CEBPG	1	CEBPG [nucleoplasm] (R-HSA-9644320)	0.592	2
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.59	2
UniProt:O14974 PPP1R12A	4	PPP1R12A [cytosol] (R-HSA-419070) p-T696-PPP1R12A [cytosol] (R-HSA-5668956) p-T696,S852-PPP1R12A [cytosol] (R-HSA-419079) p-S473-PPP1R12A [nucleoplasm] (R-HSA-3002801)	0.564	2
IntAct:EBI-25856799 CCSB			0.556	3
UniProt:P42336 PIK3CA	20	PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA [cytosol] (R-HSA-74787) PIK3CA R38C [cytosol] (R-HSA-1500691) PIK3CA R38G [cytosol] (R-HSA-2395950) PIK3CA R38S [cytosol] (R-HSA-2395947) PIK3CA R38H [cytosol] (R-HSA-1500718) PIK3CA E542Q [cytosol] (R-HSA-2328003) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA Q546K [cytosol] (R-HSA-1500705)	0.556	3
UniProt:Q9BWF3-2 RBM4			0.556	3
UniProt:Q9HC44 GPBL1			0.556	3
UniProt:CCDC26 A0A024R9H7			0.556	3
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
UniProt:Q9H0I2 ENKD1			0.556	3
UniProt:Q02930-3 CREB5			0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q13829 TNFAIP1	1	TNFAIP1 [cytosol] (R-HSA-9696531)	0.556	3
UniProt:Q9P1W8 SIRPG	1	SIRPG [plasma membrane] (R-HSA-197571)	0.556	3
UniProt:Q9BZM4 ULBP3	1	ULBP3 [plasma membrane] (R-HSA-198076)	0.556	3
UniProt:Q14994 NR1I3			0.556	3
UniProt:Q9UNY5 ZN232			0.556	3
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.556	3
UniProt:Q13352 ITGB3BP	2	ITGB3BP [nucleoplasm] (R-HSA-606325) ITGB3BP [cytosol] (R-HSA-3006405)	0.556	3
UniProt:O60880 SH2D1A	1	SH2D1A [cytosol] (R-HSA-5685108)	0.556	3
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.556	3
UniProt:P52566 ARHGDIB	1	ARHGDIB [cytosol] (R-HSA-195081)	0.556	3
UniProt:Q15907 RAB11B	3	RAB11B [recycling endosome membrane] (R-HSA-8854762) GGC-RAB11B [cytosol] (R-HSA-8873766) RAB11B [cytosol] (R-HSA-8873671)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.556	3
UniProt:Q9UFG5 CS025			0.556	3
UniProt:Q9BRT8 ZNG1A			0.556	3
UniProt:Q6ZMY6-2 Q6ZMY62			0.556	3
UniProt:P25372	2	TRX3 [cytosol] (R-SCE-73668-3) TRX3 [cytosol] (R-SCE-66000-3)	0.556	3
UniProt:Q9UI10 EIF2B4	1	EIF2B4 [cytosol] (R-HSA-72521)	0.556	3
UniProt:Q6XD76 ASCL4			0.556	3
UniProt:P11684 UTER			0.556	3
UniProt:Q13322-4 GRB10			0.556	3
UniProt:Q9NQC1-2 JADE2			0.556	3
UniProt:Q96HB5 CC120			0.556	3
UniProt:O14796 SH2D1B	1	SH2D1B [cytosol] (R-HSA-5685187)	0.556	3
UniProt:Q96A09 TET5B			0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
UniProt:Q9Y6G5 COMMD10	2	COMMD10 [nucleoplasm] (R-HSA-8955101) COMMD10 [cytosol] (R-HSA-8955105)	0.556	3
UniProt:Q14693 LPIN1	3	LPIN1 [endoplasmic reticulum membrane] (R-HSA-549157) LPIN1 [nuclear envelope] (R-HSA-4419927) p-S106-LPIN1 [nucleoplasm] (R-HSA-4419936)	0.556	3
UniProt:Q8NFB2 T185A			0.556	3
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.536	6
UniProt:Q96L91 EP400	1	EP400 [nucleoplasm] (R-HSA-3321987)	0.536	2
UniProt:Q7L5Y6 DET1	1	DET1 [cytosol] (R-HSA-976007)	0.527	2
UniProt:Q96RU8 TRIB1	1	TRIB1 [cytosol] (R-HSA-9621338)	0.527	2
UniProt:O95619 YEATS4	1	YEATS4 [nucleoplasm] (R-HSA-3322940)	0.527	2
UniProt:P56671 MAZ			0.525	2
UniProt:P52736 ZNF133	1	ZNF133 [nucleoplasm] (R-HSA-975036)	0.524	4
UniProt:P10909 CLU	4	CLU(23-449) [extracellular region] (R-HSA-349732) CLU(23-449) [platelet alpha granule lumen] (R-HSA-349733) CLU(228-449) [extracellular region] (R-HSA-6810626) CLU(23-227) [extracellular region] (R-HSA-6810660)	0.524	2
UniProt:P56279 TCL1A			0.524	4
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.524	3
UniProt:Q9BT78 COPS4	2	COPS4 [nucleoplasm] (R-HSA-5697020) COPS4 [cytosol] (R-HSA-416965)	0.524	2
IntAct:EBI-10042615 VGF			0.499	2
UniProt:Q03112 MECOM	2	MECOM [cytosol] (R-HSA-5634790) MECOM [nucleoplasm] (R-HSA-8943897)	0.499	4
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.483	2
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.483	2
UniProt:Q8TAQ2 SMARCC2	1	SMARCC2 [nucleoplasm] (R-HSA-389263)	0.483	2
UniProt:Q12857 NFIA	1	NFIA [nucleoplasm] (R-HSA-60134)	0.471	2
IntAct:EBI-10041770 MMP1			0.462	4
IntAct:EBI-10041773 MMP1			0.462	3
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.462	3

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