Reactome | TAB2 [endosome membrane]

TAB2 [endosome membrane]

Stable Identifier

R-HSA-450279

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Mitogen-activated protein kinase kinase kinase 7 interacting protein 2

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External Reference Information

External Reference

UniProt:Q9NYJ8 TAB2

Gene Names

TAB2, KIAA0733, MAP3K7IP2

Chain

chain:1-693

Reference Genes

BioGPS Gene:23118 TAB2

COSMIC (genes):TAB2 TAB2

CTD Gene:23118 TAB2

dbSNP Gene:23118 TAB2

ENSEMBL:ENSG00000055208 TAB2

ENSEMBL_homo_sapiens_GENE:ENSG00000055208.20 TAB2

HGNC:17075 TAB2

KEGG Gene (Homo sapiens):23118 TAB2

Monarch:23118 TAB2

NCBI Gene:23118 TAB2

OMIM:605101 TAB2

UCSC:Q9NYJ8 TAB2

Reference Transcript

Other Identifiers

11743012_at

11750741_a_at

11754101_x_at

11757315_s_at

17013567

210284_PM_s_at

210284_s_at

212184_PM_s_at

212184_s_at

23118

2930603

2930606

2930616

2930623

2930624

2930627

2930628

2930629

2930633

2930635

2930636

2930637

2930642

2930643

2930644

2930645

2930646

2930647

2930648

2930649

2930650

2930651

2930652

2930706

38980_at

8122672

A_14_P121269

A_14_P135290

A_23_P19702

A_33_P3404331

GE56455

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005829

GO:0005886

GO:0006914

GO:0006954

GO:0007507

GO:0008270

GO:0010008

GO:0010507

GO:0016020

GO:0023052

GO:0031410

GO:0032496

GO:0036211

GO:0038061

GO:0042742

GO:0043123

GO:0043130

GO:0043226

GO:0045860

GO:0046872

GO:0048856

GO:0060090

GO:0070530

GO:0098542

HMNXSV003018647

Hs.109727.1.S1_3p_a_at

ILMN_1672331

ILMN_1808322

PH_hs_0006053

PH_hs_0040402

g7677465_3p_a_at

Participates

as a member of

TAB2/3 [endosome membrane] (Homo sapiens)

Other forms of this molecule

TAB2 [cytosol]

TAB2 [plasma membrane]

TAB2 [nucleoplasm]

Inferred To

Tab2 [endosome membrane] (Mus musculus)

Tab2 [endosome membrane] (Rattus norvegicus)

tab2 [endosome membrane] (Xenopus tropicalis)

TAB2 [endosome membrane] (Bos taurus)

TAB2 [endosome membrane] (Canis familiaris)

TAB2 [endosome membrane] (Gallus gallus)

TAB2 [endosome membrane] (Sus scrofa)

Cross References

RefSeq

NP_001278963.1, XP_016866081.1, XP_011533935.1, NP_001278964.1, XP_016866080.1, NP_055908.1

OpenTargets

ENSG00000055208

GeneCards

Q9NYJ8

HPA

ENSG00000055208-TAB2

Ensembl

ENST00000367456, ENSP00000356426, ENSP00000432709, ENSG00000055208, ENST00000470466, ENSP00000490618, ENST00000637181

PRO

Q9NYJ8

Pharos - Targets

Q9NYJ8

Orphanet

24961

PDB

2DAE, 2WX1, 2WWZ, 2WX0

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) p-MAP3K7 [cytosol] (R-HSA-168163) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.91	8
UniProt:Q15750 TAB1	6	TAB1(445-504) [cytosol] (R-HSA-9729691) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1 [endosome membrane] (R-HSA-450238) TAB1 [cytosol] (R-HSA-167923)	0.902	9
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.678	3
UniProt:Q14457 BECN1	4	K63polyUb-BECN1 [cytosol] (R-HSA-6782989) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) p-S15-BECN1 [cytosol] (R-HSA-5682391) BECN1 [cytosol] (R-HSA-1632841)	0.655	11
UniProt:Q62073 Map3k7	10	Phospho TAK1 [cytosol] (R-MMU-205840) PolyUb-MAP3K7 [cytosol] (R-MMU-6782968) phospho-K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-MMU-5607649) K63polyUb-34,158-TAK1 [cytosol] (R-MMU-5607643) phospho-p-MAP3K7 [cytosol] (R-MMU-168163) phospho-p-T187-MAP3K7 [cytosol] (R-MMU-206014) MAP3K7 [endosome membrane] (R-MMU-450315) phospho-p-T184,T187-MAP3K7 [endosome membrane] (R-MMU-450332) MAP3K7 [cytosol] (R-MMU-168156) phospho-p-T184,T187-MAP3K7 [cytosol] (R-MMU-202527)	0.59	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.564	2
UniProt:P52747 ZNF143	1	ZNF143 [nucleoplasm] (R-HSA-83837)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.536	2
UniProt:Q9Y2G2 CARD8	1	CARD8 [cytosol] (R-HSA-6805447)	0.527	2
UniProt:Q8N4J0 CARNMT1	1	CARNMT1 [cytosol] (R-HSA-8876689)	0.527	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.488	2

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