Reactome | Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.

Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.

Stable Identifier

R-HSA-450292

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated MAPK activation (Homo sapiens)
      - Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. (Homo sapiens)

General

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Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.

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The bZIP domains of Jun and Fos form an X-shaped -helical structure, which binds to the palindromic AP-1 site (TGAGTCA) (Glover and Harrison, 1995).

Literature References

PubMed ID	Title	Journal	Year
7816143	Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA Glover, JN, Harrison, SC	Nature	1995
9030721	Regulatory mechanisms involved in activator-protein-1 (AP-1)-mediated activation of glutathione-S-transferase gene expression by chemical agents Daniel, V, Pinkus, R, Bergelson, S, Ainbinder, E	Eur J Biochem	1997