Reactome | p-S207,T211-MAP2K6 [nucleoplasm]

p-S207,T211-MAP2K6 [nucleoplasm]

Stable Identifier

R-HSA-450258

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-S207,T211-MKK6, mitogen-activated protein kinase kinase 6 (phosphorylated)

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Locations in the PathwayBrowser for interactor UniProt:Q9Y6R4 M3K4

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        PI5P Regulates TP53 Acetylation (Homo sapiens)
        
        MAP2K6 phosphorylates PIP4K2B (Homo sapiens)
        
        p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P52564 MAP2K6

Gene Names

MAP2K6, MEK6, MKK6, PRKMK6, SKK3

Chain

chain:1-334

Reference Genes

COSMIC (genes):MAP2K6 MAP2K6

dbSNP Gene:5608 MAP2K6

ENSEMBL:ENSG00000108984 MAP2K6

Participates

as a member of

p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

MAP2K6 [cytosol]

p-S207,T211-MAP2K6 [cytosol]

Inferred To

phospho-lic [nucleoplasm] (Drosophila melanogaster)

phospho-sek-5 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S207,T211-MAP2K6 [nucleoplasm] (Bos taurus)

phospho-p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S207,T211-MAP2K6 [nucleoplasm] (Danio rerio)

phospho-p-S207,T211-MAP2K6 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-S207,T211-MAP2K6 [nucleoplasm] (Gallus gallus)

phospho-p-S207,T211-MAP2K6 [nucleoplasm] (Mus musculus)

phospho-p-S207,T211-MAP2K6 [nucleoplasm] (Rattus norvegicus)

phospho-p-S207,T211-MAP2K6 [nucleoplasm] (Sus scrofa)

phospho-p-S207,T211-MAP2K6 [nucleoplasm] (Xenopus tropicalis)

Homologues of p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)

phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)

phospho-MAP2K6 [nucleoplasm] (Canis familiaris)

Modified Residues

Name

O-phospho-L-serine at 207

Coordinate

207

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 211

Coordinate

211

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.625	5
UniProt:P46734 MAP2K3	3	MAP2K3 [cytosol] (R-HSA-168051) p-S218,T222-MAP2K3 [cytosol] (R-HSA-167955) p-S218,T222-MAP2K3 [nucleoplasm] (R-HSA-450229)	0.615	3
UniProt:Q16539 MAPK14	7	MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.564	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P24522 GADD45A	1	GADD45A [nucleoplasm] (R-HSA-3215139)	0.519	2
UniProt:Q9Y6R4 M3K4			0.519	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.463	4

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